Patent US4851224A successfully refreshed from Google Patents.
US4851224A
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Process for preparation of aloe products
Assignee: Carrington Laboratories Inc
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Filing: 1988-01-14
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Granted: 1989-07-25
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Expires: 2008-01-14
Abstract
Abstract A process is described for extracting a pharmaceutically active polysaccharidic substance from the aloe plant. The pharmaceutically active polysaccharidic substance and its characteristic properties are described.
Inventors
- 👤 Bill H. McAnalley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:07
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0003; A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K36/00; A61K36/18; A61K36/88; A61K36/886; A61K8/00; A61K8/18; A61K8/96; A61K8/97; A61K8/9783; A61K8/9794; A61K9/00; A61K9/0012; A61K9/0014; A61K9/14; A61K9/19; A61P; A61P1/00; A61P1/04; A61P1/10; A61P31/00; A61P31/04; A61P37/00; A61P37/08; A61P43/00; A61P7/00; A61P7/04; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/244; A61K2236/00; A61K2236/30; A61Q; A61Q17/00; A61Q17/04; Y; Y10; Y10S; Y10S424/00; Y10S424/13
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
103 words
A process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, comprising the steps of: (a) obtaining aloe juice having solubilized matter; (b) adjusting the pH of said aloe juice of from about 3.00 to about 3.50; (c) adding a water soluble, lower aliphatic polar solvent to the aloe juice to precipitate the active chemical substance and thereby to form a heterogeneous solution; (d) removing the water soluble, lower aliphatic polar solvent and the solubilized matter from the heterogeneous solution to isolate the precipitated active chemical substance; and (e) drying the precipitated active chemical substance.
Claim 2
Dependent Claim
103 words
A process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, comprising the steps of: (a) obtaining aloe juice having solubilized matter; (b) adjusting the pH of said aloe juice of from about 3.00 to about 3.50; (c) adding a water soluble, lower aliphatic polar solvent to the aloe juice to precipitate the active chemical substance and thereby to form a heterogeneous solution; (d) removing the water soluble, lower aliphatic polar solvent and the solubilized matter from the heterogeneous solution to isolate the precipitated active chemical substance; and (e) drying the precipitated active chemical substance.
Claim 3
Dependent Claim
106 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant according to claim 1, wherein said aloe juice is obtained by: (a) washing an aloe leaf in a bacteriacidal solution to remove substantially all surface dirt and bacteria; (b) removing at least a first end portion from said washed leaf; (c) draining, preserving and collecting anthraquinone rich sap from said cut and washed leaf; (d) removing rind from said leaf to produce a substantially anthraquinone-free gel fillet; and (e) grinding and homogenizing said substantially anthraquinone-free aloe gel fillet to produce substantially anthraquinone-free aloe juice having solubilized matter.
Claim 4
Dependent Claim
75 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said aloe juice is obtained by: (a) washing an aloe leaf in a bacteriacidal solution to remove substantially all surface dirt and bacteria; (b) crushing the washed aloe leaf; and (c) dialyzing the crushed leaf chemically to remove and separate a substantially anthraquinone-free gel from remaining fractions of the crushed leaf.
Claim 5
Dependent Claim
69 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said aloe juice is obtained by: (a) washing an aloe leaf in a bacteriacidal solution to remove substantially all surface dirt and bacteria; (b) crushing the washed aloe leaf; and (c) grinding and homogenizing said crushed aloe leaf to produce aloe juice having solubilized matter.
Claim 6
Dependent Claim
78 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said aloe juice is obtained by: (a) washing an aloe leaf in a bacteriacidal solution substantially to remove surface dirt and bacteria; (b) grinding said washed aloe leaf; (c) filtering said ground aloe leaf to remove fibrous material; and (d) homogenizing said ground aloe leaf to produce an anthraquinone-rich aloe juice having solubilized matter.
Claim 7
Dependent Claim
45 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said aloe juice is obtained by: (a) crushing a leaf of an aloe plant to extrude aloe juice having solubilized matter.
Claim 8
Dependent Claim
75 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said aloe juice is obtained by: (a) washing an aloe leaf in a bacteriacidal solution to remove substantially all surface dirt and bacteria; (b) removing rind from said leaf to produce an aloe gel fillet; and (c) grinding and homogenizing said aloe gel fillet to produce aloe juice having solubilized matter.
Claim 9
Dependent Claim
37 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said precipitate is irradiated, whereby said active chemical substance is sterilized and preserved.
Claim 10
Dependent Claim
48 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein four volumes of said water soluble, lower aliphatic polar solvent are added to one volume of aloe juice to precipitate said active chemical substance.
Claim 11
Dependent Claim
42 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said water soluble, lower aliphatic polar solvent is selected from the group consisting of methanol, ethanol and propanol.
Claim 12
Dependent Claim
33 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 10, wherein said water soluble, lower aliphatic polar solvent is ethanol.
Claim 13
Dependent Claim
55 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said active chemical substance is precipitated from said water soluble, lower aliphatic polar solvent and aloe juice for approximately four hours before said water soluble, lower aliphatic polar solvent is removed.
Claim 14
Dependent Claim
33 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, wherein said precipitated active chemical substance is dried by lyophilization.
Claim 15
Dependent Claim
59 words
The process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, according to claim 1, further comprising the steps of: (f) redissolving the precipitated active chemical substance in phosphate buffer; (g) treating the redissolved precipated active chemical substance with non-specific protease followed by extensive dialysis; and (h) lyophilizing the non-filterable product.
Claim 16
Dependent Claim
9 words
A product produced by the process of claim 1.
Claim 17
Dependent Claim
9 words
A product produced by the process of claim 2.
Claim 18
Dependent Claim
9 words
A product produced by the process of claim 3.
Claim 19
Dependent Claim
9 words
A product produced by the process of claim 4.
Claim 20
Dependent Claim
9 words
A product produced by the process of claim 5.
Claim 21
Dependent Claim
9 words
A product produced by the process of claim 6.
Claim 22
Dependent Claim
9 words
A product produced by the process of claim 7.
Claim 23
Dependent Claim
9 words
A product produced by the process of claim 8.
Claim 24
Dependent Claim
9 words
A product produced by the process of claim 9.
Claim 25
Dependent Claim
9 words
A product produced by the process of claim 10.
Claim 26
Dependent Claim
9 words
A product produced by the process of claim 11.
Claim 27
Dependent Claim
9 words
A product produced by the process of claim 12.
Claim 28
Dependent Claim
9 words
A product produced by the process of claim 13.
Claim 29
Dependent Claim
9 words
A product produced by the process of claim 14.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |