US4178372A
Expired / Lapsed
US
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Hypoallergenic stabilized aloe vera gel
Assignee: Individual
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Filing: 1978-03-06
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Granted: 1979-12-11
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Expires: 1998-03-06
Abstract
Abstract The clear gel of aloe vera leaves is processed to provide a durable preparation preserving the therapeutic qualities of the fresh gel while essentially eliminating the rare but important idiosyncratic sensitivities encountered from stabilized aloe vera gel of the prior art. The process includes mechanically separating the aloe vera gel matrix from the leaf itself and thereafter adding a catalytic amount of a non-toxic oxidant to the fresh gel which is brought to a temperature of from about 35 degrees C. to about 80 degrees C. Ascorbic acid is then employed as a non-toxic antioxidant to arrest catalytic oxidation and a non-toxic buffer is then added in order to maintain the pH of the stabilized gel composition in a range of from about 4 to about 6. The resulting stabilized aloe vera gel composition closely approaches a nonallergenic status which is a substantial improvement over established aloe vera gels available heretofore, making it especially useful for application to facial areas where such sensitivities are more likely to appear in those few patients who are susceptible. Since treatment of such patients with any effective medication is often problematical, avoidance of interfering sensitivities is of special significance and highly desirable.
Inventors
- 👤 Billy C. Coats
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 01:03
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K36/00; A61K36/18; A61K36/88; A61K36/886; A61K47/00; A61K47/46; A61K8/00; A61K8/02; A61K8/04; A61K8/042; A61K8/18; A61K8/96; A61K8/97; A61K8/9783; A61K8/9794; A61P; A61P1/00; A61P1/10; A61Q; A61Q19/00; A61K2800/00; A61K2800/40; A61K2800/52; A61K2800/522; A61K2800/70; A61K2800/72
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
148 words
A process for stabilizing a clear gel from the leaf of aloe vera comprising: (a) mechanically separating aloe vera gel matrix from the outer cortex of aloe vera leaf; (b) extruding said gel matrix through a filter to thereby remove particles of aloe vera leaf therefrom; (c) heating said aloe vera gel matrix to a temperature within the range of from about 35 degrees C. to about 80 degrees C. and adding thereto a catalytic amount of hydrogen peroxide to thereby cause said gel to oxidize and assume a lighter appearance; (d) adding ascorbic acid to said gel in an amount of from about 0.015 to about 0.5 ounce per gallon of said gel to thereby arrest catalytic oxidation; (e) adding an amount of citric acid to said gel effective to maintain the pH of said gel solution at a value of between from about 4 to 6.
Claim 2
Dependent Claim
148 words
A process for stabilizing a clear gel from the leaf of aloe vera comprising: (a) mechanically separating aloe vera gel matrix from the outer cortex of aloe vera leaf; (b) extruding said gel matrix through a filter to thereby remove particles of aloe vera leaf therefrom; (c) heating said aloe vera gel matrix to a temperature within the range of from about 35 degrees C. to about 80 degrees C. and adding thereto a catalytic amount of hydrogen peroxide to thereby cause said gel to oxidize and assume a lighter appearance; (d) adding ascorbic acid to said gel in an amount of from about 0.015 to about 0.5 ounce per gallon of said gel to thereby arrest catalytic oxidation; (e) adding an amount of citric acid to said gel effective to maintain the pH of said gel solution at a value of between from about 4 to 6.
Claim 3
Dependent Claim
28 words
The process of claim 1 wherein said hydrogen peroxide is added in an amount of from about 0.015 to about 0.03 ounce per gallon of aloe vera gel.
Claim 4
Dependent Claim
28 words
The process of claim 1 wherein said citric acid is added in an amount of from about 0.4 to about 0.8 ounce per gallon of aloe vera gel.
Claim 5
Dependent Claim
19 words
The process of claim 1 and further comprising adding to said stabilized gel composition an aqueous solution of sorbitol.
Claim 6
Dependent Claim
18 words
The process of claim 1 further comprising adding from about 0.2 to about 0.4 ounce of sodium benzoate.
Claim 7
Dependent Claim
24 words
The process of claim 1 further comprising adding from about 0.009 to about 0.027 ounce of cetyl alcohol per gallon of aloe vera gel.
Claim 8
Dependent Claim
24 words
The process of claim 1 further comprising adding from about 3.8 to about 5.1 ounces of ethyl alcohol per gallon of aloe vera gel.
Claim 9
Dependent Claim
24 words
The process of claim 1 and further comprising adding an effective proportion of tocopherol to prevent color change in the stabilized gel after processing.
Claim 10
Dependent Claim
31 words
The process of claim 8 wherein said tocopherol is vitamin E which is added in an amount of from about 0.0075 to about 0.03 ounce per gallon of aloe vera gel.
Claim 11
Dependent Claim
31 words
The process of claim 1 wherein said citric acid is added in an amount effective to maintain the pH of the composition in a range of about 4.6 to about 4.9.
Claim 12
Dependent Claim
9 words
The product produced by the process of claim 1.
Claim 13
Dependent Claim
213 words
The process for producing a stabilized hypoallergenic aloe vera gel composition comprising: (a) mechanically separating the nonbruised and nondiscolored aloe vera gel matrix from the outer green cortex of the aloe vera leaf; (b) extruding said aloe vera gel matrix through a filter screen to thereby remove particles of aloe vera leaf therefrom; (c) heating said gel to a temperature within the range of from about 35 degrees C. to about 80 degrees C. and adding thereto a sufficient portion of hydrogen peroxide to effect catalytic oxidation; (d) allowing said heated gel to cool to ambient temperature and adding thereto ascorbic acid in an amount of from about 0.015 to about 0.5 ounce per gallon of aloe vera gel to thereby arrest said catalytic oxidation; (e) adding a sufficient quantity of citric acid to maintain the pH of the composition between from about 4 to about 6; (f) thereafter adding from about 4.7 to about 9.4 ounces of a 70% solution of sorbitol, from about 0.2 to about 0.4 ounce sodium benzoate, from about 0.0075 to about 0.03 ounce of vitamin E, from about 0.009 to about 0.027 ounce of cetyl alcohol and from about 3.8 to about 5.1 ounces of ethyl alcohol, said additions being made per gallon of aloe vera gel.
Claim 14
Dependent Claim
213 words
The process for producing a stabilized hypoallergenic aloe vera gel composition comprising: (a) mechanically separating the nonbruised and nondiscolored aloe vera gel matrix from the outer green cortex of the aloe vera leaf; (b) extruding said aloe vera gel matrix through a filter screen to thereby remove particles of aloe vera leaf therefrom; (c) heating said gel to a temperature within the range of from about 35 degrees C. to about 80 degrees C. and adding thereto a sufficient portion of hydrogen peroxide to effect catalytic oxidation; (d) allowing said heated gel to cool to ambient temperature and adding thereto ascorbic acid in an amount of from about 0.015 to about 0.5 ounce per gallon of aloe vera gel to thereby arrest said catalytic oxidation; (e) adding a sufficient quantity of citric acid to maintain the pH of the composition between from about 4 to about 6; (f) thereafter adding from about 4.7 to about 9.4 ounces of a 70% solution of sorbitol, from about 0.2 to about 0.4 ounce sodium benzoate, from about 0.0075 to about 0.03 ounce of vitamin E, from about 0.009 to about 0.027 ounce of cetyl alcohol and from about 3.8 to about 5.1 ounces of ethyl alcohol, said additions being made per gallon of aloe vera gel.
Claim 15
Dependent Claim
28 words
The process of claim 12 wherein said hydrogen peroxide is added in an amount of from about 0.015 to about 0.03 ounce per gallon of aloe vera gel.
Claim 16
Dependent Claim
24 words
The process of claim 12 wherein sufficient citric acid is added to maintain the pH of the composition between about 4.4 to about 4.9.
Claim 17
Dependent Claim
144 words
In a process for stabilizing a clear gel from the leaf of the aloe vera, which includes the steps of mechanically separating the aloe vera gel matrix from the outer cortex of the aloe vera leaf, filtering particles of the aloe vera leaf from the gel matrix, heating the aloe vera gel matrix to temperatures of from about 35 degrees to about 80 degrees and adding a catalytic amount of hydrogen peroxide to cause the gel to oxidize and assume a lighter appearance, the improvement comprising: adding ascorbic acid to said gel in an amount of from about 0.015 to about 0.5 ounce per gallon of said gel to thereby arrest catalytic oxidation and adding an amount of citric acid to said gel which is effective to maintain the pH of the gel at a value of between from about 4 to about 6.
Claim 18
Dependent Claim
144 words
In a process for stabilizing a clear gel from the leaf of the aloe vera, which includes the steps of mechanically separating the aloe vera gel matrix from the outer cortex of the aloe vera leaf, filtering particles of the aloe vera leaf from the gel matrix, heating the aloe vera gel matrix to temperatures of from about 35 degrees to about 80 degrees and adding a catalytic amount of hydrogen peroxide to cause the gel to oxidize and assume a lighter appearance, the improvement comprising: adding ascorbic acid to said gel in an amount of from about 0.015 to about 0.5 ounce per gallon of said gel to thereby arrest catalytic oxidation and adding an amount of citric acid to said gel which is effective to maintain the pH of the gel at a value of between from about 4 to about 6.
References Cited (Backward Citations)
US3892853A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-10 | 1983-06-11 | 1983-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-10 | 1987-06-11 | 1987-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-10 | 1991-06-11 | 1991-12-11 | $7700.00 | Window Closed / Lapsed |