Patent US4849228A successfully refreshed from Google Patents.
US4849228A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymer, production and use thereof
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1987-11-06
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Granted: 1989-07-18
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Expires: 2007-11-06
Abstract
Abstract The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer. The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an exipient for pharmaceutical preparations.
Inventors
- 👤 Masaki Yamamoto
- 👤 Hiroaki Okada
- 👤 Yasuaki Ogawa
- 👤 Tsutomu Miyagawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:28
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/02; C08G63/06; A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031; B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/12; B01J13/125
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
96 words
A microcapsule for injectable sustained release which contains an effective amount of ingredient and a biodegradable high molecular polymer useful as an excipient in producing a pharmaceutical preparation comprising a copolymer or homopolymer of about 50-100 mole percent of lactic acid and about 50-0 mole percent of glycolic acid having a weight average molecular weight of about 2,000 to 50,000 and wherein the content of water-soluble low molecular compounds, as calculated on the assumption that each of said compounds is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.
Claim 2
Dependent Claim
96 words
A microcapsule for injectable sustained release which contains an effective amount of ingredient and a biodegradable high molecular polymer useful as an excipient in producing a pharmaceutical preparation comprising a copolymer or homopolymer of about 50-100 mole percent of lactic acid and about 50-0 mole percent of glycolic acid having a weight average molecular weight of about 2,000 to 50,000 and wherein the content of water-soluble low molecular compounds, as calculated on the assumption that each of said compounds is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.
Claim 3
Dependent Claim
13 words
The microcapsule according to claim 1, wherein the ingredient is a water-soluble peptide.
Claim 4
Dependent Claim
22 words
The microcapsule according to claim 2, wherein the water-soluble peptide has luteinizing hormone releasing hormone-like activity or thyroid hormone releasing hormone-like activity.
Claim 5
Dependent Claim
21 words
The microcapsule according to claim 3, wherein the peptide having the luteinizing hormone releasing hormone-like activity has the formula: (Pyr)Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHCH.sub.2 CH.sub.3.
Claim 6
Dependent Claim
39 words
The microcapsule according to claim 1, wherein the biodegradable high molecular polymer has an inherent viscosity of about 0.05-0.5 dl/g as determined with a 0.5 weight percent chloroform solution thereof and a weight average molecular weight of about 5,000-35,000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-17 | 1993-01-16 | 1993-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-17 | 1997-01-16 | 1997-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-17 | 2001-01-16 | 2001-07-18 | $7700.00 | Window Closed / Lapsed |