Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments

Claim 1

A therapeutic composition comprising an effective anti-hypersensitive amount of a compound of the formula (R.sub.1)(R.sub.2)Ar--Z--M--Z.sub.1 --Ar.sub.1 (R.sub.3)(Z.sub.2 --Y--Z.sub.3 --R.sub.4) wherein Ar is quinoline or isoquinoline; Ar 1 is phenyl; R 1 , R 2 , and R 3 are independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy-lower alkyl, alkyl carboxy, carboxy, formyl, lower alkyl carbonyl, aryl, aryloxy, benzyloxy, lower alkylamino, diloweralkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-lower alkoxy, lower carbalkoxy-lower alkoxy, nitro, amino, tetrahydro-pyranylmethyl, or tetrazole, or tetrazole lower alkyl; R 4 is ##STR40## R 7 is H, lower alkyl, ##STR41## R 8 is H or lower alkyl; each M is independently O, S, or NR 8 ; m is 0 to 5; n is 0 or 1; X is O, S, NR 8 ; Z, Z 1 , Z 2 , and Z 3 are independently a chemical bond or an alkylene chain containing up to 5 carbon atoms in the principal chain and up to a total of 8 carbon atoms; Y is a chemical bond, O, S, NR, CO, CHOR 8 , CH═CH, CH 2 --CH═CH, COO--, or CH 2 ; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Claim 4

A method for the treatment of inflammatory or allergic conditions in mammals comprising the administration thereto of an effective therapeutic amount of a compound of the formula ##STR42## wherein: R 1 is hydrogen, alkyl having one to about 5 carbon atoms, halo, triflouromethyl, hydroxy, lower alkoxy, ##STR43## Z 2 and Z 3 are independently a chemical bond or --(CH 2 ) m --; Y is a chemical bond, oxy, carbonyl, carboxyl, hydroxymethylene or loweralkoxymethylene; R 7 is hydrogen, lower alkyl or (CH 2 ) m CO 2 R 8 ; R 8 is hydrogen or lower alkyl; and m is 0-5; or a pharmaceutically acceptable acid addition salt thereof.

Claim 5

A method for the treatment of inflammatory or allergic conditions in mammals comprising the administration thereto of an effective therapeutic amount of a compound of the formula ##STR42## wherein: R 1 is hydrogen, alkyl having one to about 5 carbon atoms, halo, triflouromethyl, hydroxy, lower alkoxy, ##STR43## Z 2 and Z 3 are independently a chemical bond or --(CH 2 ) m --; Y is a chemical bond, oxy, carbonyl, carboxyl, hydroxymethylene or loweralkoxymethylene; R 7 is hydrogen, lower alkyl or (CH 2 ) m CO 2 R 8 ; R 8 is hydrogen or lower alkyl; and m is 0-5; or a pharmaceutically acceptable acid addition salt thereof.