US4661499A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-[(substituted)-phenoxymethyl]quinolines
Assignee: Merck Frosst Canada and Co
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Filing: 1985-06-18
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Granted: 1987-04-28
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Expires: 2005-06-18
Abstract
Abstract Compounds having the formula: <IMAGE> are selective antagonists of leukotrienes of D4 and inhibitors of the syntheses of LTA4, B4, C4, D4, E4, and F4. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, and cytoprotective agents.
Inventors
- 👤 Robert N. Young
- 👤 Robert Zamboni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 00:23
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/12; C07D215/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
101 words
A compound of the formula: ##STR4## wherein: R 1 is H, halogen, C 1 -C 6 alkyl, --CF 3 , --OR 2 , --SR 2 , --CHO, --COOR 2 , --(C═O)R 2 , --C(OH)R 2 R 2 , --CN, --NO 2 , unsubstituted phenyl, unsubstituted benzyl, or unsubstituted phenethyl; R 2 is H or C 1 -C 6 alkyl, R 3 is --OR 4 , --SR 4 , or --NR 4 R 4 ; R 4 is H, or C 1 -C 6 alkyl, --(C═O)R 2 , unsubstituted phenyl, or unsubstituted benzyl; m is 1-6; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
101 words
A compound of the formula: ##STR4## wherein: R 1 is H, halogen, C 1 -C 6 alkyl, --CF 3 , --OR 2 , --SR 2 , --CHO, --COOR 2 , --(C═O)R 2 , --C(OH)R 2 R 2 , --CN, --NO 2 , unsubstituted phenyl, unsubstituted benzyl, or unsubstituted phenethyl; R 2 is H or C 1 -C 6 alkyl, R 3 is --OR 4 , --SR 4 , or --NR 4 R 4 ; R 4 is H, or C 1 -C 6 alkyl, --(C═O)R 2 , unsubstituted phenyl, or unsubstituted benzyl; m is 1-6; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
18 words
A compound of claim 1 wherein R 2 is H, R 3 or OH, and m is 4.
Claim 4
Dependent Claim
7 words
The compound of claim 1: 2-[4-(1-hydroxyhexyl)phenoxymethyl)] quinoline.
Claim 5
Dependent Claim
29 words
A pharmaceutical composition useful in antagonizing leukotriene action in mammals comprising an amount of a compound of claim 1 effective as a leukotriene antagonist and a pharmaceutically acceptable carrier
Claim 6
Dependent Claim
15 words
A pharmaceutical composition of claim 4 useful in antagonizing leukotriene D 4 action in mammals.
Claim 7
Dependent Claim
35 words
A method of preventing the synthesis, the action, or the release of SRS-A and leukotriene D 4 , in mammals, which comprises administering to said mammal an effective amount of a compound of claim 1.
Claim 8
Dependent Claim
11 words
The method of claim 6 wherein leukotriene D 4 is affected.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-27 | 1990-10-27 | 1991-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-27 | 1994-10-27 | 1995-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-27 | 1998-10-27 | 1999-04-28 | $7700.00 | Window Closed / Lapsed |