High temperature, short time heating system and method of sterilizing or pasteurizing heat sensitive biological fluids

Claim 3

The method of claim 1 wherein said dielectric constant of said heat-sensitive biological fluid is obtained by adding a dielectric enhancing additive prior to said heating step.

Claim 4

The method of claim 2 which further includes removing at least a portion of the dielectric enhancing additive from the cooled biological fluid.

Claim 5

The method of claim 1 wherein said dielectric constant of said heat-sensitive biological fluid is obtained by adding a dielectric enhancing additive of an ionic salt in an amount of about 0.1% to 10% by weight prior to said heating step.

Claim 6

The method of claim 1 wherein said preselected heating temperature is at least about 60° C. and said holding time period is at most about 0.05 seconds.

Claim 7

The method of claim 1 wherein said preselected heating temperature is at least about 143° C. and said holding time period is at most about 0.05 seconds.

Claim 8

The method of claim 1 wherein the heat-sensitive biological fluid is selected from the group consisting of body fluids, mother's milk, vaccines, fermentation broths and microbiological and cell media.

Claim 9

The method of claim 1 wherein said heating of the biological fluid at a rate of about 50° C. to 8,000° C. per second.

Claim 10

The method of claim 1 wherein the biological fluid comprises blood plasma or serum and which includes heating the blood plasma or serum to a selected temperature of over about 75° C. and said holding time period is at most about 0.05 seconds.

Claim 11

The method of claim 1 wherein said cooler temperature is at most about 20° C.

Claim 12

The method of claim 1 which includes circulating the said biological fluid at a flow rate of about 3 to 25 liters per hour with a hold-up volume of less than about 0.5 liters.

Claim 15

The method of claim 12 wherein includes heating the blood plasma or serum at a rate of about 50° C. to 4000° C. per second.

Claim 16

The method of claim 12 wherein said holding time period should be less than about 0.05 seconds and wherein said method further includes rapidly cooling the blood plasma or serum after said heating step.

Claim 17

The method of claim 14 wherein said selected temperature is at least 75° C. to provide a sterilized blood plasma or serum.

Claim 18

The method of claim 12 which further includes separating from the blood plasma or serum at least a part of the dielectric salt subsequent to said heating.

Claim 19

The method of claim 1 wherein the infectious agent comprises a virus.

Claim 20

A high temperature, short time heat process system for the rapid heating, holding and cooling of a heat-sensitive biological fluid to destroy undesirable biological agents therein without substantial alteration of desirable proteinaceous components or properties of the biological fluid, which system comprises: (a) a source of heat-sensitive biological fluid to be heated; (b) a source of dielectric enhancing additive for addition to the biological fluid in an amount sufficient to increase the dielectric constant of said biological fluid to a dielectric constant of over about 90; (c) microwave heating energy means to heat rapidly for a heating time period said biological fluid at a rate of about 25° C. to 8,000° C. per second to a preselected heating temperature for a holding time period of up to about two seconds; (d) cooling means to cool rapidly the heated biological fluid to a preselected cooler temperature in a cooling time period to provide a cooled biological fluid; (e) circulating means within the microwave heating energy means and cooling means to permit the flow of said biological fluid through said microwave heating energy means in a microwave heating relationship and through the cooling means in a cooling relationship; (f) pump means to pump said biological fluid through said circulating means; and (g) means to recover the cooled biological fluid.

Claim 21

A high temperature, short time heat process system for the rapid heating, holding and cooling of a heat-sensitive biological fluid to destroy undesirable biological agents therein without substantial alteration of desirable proteinaceous components or properties of the biological fluid, which system comprises: (a) a source of heat-sensitive biological fluid to be heated; (b) a source of dielectric enhancing additive for addition to the biological fluid in an amount sufficient to increase the dielectric constant of said biological fluid to a dielectric constant of over about 90; (c) microwave heating energy means to heat rapidly for a heating time period said biological fluid at a rate of about 25° C. to 8,000° C. per second to a preselected heating temperature for a holding time period of up to about two seconds; (d) cooling means to cool rapidly the heated biological fluid to a preselected cooler temperature in a cooling time period to provide a cooled biological fluid; (e) circulating means within the microwave heating energy means and cooling means to permit the flow of said biological fluid through said microwave heating energy means in a microwave heating relationship and through the cooling means in a cooling relationship; (f) pump means to pump said biological fluid through said circulating means; and (g) means to recover the cooled biological fluid.

Claim 22

The system of claim 18 which further includes a means to separate from the cooled biological fluid at least part of the dielectric enhancing additive.

Claim 23

The system of the claim 18 which includes a divert valve means to provide for the diversion of biological fluid circulated through the circulating means and microwave heating energy means in the event the biological fluid has not reached the preselected temperature for the holding time period.

Claim 24

The system of claim 18 which includes a back pressure valve means to prevent the vaporization in the system of the heated biological fluid.