US4251437A
Expired / Lapsed
US
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Process for producing an antihemophilic factor preparation from human blood plasma by irradiating with electromagnetic waves
Assignee: Nordisk Insulinlaboratorium
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Filing: 1979-10-26
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Granted: 1981-02-17
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Expires: 1999-10-26
Abstract
Abstract An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 108-1015 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10 DEG C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 108-3x1011 Hz, in particular 2x109-3x1010 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance.
Inventors
- 👤 Mirella E. Rasmussen
- 👤 Jorgen V. Jensen
- 👤 Jorgen F. Hansen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 09:55
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61K; A61K38/00; H; H01; H01R; H01R13/00; H01R13/46; H01R13/52; H01R13/5219; H01R13/5221; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
88 words
A process for producing an antihemophilic factor preparation (AHF) comprising the steps of thawing deep-frozen human blood plasma, at least partially, by irradiation with electromagnetic waves of a frequency of about 10 8 -10 15 Hz for a period of time and with an energy penetration such that the temperature in the thawed blood plasma does not exceed b 10° C. at any point, centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer, isolating a concentrated solution, and optionally freeze-drying the concentrated solution.
Claim 2
Dependent Claim
88 words
A process for producing an antihemophilic factor preparation (AHF) comprising the steps of thawing deep-frozen human blood plasma, at least partially, by irradiation with electromagnetic waves of a frequency of about 10 8 -10 15 Hz for a period of time and with an energy penetration such that the temperature in the thawed blood plasma does not exceed b 10° C. at any point, centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer, isolating a concentrated solution, and optionally freeze-drying the concentrated solution.
Claim 3
Dependent Claim
27 words
A process according to claim 1, wherein the irradiation is controlled so that the temperature in the thawed product does not exceed 4° C. at any point.
Claim 4
Dependent Claim
24 words
A process according to claim 1, wherein the irradiation is carried out with microwaves of a frequency of about 10 8 -3×10 11 Hz.
Claim 5
Dependent Claim
24 words
A process according to claim 1, wherein the irradiation is carried out with microwaves of a frequency of about 2×10 9 -3×10 10 Hz.
Claim 6
Dependent Claim
89 words
An antihemophilic factor preparation (AHF) of high solubility and long half-life which has been recovered by thawing deep-frozen human blood plasma, at least partially, by irradiation with electromagnetic waves of a frequency of about 10 8 -10 15 Hz for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10° C. at any point, centrifuging the thawed product to form a cryoprecipitate, redissolving the precipitate in a buffer, isolating a concentrated solution and optionally freeze-drying said concentrated solution.
Claim 7
Dependent Claim
89 words
An antihemophilic factor preparation (AHF) of high solubility and long half-life which has been recovered by thawing deep-frozen human blood plasma, at least partially, by irradiation with electromagnetic waves of a frequency of about 10 8 -10 15 Hz for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10° C. at any point, centrifuging the thawed product to form a cryoprecipitate, redissolving the precipitate in a buffer, isolating a concentrated solution and optionally freeze-drying said concentrated solution.
Claim 8
Dependent Claim
27 words
An antihemophilic factor preparation according to claim 5, wherein the thawing has been effected by irradiation with microwaves of a frequency of 10 8 -3×10 11 Hz.
Claim 9
Dependent Claim
27 words
An antihemophilic factor preparation according to claim 5, wherein the thawing has been effected by irradiation with microwaves of a frequency of 2×10 9 -3×10 10 Hz.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-17 | 1984-08-18 | 1985-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-17 | 1988-08-18 | 1989-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-17 | 1992-08-18 | 1993-02-17 | $7700.00 | Window Closed / Lapsed |