US4837014A
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US
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An improved method of treating sickle cell anemia
Assignee: Emory University
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Filing: 1989-01-13
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Granted: 1989-06-06
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Expires: 2009-01-13
Abstract
Abstract In accordance with the present invention, a method is provided that is effective in treating sickle cell anemia. The method comprises a method of treating a person with sickle cell disease comprising the step of injecting into the person with sickle cell disease a solution with an effective concentration of a surface active copolymer of the following formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.
Inventors
- 👤 Robert L. Hunter
- 👤 Alexander Duncan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:58
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/446; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61K31/00; A61K31/74; A61K31/765; A61K38/164; A61K38/166; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
113 words
A method of treating a person with sickle cell disease comprising the step of injecting into the person with sickle cell disease a solution with a fibrinolytic composition therein, the composition comprising an effective concentration of a fibrinolytic enzyme and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 2
Independent Claim
113 words
A method of treating a person with sickle cell disease comprising the step of injecting into the person with sickle cell disease a solution with a fibrinolytic composition therein, the composition comprising an effective concentration of a fibrinolytic enzyme and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 3
Dependent Claim
49 words
The method of claim 1 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) Is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 4
Independent Claim
98 words
A method of treating a person with sickle cell disease comprising the step of injecting into the person with sickle cell disease a solution comprising an effective concentration of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 5
Independent Claim
98 words
A method of treating a person with sickle cell disease comprising the step of injecting into the person with sickle cell disease a solution comprising an effective concentration of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 6
Dependent Claim
49 words
The method of claim 3 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-06-05 | 1992-12-05 | 1993-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-05 | 1996-12-05 | 1997-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-05 | 2000-12-05 | 2001-06-06 | $7700.00 | Window Closed / Lapsed |