Spray dried ibuprofen

Claim 2

A therapeutic taste neutral powder form of spray-dried ibuprofen which consists essentially of, based upon the weight of the powder, about 40% to 70% by weight ibuprofen, about 15% to 50% by weight of cellulose acetate phthalate and about 5% to 40% by weight colloidal silica, the powder having been spray dried from a suspension of the colloidal silica in a lower alkanol solution of the ibuprofen and the cellulose material, the lower alkanol being mixed with up to 50% ethyl acetate.

Claim 3

In a pharmaceutical dosage form for oral administration as a solid, which dosage form can be disintegrated by water within ten seconds, the improvement which comprises incorporating into such dosage form as the pharmaceutical substance a therapeutic taste-neutral powder form of spray-dried ibuprofen which consists essentially of, based upon the weight of the powder, about 40% to 70% by weight ibuprofen, about 15% to 50% by weight of acetate phthalate cellulose and about 5% to 40% by weight colloidal silica, the powder having been spray dried from a suspension of the colloidal silica in a lower alkanol solution of the ibuprofen and the cellulose material, the lower alkanol being mixed with up to 50% ethyl acetate.

Claim 4

In a pharmaceutical dosage form for oral administration as a solid, which dosage form can be disintegrated by water within ten seconds, the improvement which comprises incorporating into such dosage form as the pharmaceutical substance a therapeutic taste-neutral powder form of spray-dried ibuprofen which consists essentially of, based upon the weight of the powder, about 40% to 70% by weight ibuprofen, about 15% to 50% by weight of acetate phthalate cellulose and about 5% to 40% by weight colloidal silica, the powder having been spray dried from a suspension of the colloidal silica in a lower alkanol solution of the ibuprofen and the cellulose material, the lower alkanol being mixed with up to 50% ethyl acetate.

Claim 5

The taste neutral powder of claim 1 wherein the lower alkanol is isopropyl alcohol.

Claim 6

The dosage form of claim 2 wherein the lower alkanol is isopropyl alcohol.

Claim 7

In a pharmaceutical dosage form for oral administration as a solid chewable taste-neutral tablet containing ibuprofen, the improvement which comprises incorporating into such tablet as the pharmaceutical substance a therapeutic taste-neutral powder form of spray-dried ibuprofen which consists essentially of, based upon the weight of the powder, about 40% to 70% ibuprofen, about 15% to 50% by weight of cellulose acetate phthalate, and about 5% to 40% by weight cooloidal silica, the powder having been spray dried from a suspension of the colloidal silica in a lower alkanol solution of the ibuprofen and the cellulose acetate phthalate, the lower alkanol containing up to 50% ethyl acetate.

Claim 8

In a pharmaceutical dosage form for oral administration as a solid chewable taste-neutral tablet containing ibuprofen, the improvement which comprises incorporating into such tablet as the pharmaceutical substance a therapeutic taste-neutral powder form of spray-dried ibuprofen which consists essentially of, based upon the weight of the powder, about 40% to 70% ibuprofen, about 15% to 50% by weight of cellulose acetate phthalate, and about 5% to 40% by weight cooloidal silica, the powder having been spray dried from a suspension of the colloidal silica in a lower alkanol solution of the ibuprofen and the cellulose acetate phthalate, the lower alkanol containing up to 50% ethyl acetate.

Claim 9

The dosage form of claim 5 wherein the lower alkanol is isopropyl alcohol.