US4726966A
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Preparation of coated granular ibuprofen microsphere
Assignee: Showa Yakuhin Kako Co Ltd
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Filing: 1986-11-25
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Granted: 1988-02-23
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Expires: 2006-11-25
Abstract
Abstract This invention provides a simple method for preparing granular ibuprofen microsphere whose surface is coated with acrylic acid resin. By this method granulation of ibuprofen and coating of its surface can be simultaneously accomplished. Namely, the method of preparation includes the steps of: (a) dissolving ibuprofen with acrylic acid resin into lower aliphatic alcohol, acetone, methylene chloride or N,N-dimethylformamide; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.
Inventors
- 👤 Yoshiaki Kawashima
- 👤 Hirofumi Takeuchi
- 👤 Toshiyuki Niwa
- 👤 Tetsurou Handa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:45
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026; A61K31/00; A61K31/185; A61K31/19; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
46 words
A method for preparing coated granular ibuprofen microsphere, the method comprising of the following steps: (a) dissolving ibuprofen with acrylic acid resin in ethanol; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.
Claim 2
Independent Claim
46 words
A method for preparing coated granular ibuprofen microsphere, the method comprising of the following steps: (a) dissolving ibuprofen with acrylic acid resin in ethanol; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.
Claim 3
Dependent Claim
29 words
The method as claimed in claim 1, wherein the acrylic acid resin is an enteric film coating agent or a retard film coating agent which is soluble in water.
Claim 4
Dependent Claim
33 words
The method as claimed in claim 2 wherein the acrylic acid resin is a copolymer of an acrylate or a methacrylate or a quaternary ammonium group-containing copolymer of an acrylate or a methacrylate.
Claim 5
Dependent Claim
23 words
The method as claimed in claim 3, wherein the molar ratio of an acid:ester of acrylate or a methacrylate is 1:1 to 1:2.
Claim 6
Dependent Claim
25 words
The method as claimed in claim 3, wherein the molar ratio of an ammonium group: ester of acrylate or a methacrylate is 1:20 to 1:40.
Claim 7
Dependent Claim
24 words
The method as claimed in claim 1, wherein the amount of acrylic acid resin is 2 to 100 wt % with respect to ibuprofen.
Claim 8
Dependent Claim
22 words
The method as claimed in claim 1, wherein the concentration of ibuprofen in the ethanol solution is 10 to 50 wt %.
Claim 9
Dependent Claim
27 words
The method as claimed in claim 1, wherein the amount of water added is over 300 wt % with respect to the ethanol solution in step (b).
Claim 10
Dependent Claim
15 words
The method as claimed in claim 1, wherein a surfactant is present in step (b).
Claim 11
Dependent Claim
29 words
The method as claimed in claim 9, wherein the acrylic acid resin is an enteric film coating agent or a retard film coating agent which is soluble in water.
Claim 12
Dependent Claim
33 words
The method as claimed in claim 10, wherein the acrylic acid resin is a copolymer of an acrylate or a methacrylate or a quaternary ammonium group-containing copolymer of an acrylate or a methacrylate.
Claim 13
Dependent Claim
23 words
The method as claimed in claim 11, wherein the molar ratio of an acid:ester of acrylate or a methacrylate is 1:1 to 1:2.
Claim 14
Dependent Claim
24 words
The method as claimed in claim 11, wherein the molar ratio of an ammonium group:ester of acrylate or a methacrylate is 1:20 to 1:40.
Claim 15
Dependent Claim
24 words
The method as claimed in claim 9, wherein the amount of acrylic acid resin is 2 to 100 wt % with respect to ibuprofen.
Claim 16
Dependent Claim
22 words
The method as claimed in claim 9, wherein the concentration of ibuprofen in the ethanol solution is 10 to 50 wt %.
Claim 17
Dependent Claim
27 words
The method as claimed in claim 9, wherein the amount of water added is over 300 wt % with respect to the ethanol solution in step (b).
Claim 18
Dependent Claim
17 words
The method as claimed in claim 9, wherein HLB value of the surfactant is 6 to 15.
Claim 19
Dependent Claim
24 words
The method as claimed in claim 9, wherein the amount of the surfactant added is 0.2 to 8 wt % with respect to ibuprofen.
Claim 20
Dependent Claim
14 words
The method as claimed in claim 9, wherein said surfactant is sucrose-fatty acid ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-22 | 1991-08-24 | 1992-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-22 | 1995-08-24 | 1996-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-22 | 1999-08-24 | 2000-02-23 | $7700.00 | Window Closed / Lapsed |