EP0190826A2
Expired / Lapsed
EP
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Ingestible aggregate and delivery system incorporating the same
Assignee: Warner Lambert Co LLC
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Filing: 1986-01-15
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Granted: —
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Expires: 2006-01-15
Abstract
Abstract The present invention relates to an ingestible aggregate comprising a pre-swelled substantially anhydrous hydrocolloid and a substrate. More particularly this invention relates to an aggregate having as a substrate a dietary fiber and/or drug wherein the composition can be administered in a therapeutically effective amount Hydrocolloids useful include natural and modified gums, celluloses, modified celluloses, pectins, mucillages, modified starches, noncellulose polysaccharides, algal polysaccharides and mixtures thereof. The aggregate should be in the size range of about 4 to about 70 U.S. mesh. The unpleasant taste and mouthfeel of the fiber and/or drug is effectively masked and substantial hydration is delayed until the compositions reaches the stomach. The compositions are substantially more palatable, devoid of graininess, bitterness or fibrous texture. The pleasant taste of the composition encourages patient compliance with their fiber or drug therapy.
Inventors
- 👤 James J. Shaw
- 👤 Shri C. Sharma
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 09:44
CPC Classifications
A; A23; A23G; A23G3/00; A23G3/34; A23G3/36; A23G3/364; A23G3/368; A23L; A23L33/00; A23L33/20; A23L33/21; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047; A61K9/5073; Y; Y10; Y10S; Y10S426/00; Y10S426/804
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
47 words
An ingestible substantially anhydrous aggregate comprising a pre-swelled hydrocolloid and a solid substrate, wherein the hydrocolloid at least partially entraps and binds the substrate, the substrate being selected from dietary fibers, drugs and mixtures thereof, and wherein the substrate and the hydrocolloid are not the identical material.
Claim 2
Dependent Claim
47 words
An ingestible substantially anhydrous aggregate comprising a pre-swelled hydrocolloid and a solid substrate, wherein the hydrocolloid at least partially entraps and binds the substrate, the substrate being selected from dietary fibers, drugs and mixtures thereof, and wherein the substrate and the hydrocolloid are not the identical material.
Claim 3
Dependent Claim
20 words
An aggregate according to Claim 1, wherein the aggregate size is in the range from 4 to 70 U.S. mesh.
Claim 4
Dependent Claim
32 words
An aggregate according to Claim 1 or 2, wherein the hydrocolloid is selected from natural and modified gums, cellulose, modified celluloses, pectin, mucillages, modified starches, noncellulosic polysaccarides, algal polysaccharides and mixtures thereof.
Claim 5
Dependent Claim
30 words
An aggregate according to Claim 3, wherein the hydrocolloid is selected from carboxymethyl cellulose, methyl cellulose, karaya gum, acacia gum, sodium alginate, calcium alginate, hydroxypropyl methyl cellulose and mixtures thereof.
Claim 6
Dependent Claim
26 words
An aggregate according to any preceding claim, wherein the dietary fiber is selected from non-cellulosic polysaccharides, pectin, gums, algal polysaccharides, cellulose, hemicellulose, lignin and mixtures thereof.
Claim 7
Dependent Claim
26 words
An aggregate according to any preceding claim, wherein the dietary fiber is selected from locust bean gum, guar gum, acacia gum, glucomannons, mucillages and mixtures thereof.
Claim 8
Dependent Claim
103 words
An aggregate according to any preceding claim, wherein the drug is selected from mineral supplements, analgesics, antipyretics, antiarrhythmics, ion exchange resins, appetite supressants, vitamins, anti-inflammatory substances, coronary dilators, cerebral dilators, peripheral vasaldilators, anti- -infectives, psychotropics, antimanics, stimulants, antihistamines, laxatives, decongestants, gastro-intestinal sedatives, antidiarrheal preparations, anti-anginal drugs, vasodilators, antiarrythmics, anti-hypertensive drugs, vasoconstrictors and migrane treatments, antibiotics, tranquilizers, antipsychotics, antitumor drugs, anti-coagulants and antithrombotic drugs, hypnotics, sedatives, anti-emetics, anti-nauseants, anticonvulsants, neuromuscular drugs, hyper and hypoglycaemic agents, thyroid and antithyroid preparations, diuretics, anti- -spasmodics, uterine relaxants, mineral and nutritional additives. antiobesity drugs, anabolic drugs, erythropcietic drugs, antiasthmatics, expectorants, cough suppressants, mucolytics, anti-uricemic drugs and mixtures thereof.
Claim 9
Dependent Claim
23 words
An aggregate according to Claim 7, wherein the drug is selected from potassium chloride, calcium carbonate, magnesium oxide, N-acetylprocainamide, cholestyramine and mixtures thereof.
Claim 10
Dependent Claim
23 words
An aggregate according to Claim 7 or 8, wherein the ratio of hydrocolloid to substrate is in the range from 1:200 to 1:1.
Claim 11
Dependent Claim
26 words
An aggregate according to Claim 8 when appendant to Claim 4, wherein the ratio of hydrocolloid to substrate is in the range from 3:1 to 20:1.
Claim 12
Dependent Claim
75 words
An aggregate according to Claim 1 or 2, consisting essentially of the pre-swelled substantially anhydrous hydrocolloid and the substrate, wherein the substrate is a soluble dietary fiber selected from locust bean gum, guar gum, acacia gum and mixtures thereof; and the hydrocolloid is selected from carboxymethyl cellulose, methyi cellulose, karaya gum, sodium alginate, calcium alginate, and mixtures thereof; and wherein the ratio of hydrocolloid to substrate is preferably in the range from 1:100 to 1:5.
Claim 13
Dependent Claim
18 words
A delivery system comprising (i) an edible matrix; and (ii) an ingestible aggregate according to any preceding claim.
Claim 14
Dependent Claim
39 words
A delivery system according to Claim 1 2, wherein the edible matrix is present in an amount in the range from 50% to 99.9%, preferably 50% to 99%, more preferably 50% to 85%, by weight of the delivery system.
Claim 15
Dependent Claim
40 words
A delivery system according to Claim 12 or 13, wherein the edible matrix is a confectionery composition; or comprises hydrogenate vegetable, chocolate and cocoa butter; or is a gel or nougat; or is a boiled candy; or is a liquid.
Claim 16
Dependent Claim
67 words
A process for producing an ingestible aggregate according to any one of Claims 1 to 11, the process comprising (a) preparing an aqueous composition of the hydrocolloid; (b) fluidizing the substantially anhydrous substrate particles in an air or other gaseous stream; (c) contacting the substrate particles with the aqueous hydrocolloid composition to form the aggregates of the substrate and hydrocolloid; and (d) drying and collecting the aggregates.
Claim 17
Dependent Claim
28 words
A process according to Claim 15, wherein the hydrocolloid is sprayed onto the substrate particles at a pressure of in the range from 1 bar to 5 bar.
Claim 18
Dependent Claim
36 words
A pharmaceutical preparation containing, in addition to a pharmaceutical carrier or diluent, an aggregate according to any one of Claims 1 to 11 or a delivery system according to any one of Claims 12 to 14.
Claim 19
Dependent Claim
7 words
Claims for the contracting state : AT
Claim 20
Dependent Claim
102 words
A process for producing an ingestible substantially anhydrous aggregate comprising a pre-swelled hydrocolloid and a solid substrate, wherein the hydrocolloid at least partially entraps and binds the substrate, the substrate being selected from dietary fibers, drugs and mixtures thereof, and wherein the substrate and the hydrocolloid are not the identical material, the process comprising (a) preparing an aqueous composition of the hydrocolloid; (b) fluidizing the substantially anhydrous substrate particles in an air or other geseous stream; (c) contacting the substrate particles with the aqueous hydrocolloid composition to form the aggregates of the substrate and hydrocolloid; and (d) drying and collecting the aggregates.
Claim 21
Dependent Claim
102 words
A process for producing an ingestible substantially anhydrous aggregate comprising a pre-swelled hydrocolloid and a solid substrate, wherein the hydrocolloid at least partially entraps and binds the substrate, the substrate being selected from dietary fibers, drugs and mixtures thereof, and wherein the substrate and the hydrocolloid are not the identical material, the process comprising (a) preparing an aqueous composition of the hydrocolloid; (b) fluidizing the substantially anhydrous substrate particles in an air or other geseous stream; (c) contacting the substrate particles with the aqueous hydrocolloid composition to form the aggregates of the substrate and hydrocolloid; and (d) drying and collecting the aggregates.
Claim 22
Dependent Claim
20 words
A process according to Claim 1, wherein the aggregate size is in the range from 4 to 70 U.S. mesh.
Claim 23
Dependent Claim
32 words
A process according to Claim 1 or 2, wherein the hydrocolloid is selected from natural and modified gums, cellulose, modified celluloses, pectin, mucillages, modified starches, noncellulosic polysaccarides, algal polysaccharides and mixtures thereof.
Claim 24
Dependent Claim
30 words
A process according to Claim 3, wherein the hydrocolloid is selected from carboxymethyl cellulose, methyl cellulose, karaya gum, acacia gum, sodium alginate, calcium alginate, hydroxypropyl methyl cellulose and mixtures thereof.
Claim 25
Dependent Claim
26 words
A process according to any preceding claim, wherein the dietary fiber is selected from non-cellulosic polysaccharides, pectin, gums, algal polysaccharides, cellulose, hemicellulose, lignin and mixtures thereof.
Claim 26
Dependent Claim
26 words
A process according to any preceding claim, wherein the dietary fiber is selected from locust bean gum, guar gum, acacia gum, glucomannons, mucillages and mixtures thereof.
Claim 27
Dependent Claim
101 words
A process according to any preceding claim, wherein the drug is selected from mineral supplements, analgesics, antipyretics, antiarrhythmics, ion exchange resins, appetite suppressants, vitamins, anti-inflammatory substances, coronary dilators, cerebral dilators, peripheral vasolidilators, anti--infectives, psychotropics, antimanics, stimulants, antihistamines, laxatives, decongestants, gastro-intestinal sedatives, antidiarrheal preparations, anti-anginal drugs, vasodilators, antiarrythmics, anti-hypertensive drugs, vasoconstrictors and migrane treatments, antibiotics, tranquilizers, antipsychotics, antitumor drugs, anti-coagulants and antithrombotic drugs, hypnotics, sedatives, anti-emetics, anti-nauseants, anticonvulsants, neuromuscular drugs, hyper and hypoglycaemic agents, thyroid and antithyroid preparations, diuretics, anti--spasmodics, uterine relaxants, mineral and nutritional additives, antiobesity drugs, anabolic drugs, erythropoietic drugs, antiasthmatics, expectorants, cough suppressants, mucolyfics, anti-uricemic drugs and mixtures thereof.
Claim 28
Dependent Claim
23 words
A process according to Claim 7, wherein the drug is selected from potassium chloride, calcium carbonate, magnesium oxide, N-acetylprocainamide, cholestyramine and mixtures thereof.
Claim 29
Dependent Claim
23 words
A process according to Claim 7 or 8, wherein the ratio of hydrocolloid to substrate is in the range from 1:200 to 1:1.
Claim 30
Dependent Claim
27 words
A process according to Claim 8 when appendant to Claim 4 , wherein the ratio of hydrocolloid to substrate is in the range from 3:1 to 20:1.
Claim 31
Dependent Claim
81 words
A process according to Claim 1 or 2 for producing an aggregate consisting essentially of the pre-swelled substan- tally anhydrous hydrocolloid and the substrate, wherein the substrate is a soluble dietary fiber selected from locust bean gum, guar gum, acacia gum and mixtures thereof; and the hydrocolloid is selected from carboxymethyl cellulose, meth- yf cellulose, karaya gum, sodium alginate, calcium alginate, and mixtures thereof and wherein the ratio of hydrocolloid to substrate is preferably in the range from 1:100 to 1.5.
Claim 32
Dependent Claim
29 words
A process according to any preceding claim, wherein the hydrocolloid is sprayed onto the substrate particles at a pressure of in the range from 1 bar to 5 bar.
Claim 33
Dependent Claim
32 words
A process for producing a delivery system comprising (i) an edible matrix; and (ii) an ingestible aggregate as defined in any preceding claim; the process comprising admixing the matrix and the aggregate.
Claim 34
Dependent Claim
40 words
1 4 . A process according to Claim 13, wherein the edible matrix is present in an amount in the range from 50% to 99.9%, preferably 50% to 99%, more preferably 50% to 85%, by weight of the delivery system.
Claim 35
Dependent Claim
40 words
A delivery system according to Claim 13 or 14, wherein the edible matrix is a confectionery composition; or comprises hydrogenate vegetable, chocolate and cocoa butter; or is a gel or nougat or is a boiled candy; or is a liquid.
Claim 36
Dependent Claim
56 words
A process for producing a pharmaceutical preparation containing, in addition to a pharmaceutical carrier or diluent, an aggregate as defined in any one of claims 1 to 12 or a delivery system as defined in any one of claims 13 to 15; which process comprises combining the diluent or carrier with the aggregate or delivery system.
References Cited (Backward Citations)
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