Patent US4833149A successfully refreshed from Google Patents.
US4833149A
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2- or 3-aryl substituted imidazo[1,2-a]pyridines
Assignee: Ortho Pharmaceutical Corp
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Filing: 1988-04-15
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Granted: 1989-05-23
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Expires: 2008-04-15
Abstract
Abstract Novel 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.
Inventors
- 👤 Jeffrey B. Press
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:06
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
113 words
A compound of the formula ##STR6## where X is hydrogen, halogen, hydroxy, alkoxy, benzyloxy, or C 1 -C 6 alkyl, one or more of; R is H or Ar; R 1 is H, CH 3 or Ar; Ar is ##STR7## Y is C 1 -C 3 alkyl or C 1 -C 3 alkoxy; p is 1 or 2; R 2 is C 1 -C 6 alkyl; n is 0 or 1 when R is Ar or 1 when R 1 is Ar; and m is 2-6, with the proviso that both R and R 1 are not Ar at the same time and at least one of R and R 1 is Ar.
Claim 2
Dependent Claim
113 words
A compound of the formula ##STR6## where X is hydrogen, halogen, hydroxy, alkoxy, benzyloxy, or C 1 -C 6 alkyl, one or more of; R is H or Ar; R 1 is H, CH 3 or Ar; Ar is ##STR7## Y is C 1 -C 3 alkyl or C 1 -C 3 alkoxy; p is 1 or 2; R 2 is C 1 -C 6 alkyl; n is 0 or 1 when R is Ar or 1 when R 1 is Ar; and m is 2-6, with the proviso that both R and R 1 are not Ar at the same time and at least one of R and R 1 is Ar.
Claim 3
Dependent Claim
19 words
A compound of claim 1 wherein X is hydrogen or methyl, R 2 is butyl and m is 3.
Claim 4
Dependent Claim
11 words
A compound of claim 2 wherein Y is methyl or methoxy.
Claim 5
Dependent Claim
17 words
A compound of claim 1 selected from the group consisting of 2-(4-(3-dibutylaminopropoxy)-3-methylphenyl)-8-methylimidazo[1,2-a]pyridine; 2-(4-(3-dipropylaminopropoxy)-3-methylphenyl)-8-methylimidazo[1,2-a]pyridine; 2-(4-(3-dibutylaminopropoxy)-2-methylphenyl)-8-methylimidazo[1,2-a]pyridine; 2-(4-(3-dibutylaminopropoxy)-3,5-dimethoxyphenyl)-8-methylimidazo[1,2-a]pyridine; and 2-(4-(3-dibutylaminopropoxy)-3-methoxyphenyl)-8-methylimidazo[1,2-a]pyridine.
Claim 6
Dependent Claim
30 words
A method for blocking calcium channels of a mammal which comprises administering to a mammal an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
30 words
A method for blocking calcium channels of a mammal which comprises administering to a mammal an effective amount of a compound of claim 2 or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
30 words
A method for blocking calcium channels of a mammal which comprises administering to a mammal an effective amount of a compound of claim 3 or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
30 words
A method for blocking calcium channels of a mammal which comprises administering to a mammal an effective amount of a compound of claim 4 or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
31 words
A method for inhibiting gastric acid secretion of a mammal which comprises administering to a mammal an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
31 words
A method for inhibiting gastric acid secretion of a mammal which comprises administering to a mammal an effective amount of a compound of claim 2 or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
31 words
A method for inhibiting gastric acid secretion of a mammal which comprises administering to a mammal an effective amount of a compound of claim 3 or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
31 words
A method for inhibiting gastric acid secretion of a mammal which comprises administering to a mammal an effective amount of a compound of claim 4 or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US4716169A
Cited
US4727145A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |