US4727145A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2- Or 3- aryl substituted imidazo [1,2-a]pyridines
Assignee: Ortho Pharmaceutical Corp
•
Filing: 1986-09-22
•
Granted: 1988-02-23
•
Expires: 2006-09-22
Abstract
Abstract Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents.
Inventors
- 👤 Jeffery B. Press
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:17
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P1/00; A61P1/04; A61P25/00; A61P25/02; A61P3/00; A61P3/12; A61P3/14; A61P9/00; A61P9/06
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
41 words
A compound of the formula ##STR7## where X is hydrogen, one or more of halogen, hydroxy, alkoxy having 1-3 carbon atoms, benzyloxy, or C 1 -C 6 alkyl, R is H or Ar: R 1 is H, CH 3 or Ar:
Claim 2
Dependent Claim
41 words
A compound of the formula ##STR7## where X is hydrogen, one or more of halogen, hydroxy, alkoxy having 1-3 carbon atoms, benzyloxy, or C 1 -C 6 alkyl, R is H or Ar: R 1 is H, CH 3 or Ar:
Claim 3
Dependent Claim
59 words
Ar is ##STR8## R 2 is C 1 -C 6 alkyl; n is 0 or 1 when R is Ar or 1 when R 1 is Ar; and m is 2-6, with the provision that both R and R 1 are not Ar at the same time and that at least one of R and R 1 is Ar.
Claim 4
Dependent Claim
59 words
Ar is ##STR8## R 2 is C 1 -C 6 alkyl; n is 0 or 1 when R is Ar or 1 when R 1 is Ar; and m is 2-6, with the provision that both R and R 1 are not Ar at the same time and that at least one of R and R 1 is Ar.
Claim 5
Dependent Claim
23 words
A compound of claim 1 wherein X is hydrogen, bromo, hydroxy, benzyloxy, methyl or dimethyl, R 2 is butyl and m is 3.
Claim 6
Dependent Claim
24 words
A compound of claim 1 selected from the group consisting of 2-(4-dibutylaminopropoxyphenyl)imidazo[1,2-a]pyridine; 2-(4-dibutylaminopropoxyphenyl)-8-methylimidazo [1,2-a]pyridine; 2-(4-dibutylaminopropoxyphenyl)-6-bromoimidazo [1,2-a]-pyridine; 2-(4-dibutylaminopropoxyphenyl)-7-methylimidazo-[1,2-a]pyridine; 2-(4-dibutylaminopropoxyphenyl)-3,8-dimethyl imidazo [1, 2-a]pyridine; 2-(4-dibutylaminopropoxyphenyl)-8-hydroxyimidazo[1,2-a]pyridine; and 2-(4-dibutylaminopropoxyphenyl)-8-benzoyloxyimidazo[1,2-a]pyridine.
Claim 7
Dependent Claim
17 words
A compound of claim 1 selected from the group consisting of 2-(4-dibutylaminopropoxybenzoyl)-8-methylimidazo[1,2-a]-pyridine; 2-(4-dibutylaminopropoxybenzoyl)-5,7-dimethylimidazo[1,2-a]pyridine; 2-(4-dibutylaminopropoxybenzoyl)-7-methylimidazo[1,2-a]pyridine; 2-(4-dibutylaminopropoxybenzoyl)-8-benzyloxyimidazo[1,2-a]pyridine; and 2-(4-dibutylaminopropoxybenzoyl)-6-bromoimidazo[1,2-a]pyridine.
Claim 8
Dependent Claim
14 words
A compound of claim 1 selected from the group consisting of 3-(4-dibutylaminopropoxybenzoyl)-8-methylimidazo[1,2-a]-pyridine and 3-(4-dibutylaminopropoxybenzoyl)-6-bromoimidazo[1,2-a]pyridine.
References Cited (Backward Citations)
GB1058258A
Cited
EP0068378A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-22 | 1991-08-24 | 1992-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-22 | 1995-08-24 | 1996-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-22 | 1999-08-24 | 2000-02-23 | $7700.00 | Window Closed / Lapsed |