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US4824938A
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Water-soluble dry solid containing proteinaceous bioactive substance
Assignee: Hayashibara Seibutsu Kagaku Kenkyujo KK
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Filing: 1987-08-31
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Granted: 1989-04-25
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Expires: 2007-08-31
Abstract
Abstract Proteinaceous bioactive substances (including lymphokine and peptide hormone) in dry solid are extremely stabilized by the presence of the specific polysaccharide mainly composed of repeating maltotriose units. Pullulan, elsinan, and their partial hydrolysates are feasible as the polysaccharide. The weight ratio of the polysaccharide to the substance which effectively stabilizes the latter substance is at least 0.5 on the basis of dry solids. The dry solid is advantageously usable as a test reagent, injection, granule, tablet, suppository or ointment.
Inventors
- 👤 Shunsaku Koyama
- 👤 Toshio Miyake
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 09:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K47/00; A61K47/30; A61K47/36; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/485; C07K14/505; C07K14/52; C07K14/525; C07K14/555; C07K14/575; C07K14/59; C07K14/61
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
33 words
A water-soluble dry solid composition, comprising: one part by weight of a proteinaceous bioactive substance in admixture with at least 0.5 parts by weight of a polysaccharide mainly composed of repeating maltotriose units.
Claim 2
Dependent Claim
33 words
A water-soluble dry solid composition, comprising: one part by weight of a proteinaceous bioactive substance in admixture with at least 0.5 parts by weight of a polysaccharide mainly composed of repeating maltotriose units.
Claim 3
Dependent Claim
25 words
The composition in accordance with claim 1, wherein the proteinaceous bioactive substance is a member selected from the group consisting of lymphokine and peptide hormone.
Claim 4
Dependent Claim
27 words
The composition in accordance with claim 1, wherein the polysaccharide is a member selected from the group consisting of pullulan, elsinan, their partial hydrolysates, and mixtures thereof.
Claim 5
Dependent Claim
21 words
The composition in accordance with claim 1, wherein the molecular weight of the polysaccharide is within the range of 10,000-10,000,000 daltons.
Claim 6
Dependent Claim
28 words
The composition in accordance with claim 1, containing between 0.5 and 10,000 parts by weight of said polysaccharide to one part by weight of said proteinaceous bioactive substance.
Claim 7
Independent Claim
89 words
A method for making a water-soluble dry solid composition containing a mixture of one part by weight of a proteinaceous bioactive substance along with at least 0.5 parts by weight of a polysaccharide mainly composed of repeating maltotriose units, said method comprising: providing an aqueous solution containing one part by weight of said proteinaceous bioactive substance in admixture with at least 0.5 parts by weight of said polysaccharide; and drying the aqueous solution at a temperature below 30° C. and reduced pressure to produce said water-soluble dry solid composition.
Claim 8
Independent Claim
89 words
A method for making a water-soluble dry solid composition containing a mixture of one part by weight of a proteinaceous bioactive substance along with at least 0.5 parts by weight of a polysaccharide mainly composed of repeating maltotriose units, said method comprising: providing an aqueous solution containing one part by weight of said proteinaceous bioactive substance in admixture with at least 0.5 parts by weight of said polysaccharide; and drying the aqueous solution at a temperature below 30° C. and reduced pressure to produce said water-soluble dry solid composition.
Claim 9
Dependent Claim
25 words
The method in accordance with claim 6, wherein the proteinaceous bioactive substance is a member selected from the group consisting of lymphokine and peptide hormone.
Claim 10
Dependent Claim
27 words
The method in accordance with claim 6, wherein the polysaccharide is a member selected from the group consisting of pullulan, elsinan, their partial hydrolysates, and mixtures thereof.
Claim 11
Dependent Claim
21 words
The method in accordance with claim 6, wherein the molecular weight of the polysaccharide is within the range of 10,000-10,000,000 daltons.
Claim 12
Dependent Claim
15 words
The method in accordance with claim 6, wherein said drying step is effected by freeze-drying.
Claim 13
Dependent Claim
28 words
The method in accordance with claim 6, containing between 0.5 and 10,000 parts by weight of said polysaccharide to one part by weight of said proteinaceous bioactive substance.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-24 | 1992-10-24 | 1993-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-24 | 1996-10-24 | 1997-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-24 | 2000-10-24 | 2001-04-25 | $7700.00 | Window Closed / Lapsed |