US4821733A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Transdermal detection system
Assignee: Dermal Systems International Inc
•
Filing: 1987-08-18
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Granted: 1989-04-18
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Expires: 2007-08-18
Abstract
Abstract A transdermal detection system for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion comprises detector means and attachment means. The detector means includes at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the skin surface of the subject to produce a detectable signal, and a barrier means for substantially preventing migration of the detector chemical into the skin surface of the subject. The attachment means maintains the detector means adjacent the surface of the skin of the subject.
Inventors
- 👤 Carl C. Peck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:54
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/14517; A61B5/14521; A61B5/14532; C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; C12Q1/54; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/5302; C12Q2326/00; C12Q2326/10; C12Q2326/12
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
99 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 2
Independent Claim
99 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 3
Dependent Claim
40 words
An apparatus as defined by claim 1, wherein the detector means is capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce an electrically detectable signal.
Claim 4
Dependent Claim
48 words
An apparatus as defined by claim 2, wherein the detector means is capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce an electrically detectable change in an ion concentration in the detector means.
Claim 5
Dependent Claim
47 words
An apparatus as defined by claim 1, wherein the detector means further comprises a carrier substantially saturated with the detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject.
Claim 6
Dependent Claim
15 words
An apparatus as defined by claim 4, wherein the carrier comprises a porous support member.
Claim 7
Dependent Claim
29 words
An apparatus as defined by claim 5, wherein the carrier comprises a microporous membrane containing covalent functional groups capable of covalently binding with the detector chemical contained in solution.
Claim 8
Dependent Claim
18 words
An apparatus as defined by claim 1, wherein the barrier means comprises a permeable or a semipermeable membrane.
Claim 9
Dependent Claim
16 words
An apparatus as defined by claim 1, wherein the barrier means comprises a layer of gel.
Claim 10
Dependent Claim
30 words
An apparatus as defined by claim 1, wherein the barrier means comprises a microporous membrane containing covalent functional groups capable of covalently binding with the detector chemical contained in solution.
Claim 11
Dependent Claim
29 words
An apparatus as defined by claim 1, wherein the detector chemical is selected from chemical reagents, antibodies, enzymes and biological receptors and is contained in solution in a solvent.
Claim 12
Dependent Claim
48 words
An apparatus as defined by claim 1, wherein the detector means includes a mixture of detector chemicals contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal.
Claim 13
Dependent Claim
30 words
An apparatus as defined by claim 1, wherein the attachment means includes an adhesive area for adhesively maintaining the detector means adjacent the surface of the skin of the subject.
Claim 14
Dependent Claim
33 words
An apparatus as defined by claim 1, further comprising an impermeable cover means covering the surfaces of the detector means which are not positionable adjacent the surface of the skin of the subject.
Claim 15
Dependent Claim
65 words
An apparatus as defined by claim 1, further including a removable impermeable cover means covering the surface of the detector means which is positionable adjacent the surface of the skin of the subject, which removable cover means is adapted to be removed from the apparatus prior to use for the detection of a target substance migrating to the surface of the skin of the subject.
Claim 16
Dependent Claim
33 words
An apparatus as defined by claim 1, further including a signalling means capable of converting the detectable signal produced by the detector means into a form which is observable by the human eye.
Claim 17
Dependent Claim
14 words
An apparatus as defined by claim 15, wherein the signalling means includes microprocessing means.
Claim 18
Independent Claim
100 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce an optically detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 19
Independent Claim
100 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce an optically detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 20
Dependent Claim
45 words
An apparatus as defined by claim 17, wherein the detector means is capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a visually detectable color change in the detector means.
Claim 21
Independent Claim
127 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal, said detector chemical being selected from chemical reagents, antibodies, enzymes and biological receptors contained in solution in a solvent and including an oxidase in solution in a solvent, and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 22
Independent Claim
127 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal, said detector chemical being selected from chemical reagents, antibodies, enzymes and biological receptors contained in solution in a solvent and including an oxidase in solution in a solvent, and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 23
Dependent Claim
18 words
An apparatus as defined by claim 19, wherein the oxidase is selected from alcohol oxidases and glucose oxidases.
Claim 24
Independent Claim
112 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical including a mixture of an oxidase and a peroxidase contained in solution in an aqueous solvent and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 25
Independent Claim
112 words
An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) at least one detector chemical including a mixture of an oxidase and a peroxidase contained in solution in an aqueous solvent and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 26
Dependent Claim
18 words
An apparatus as defined by claim 21, wherein the oxidase is selected from alcohol oxidases and glucose oxidases.
Claim 27
Dependent Claim
13 words
An apparatus as defined by claim 21, wherein the peroxidase comprises horseradish peroxidase.
Claim 28
Independent Claim
101 words
An apparatus for the detection of ethanol which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) detector chemicals comprising an alcohol oxidase, horseradish peroxidase and tetramethylbenzidine contained in solution and capable of chemically reacting with the ethanol as the ethanol migrates to the surface of the skin of the subject to produce a detectable color change and (b) a barrier means for substantially preventing migration of said detector chemicals into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 29
Independent Claim
101 words
An apparatus for the detection of ethanol which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) detector chemicals comprising an alcohol oxidase, horseradish peroxidase and tetramethylbenzidine contained in solution and capable of chemically reacting with the ethanol as the ethanol migrates to the surface of the skin of the subject to produce a detectable color change and (b) a barrier means for substantially preventing migration of said detector chemicals into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 30
Independent Claim
100 words
An apparatus for the detection of glucose which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) detector chemicals comprising glucose oxidase, horseradish peroxidase and tetramethylbenzidine contained in solution and capable of chemically reacting with the glucose as the glucose migrates to the surface of the skin of the subject to produce a detectable color change and (b) a barrier means for substantially preventing migration of said detector chemicals into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 31
Independent Claim
100 words
An apparatus for the detection of glucose which migrates to the surface of the skin of a subject by diffusion, comprising detector means including (a) detector chemicals comprising glucose oxidase, horseradish peroxidase and tetramethylbenzidine contained in solution and capable of chemically reacting with the glucose as the glucose migrates to the surface of the skin of the subject to produce a detectable color change and (b) a barrier means for substantially preventing migration of said detector chemicals into the skin of the subject; and attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
Claim 32
Independent Claim
96 words
A method for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising maintaining a detector means adjacent the surface of the skin of the subject, the detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal, and (b) a barrier means for substantially preventing migration of said detector chemical into the skin of the subject.
Claim 33
Independent Claim
96 words
A method for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising maintaining a detector means adjacent the surface of the skin of the subject, the detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal, and (b) a barrier means for substantially preventing migration of said detector chemical into the skin of the subject.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |