US4820506A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Salivary stimulant
Assignee: RESEARCH FOUNDATION A NONPROFIT ORGANIZATION OF NEW YORK
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Filing: 1987-05-01
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Granted: 1989-04-11
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Expires: 2007-05-01
Abstract
Abstract An aqueous liquid for promoting the production of human saliva in situ comprises: (a) about 2 to 3 wgt percent organic acidulent such as citric, malic, or ascorbic acid; (b) about 0.5 to 2.5 wgt percent of a natural, food-grade sweetener such as fructose or 0.05 to 0.5 wgt percent of a synthetic sweetener such as aspartame or saccharin; and (c) a saturated calcium phosphate solution. The preferred form of the aqueous liquid is a metered, hand-actuated, aerosol spray of about 0.15 ml. per actuation. By employing the aqueous liquid of the invention the production of saliva is tripled, thus alleviating the many symptoms of xerostomia no matter what its cause.
Inventors
- 👤 Israel Kleinberg
- 👤 Leo M. Sreebny
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:00
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/42
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
82 words
A composition for promoting the production of human saliva consisting essentially of an aqueous liquid solution of water having dissolved therein: (a) from about 2 to about 3 wgt percent food-grade organic acidulent; (b) a food-grade sweetener benign to stomic microflora selected from the group consisting of a sugar, a synthetic sweetener, and a reduced, sugar-related compound, and (c) a saturated calcium phosphate solution, whereby the production of human saliva is promoted in situ without corrosion, infection, or dissolution of human teeth.
Claim 2
Dependent Claim
82 words
A composition for promoting the production of human saliva consisting essentially of an aqueous liquid solution of water having dissolved therein: (a) from about 2 to about 3 wgt percent food-grade organic acidulent; (b) a food-grade sweetener benign to stomic microflora selected from the group consisting of a sugar, a synthetic sweetener, and a reduced, sugar-related compound, and (c) a saturated calcium phosphate solution, whereby the production of human saliva is promoted in situ without corrosion, infection, or dissolution of human teeth.
Claim 3
Dependent Claim
25 words
The composition of claim 1, wherein the acidulent is selected from the group consisting of citric, malic, ascorbic, tartaric, fumaric, succinic, lactic, and adipic acids.
Claim 4
Dependent Claim
41 words
The composition of claim 1, wherein the sweetener is selected from the group consisting of fructose, glucose, dextrose, corn sugar, sucrose, lactose, maltose, xylose, aspartylphenylalanine ester, saccharin, aspartyldiaminoalkane, aspartylaminoalkyl carboxylic ester, trifluoroacetylaspartylanilide, aspartylalanyltripeptide, sorbitol, xylitol, mannitol, maltilol, dexitol, and hydrolyzed starch.
Claim 5
Dependent Claim
16 words
The composition of claim 3, wherein the sweetener is saccharin to which sorbitol has been added.
Claim 6
Dependent Claim
17 words
The composition of claim 3, wherein the sweetener is aspartylphenylalanine ester to which sorbitol has been added.
Claim 7
Dependent Claim
16 words
The composition of claim 3, wherein the sweetener is saccharin to which mannitol has been added.
Claim 8
Dependent Claim
17 words
The composition of claim 3, wherein the sweetener is aspartylphenylalanine ester to which mannitol has been added.
Claim 9
Dependent Claim
26 words
The composition of claim 1, wherein the calcium phosphate solution is selected from the group consisting of monocalcium, dicalcium, and tricalcium, and octacalcium phosphate, and hydroxyapatite.
Claim 10
Dependent Claim
15 words
The composition of claim 1, wherein the pH ranges from about 3 to about 4.
Claim 11
Dependent Claim
90 words
A composition for promoting the production of human saliva consisting essentially of an aqueous liquid solution of water in the form of an atomized droplet spray, having dissolved therein: (a) from about 2 to about 3 wgt percent food-grade organic acidulent; (b) a food-grade sweetener benign to stomic microflora selected from the group consisting of a sugar, a synthetic sweetener, and a reduced, sugar-related compound, and (c) a saturated calcium phosphate solution, whereby the production of human saliva is promoted in situ without corrosion, infection, or dissolution of human teeth.
Claim 12
Dependent Claim
90 words
A composition for promoting the production of human saliva consisting essentially of an aqueous liquid solution of water in the form of an atomized droplet spray, having dissolved therein: (a) from about 2 to about 3 wgt percent food-grade organic acidulent; (b) a food-grade sweetener benign to stomic microflora selected from the group consisting of a sugar, a synthetic sweetener, and a reduced, sugar-related compound, and (c) a saturated calcium phosphate solution, whereby the production of human saliva is promoted in situ without corrosion, infection, or dissolution of human teeth.
Claim 13
Dependent Claim
19 words
The composition of claim 10, wherein the pH of the droplet spray ranges from about 3 to about 4.
Claim 14
Dependent Claim
28 words
The droplet spray of claim 10, wherein the spray is atomized and metered to deliver a dose of from about 0.1 to about 0.4 ml liquid per actuation.
Claim 15
Dependent Claim
16 words
The droplet spray of claim 12, wherein the dose is about 0.15 ml liquid per actuation.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-10 | 1992-10-10 | 1993-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-10 | 1996-10-10 | 1997-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-10 | 2000-10-10 | 2001-04-11 | $7700.00 | Window Closed / Lapsed |