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US4818769A
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Method of controlling stress-related disease in livestock by administration of human IL-2
Assignee: Novartis Vaccines and Diagnostics Inc
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Filing: 1986-04-25
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Granted: 1989-04-04
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Expires: 2006-04-25
Abstract
Abstract Disclosed herein is a method of mitigating stress-related syndromes in livestock, such as shipping fever in cattle, by administration of human IL-2.
Inventors
- 👤 Jack H. Nunberg
- 👤 Michael Doyle
- 👤 Arthur Newell
- 👤 Thomas White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 22:35
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61K2039/555; A61K2039/55511; A61K2039/55522; A61K2039/55527; A61K2039/55533; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
103 words
A method of diminishing the incidence of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of hIL-2 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole hIL-2.
Claim 2
Independent Claim
103 words
A method of diminishing the incidence of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of hIL-2 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole hIL-2.
Claim 3
Independent Claim
106 words
A method of diminishing the incidence of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of des-alanyl-rIL-2 ser125 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole des-alanyl-rIL-2 ser125 .
Claim 4
Independent Claim
106 words
A method of diminishing the incidence of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of des-alanyl-rIL-2 ser125 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole des-alanyl-rIL-2 ser125 .
Claim 5
Independent Claim
102 words
A method of ameliorating the symptoms of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of hIL-2 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole hIL-2.
Claim 6
Independent Claim
102 words
A method of ameliorating the symptoms of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of hIL-2 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole hIL-2.
Claim 7
Independent Claim
106 words
A method of ameliorating the symptoms of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of des-analy-rIL-2 ser125 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole des-alanyl-rIL-2 ser125 .
Claim 8
Independent Claim
106 words
A method of ameliorating the symptoms of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of des-analy-rIL-2 ser125 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole des-alanyl-rIL-2 ser125 .
Claim 9
Independent Claim
102 words
A method of shortening the duration of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of hIL-2 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole hIL-2.
Claim 10
Independent Claim
102 words
A method of shortening the duration of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of hIL-2 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole hIL-2.
Claim 11
Independent Claim
106 words
A method of shortening the duration of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of des-alanyl-rIL-2 ser125 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole des-alanyl-rIL-2 ser125 .
Claim 12
Independent Claim
106 words
A method of shortening the duration of shipping fever in livestock which comprises administering to subject livestock an amount of a water soluble form of des-alanyl-rIL-2 ser125 in the range of above about 10 3 and below about 10 6 u/kg/day over a period of from about 14 to 30 days, wherein the water soluble form of hIL-2 is hIL-2 covalently bonded through one or two amino acids via a coupling agent to polyethylene glycol having a molecular weight in the range of from about 500 to 200,000, and wherein no more than about 50 moles of polyethylene glycol are employed per mole des-alanyl-rIL-2 ser125 .
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