Patent FR1063100A successfully refreshed from Google Patents.
Patent US4818519A successfully refreshed from Google Patents.
US4818519A
Expired / Lapsed
US
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Method and composition for prevention of plaque formation and plaque dependent diseases
Assignee: Micropure Inc
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Filing: 1987-08-24
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Granted: 1989-04-04
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Expires: 2007-08-24
Abstract
Abstract The use of stabilized chlorine dioxide or chlorine dioxide in aqueous solution as a composition to reduce or prevent plaque formation and treatment of oral diseases ecologically plaque dependent, such as gingivitis and periodontitis, is disclosed. Preferred concentrations are in the range of 0.005% to 0.2% and the chlorine dioxide may be in the form of a rinse, a wash, a soak or a dentifrice.
Inventors
- 👤 Perry A. Ratcliff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 21:59
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0078; A; A61; A61K; A61K33/00; A61K33/20; A61K8/00; A61K8/18; A61K8/19; A61K8/22; A61Q; A61Q11/00; A61Q11/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
116 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby creating a higher oxygen tension in the saliva present in the oral cavity by decreasing the anaerobic bacterial population and increasing the aerobic bacterial population within the oral cavity, converting living tissues adjacent oxygenated saliva from anaerobic into aerobic glycolysis, increasing the number of adenosinetrephosphate molecules said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of creating, converting and increasing.
Claim 2
Independent Claim
116 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby creating a higher oxygen tension in the saliva present in the oral cavity by decreasing the anaerobic bacterial population and increasing the aerobic bacterial population within the oral cavity, converting living tissues adjacent oxygenated saliva from anaerobic into aerobic glycolysis, increasing the number of adenosinetrephosphate molecules said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of creating, converting and increasing.
Claim 3
Independent Claim
120 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population within the oral cavity, increasing the aerobic bacterial population within the oral cavity, retarding the immune reaction within the oral cavity and concomitant lymphocyte cloning, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing, retarding and hindering.
Claim 4
Independent Claim
120 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population within the oral cavity, increasing the aerobic bacterial population within the oral cavity, retarding the immune reaction within the oral cavity and concomitant lymphocyte cloning, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing, retarding and hindering.
Claim 5
Independent Claim
103 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population, increasing the aerobic bacterial population within the oral cavity, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing and hindering.
Claim 6
Independent Claim
103 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population, increasing the aerobic bacterial population within the oral cavity, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing and hindering.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-04-03 | 1992-10-03 | 1993-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-03 | 1996-10-03 | 1997-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-03 | 2000-10-03 | 2001-04-04 | $7700.00 | Window Closed / Lapsed |