US4818519A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and composition for prevention of plaque formation and plaque dependent diseases
Assignee: Micropure Inc
•
Filing: 1987-08-24
•
Granted: 1989-04-04
•
Expires: 2007-08-24
Abstract
Abstract The use of stabilized chlorine dioxide or chlorine dioxide in aqueous solution as a composition to reduce or prevent plaque formation and treatment of oral diseases ecologically plaque dependent, such as gingivitis and periodontitis, is disclosed. Preferred concentrations are in the range of 0.005% to 0.2% and the chlorine dioxide may be in the form of a rinse, a wash, a soak or a dentifrice.
Inventors
- 👤 Perry A. Ratcliff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 07:52
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0078; A; A61; A61K; A61K33/00; A61K33/20; A61K8/00; A61K8/18; A61K8/19; A61K8/22; A61Q; A61Q11/00; A61Q11/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
116 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby creating a higher oxygen tension in the saliva present in the oral cavity by decreasing the anaerobic bacterial population and increasing the aerobic bacterial population within the oral cavity, converting living tissues adjacent oxygenated saliva from anaerobic into aerobic glycolysis, increasing the number of adenosinetrephosphate molecules said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of creating, converting and increasing.
Claim 2
Independent Claim
116 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby creating a higher oxygen tension in the saliva present in the oral cavity by decreasing the anaerobic bacterial population and increasing the aerobic bacterial population within the oral cavity, converting living tissues adjacent oxygenated saliva from anaerobic into aerobic glycolysis, increasing the number of adenosinetrephosphate molecules said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of creating, converting and increasing.
Claim 3
Independent Claim
120 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population within the oral cavity, increasing the aerobic bacterial population within the oral cavity, retarding the immune reaction within the oral cavity and concomitant lymphocyte cloning, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing, retarding and hindering.
Claim 4
Independent Claim
120 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population within the oral cavity, increasing the aerobic bacterial population within the oral cavity, retarding the immune reaction within the oral cavity and concomitant lymphocyte cloning, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing, retarding and hindering.
Claim 5
Independent Claim
103 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population, increasing the aerobic bacterial population within the oral cavity, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing and hindering.
Claim 6
Independent Claim
103 words
A method for preventing periodontitis in the oral cavity, said method comprising the steps of applying within the oral cavity, for a period of ten seconds, a stabilized aqueous solution of chlorine dioxide, having an effective concentration in the range of 0.005% to 0.2%, and thereby decreasing the anaerobic bacterial population, increasing the aerobic bacterial population within the oral cavity, hindering the compliment cascade normally resulting from lymphocyte cloning to reduce inflammation and bone loss within the oral cavity, said stabilized chlorine dioxide in aqueous solution being an agent effective to at least assist in accomplishing said steps of decreasing, increasing and hindering.
References Cited (Backward Citations)
US2482958A
Cited
US2546258A
Cited
US2451897A
Cited
US2711363A
Cited
US2871097A
Cited
US3322497A
Cited
US3147124A
Cited
US3084995A
Cited
US3591515A
Cited
US3593494A
Cited
US3585147A
Cited
US3754079A
Cited
US3828097A
Cited
US4104190A
Cited
US4330531A
Cited
US4250159A
Cited
US4250144A
Cited
US4247531A
Cited
US4292292A
Cited
US4396592A
Cited
US4362707A
Cited
US4381290A
Cited
US4414193A
Cited
US4689215A
Cited
US4696811A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-03 | 1992-10-03 | 1993-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-03 | 1996-10-03 | 1997-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-03 | 2000-10-03 | 2001-04-04 | $7700.00 | Window Closed / Lapsed |