Patent US4814077A successfully refreshed from Google Patents.
US4814077A
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Lipoprotein adsorbent and apparatus for removing lipoproteins using the same
Assignee: Kanegafuchi Chemical Industry Co Ltd
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Filing: 1987-02-09
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Granted: 1989-03-21
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Expires: 2007-02-09
Abstract
Abstract An adsorbent for lipoproteins which is a water-insoluble matrix having, on at least a part of the surface thereof, a group of the formula -NR1R2 wherein R1 is hydrogen, methyl group or ethyl group; R2 is an atomic group having an aromatic ring satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula R2H is from 0 to 3.2 and an apparatus for removing lipoproteins using the above adsorbent. The lipoprotein adsorbent has such advantages as a low cost, a good stability and a sufficient adsorption selectivity for adsorbing LDL and VLDL in a fluid containing lipoproteins.
Inventors
- 👤 Shigeo Furuyoshi
- 👤 Nobutaka Tani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:40
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3253; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B01J20/3255; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0456; A61M2202/046
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
96 words
An adsorbent for lipoprotein which is a water-insoluble matrix, in which a group of the formula: --NR.sup.1 R.sup.2 wherein R 1 is a hydrogen atom, methyl group or ethyl group; and R 2 is a substituent with an aromatic ring and satisfying the condition that the value of log P, in which P is a partition coefficeint for a compound of the formula R 2 H in a water-octanal system defined by the formula ##EQU4## is from 0 to 3.2 and is immobilized onto at least a part of the surface thereof by a covalent bond.
Claim 2
Dependent Claim
96 words
An adsorbent for lipoprotein which is a water-insoluble matrix, in which a group of the formula: --NR.sup.1 R.sup.2 wherein R 1 is a hydrogen atom, methyl group or ethyl group; and R 2 is a substituent with an aromatic ring and satisfying the condition that the value of log P, in which P is a partition coefficeint for a compound of the formula R 2 H in a water-octanal system defined by the formula ##EQU4## is from 0 to 3.2 and is immobilized onto at least a part of the surface thereof by a covalent bond.
Claim 3
Dependent Claim
13 words
The adsorbent of claim 1, wherein said water-insoluble matrix has a porous structure.
Claim 4
Dependent Claim
30 words
The adsorbent of claim 2, wherein said water-insoluble matrix has a pore size which excludes globular proteins having a molecular weight greater than between 1×10 6 to 1×10 8 .
Claim 5
Dependent Claim
27 words
An absorbent for lipoprotein according to claim 1, wherein the compound of the formula --NR 1 R 2 is anilino, an anilino derivitive, or a mixture thereof.
Claim 6
Dependent Claim
28 words
An absorbent for lipoprotein according to claim 1, wherein the compound of the formula --NR 1 R 2 is a benzylamino, a benzylamino derivative, or a mixture thereof.
Claim 7
Independent Claim
144 words
An apparatus for removing lipoprotein from body fluids comprising a container having at least one fluid inlet, at least one fluid outlet, filters at each inlet and outlet, and packed with a water-insoluble matrix, said filters being permeable to said body fluids and impermeable to said water-insoluble matrix, said water-insoluble matrix comprising an absorbent for lipoproteins in which a group of the formula: --NR.sup.1 R.sup.2 wherein R 1 is selected from the group consisting of hydrogen, methyl and ethyl, and R 2 is a substituent with an aromatic ring and satisfies the condition that the value of log P, wherein P is the partition coefficient for a compound of the formula R 2 H in a water-octanol system defined by the formula: ##EQU5## is from 0 to 3.2 and is immobilized onto at least a part of the surface thereof by a covalent bond.
Claim 8
Independent Claim
144 words
An apparatus for removing lipoprotein from body fluids comprising a container having at least one fluid inlet, at least one fluid outlet, filters at each inlet and outlet, and packed with a water-insoluble matrix, said filters being permeable to said body fluids and impermeable to said water-insoluble matrix, said water-insoluble matrix comprising an absorbent for lipoproteins in which a group of the formula: --NR.sup.1 R.sup.2 wherein R 1 is selected from the group consisting of hydrogen, methyl and ethyl, and R 2 is a substituent with an aromatic ring and satisfies the condition that the value of log P, wherein P is the partition coefficient for a compound of the formula R 2 H in a water-octanol system defined by the formula: ##EQU5## is from 0 to 3.2 and is immobilized onto at least a part of the surface thereof by a covalent bond.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |