US4409105A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dried, sterilized, gamma-globulin-fixed column and a process for preparing the same
Assignee: Asahi Kasei Corp
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Filing: 1981-11-20
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Granted: 1983-10-11
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Expires: 2001-11-20
Abstract
Abstract A dried, sterilized column containing a carrier-fixed gamma -globulin capable of specifically combining with various harmful substances found in blood of patients suffering from certain diseases and acting as an antibody. The gamma -globulin fixed column according to the present invention has a prolonged storage stability, and an excellent activity and safety even after the storage for a prolonged period of time as compared with unsterilized columns. Therefore, the gamma -globulin fixed column according to the present invention may be advantageously used for medical instrument applications.
Inventors
- 👤 Hiroshi Hayashi
- 👤 Takao Kiyota
- 👤 Mitsuru Shibukawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 04:17
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; A61K; A61K39/00; A61K39/395; A61K39/44; A61L; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L2103/00; A61L2103/05; Y; Y10; Y10S; Y10S530/00; Y10S530/868
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
54 words
A γ-globulin fixed column comprising a vessel, a pair of spaced filter screens, an inlet, an outlet and carrier resin having γ-globulin borne thereby and fixed thereto and packed in a dried and sterilized state into the vessel between the screens, the sterilization having been effected with ethylene oxide gas or propylene oxide gas.
Claim 2
Dependent Claim
54 words
A γ-globulin fixed column comprising a vessel, a pair of spaced filter screens, an inlet, an outlet and carrier resin having γ-globulin borne thereby and fixed thereto and packed in a dried and sterilized state into the vessel between the screens, the sterilization having been effected with ethylene oxide gas or propylene oxide gas.
Claim 3
Dependent Claim
35 words
A column according to claim 1, wherein said borne γ-globulin is at least one member selected from the group consisting of anti-human-α-fetoprotein-γ-globulin, anti-human-ferritin-γ-globulin, anti-B type hepatitis virus antigen γ-globulin, anti-anti-nuclear antibody-γ-globulin and anti-human-acetylcholine receptor antibody-γ-globulin.
Claim 4
Dependent Claim
15 words
A column according to claim 1, wherein said carrier is of an agarose type resin.
Claim 5
Dependent Claim
16 words
A column according to claim 1, wherein said carrier is of a polyvinyl alcohol type resin.
Claim 6
Dependent Claim
36 words
A process for preparing a dried, sterilized γ-globulin-fixed column which comprises subjecting carrier resin having γ-globulin borne thereby and fixed thereto to drying treatment and then to sterilization with ethylene oxide gas or propylene oxide gas.
Claim 7
Dependent Claim
36 words
A process for preparing a dried, sterilized γ-globulin-fixed column which comprises subjecting carrier resin having γ-globulin borne thereby and fixed thereto to drying treatment and then to sterilization with ethylene oxide gas or propylene oxide gas.
Claim 8
Dependent Claim
12 words
A process according to claim 5, wherein said drying treatment is lyophilization.
Claim 9
Dependent Claim
36 words
A process according to claim 6, wherein prior to the lyophilization said γ-globulin fixed column is equilibrated with a 1-20% aqueous solution of a sugar selected from the group consisting of mannose, lactose, sucrose and glucose.
Claim 10
Dependent Claim
20 words
A process according to claim 7, wherein said aqueous solution of a sugar is a 5-15% aqueous solution of glucose.
Claim 11
Dependent Claim
39 words
A process according to any of claims 5 to 8, wherein said borne γ-globulin is at least one member selected from the group consisting of anti-human-α-fetoprotein-γ-globulin, anti-human-ferritin-γ-globulin, anti-B type hepatitis virus antigen γ-globulin, anti-anti-nuclear antibody-γ-globulin and anti-human-acetylcholine receptor antibody-γ-globulin.
Claim 12
Dependent Claim
15 words
A process according to claim 5, wherein said carrier is of an agarose type resin.
Claim 13
Dependent Claim
16 words
A process according to claim 5, wherein said carrier is of a polyvinyl alcohol type resin.
Claim 14
Dependent Claim
15 words
A process according to claim 5, wherein said sterilization is effected using ethylene oxide gas.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-10 | 1987-04-11 | 1987-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-10 | 1991-04-11 | 1991-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-10 | 1995-04-11 | 1995-10-11 | $7700.00 | Window Closed / Lapsed |