Imide derivatives and their use in the treatment psychosis

Claim 1

A compound of the formula: ##STR187## wherein A is a carbonyl group or a sulfonyl group; B is either one of the following formulas: ##STR188## wherein R 1 and R 2 are each a hydrogen atom, or either one of R 1 and R 2 is a hydrogen atom and the other is a hydroxyl group, a lower alkyl group or a lower alkanoyloxy group, or R 1 and R 2 are combined together to represent an oxo group, E is a methylene group, an ethylene group or an oxygen atom and a full line accompanying a broken line ( ) indicates a single bond or a double bond, ##STR189## wherein F is a methylene group or an ethylene group and R 1 , R 2 and a full line accompanying a broken line ( ) are each as defined above, ##STR190## wherein R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each a hydrogen atom or a lower alkyl group and R 1 , R 2 and a full line accompanying a broken line ( ) are each as defined above, ##STR191## wherein R 9 and R 10 are each a lower alkyl group, or B is a 1,2-phenylene group when A represents a sulfonyl group; W is a lower alkylene group, a lower alkenylene group, a lower alkynylene group or a lower alkylene group substituted with hydroxyl; and G is a benzoisothiazolyl group, a benzoiosthiazolyl substituted with a member selected from the group consisting of lower alkyl, lower alkoxy, halogen, and halogenated lower alkyl, or a group of the formula: ##STR192## wherein Y is an oxygen atom, a carbonyl group, a methylene group, a group of the formula: ##STR193## wherein m is an integer of 0, 1 or 2, a group of the formula: ##STR194## wherein R 13 is a hydrogen atom, a lower alkyl group or a lower alkanoyl group or a group of the formula: ##STR195## and Z is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, or a pharmaceutically acceptable salt thereof.