US4562255A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted bi-alicyclic imides
Assignee: Wyeth LLC
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Filing: 1984-03-30
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Granted: 1985-12-31
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Expires: 2004-03-30
Abstract
Abstract There are disclosed compounds having the formula ##STR1## wherein X is a group selected from ##STR2## Y represents a single or double bond; R 1 is hydrogen or lower alkyl; n is an integer 2-4; n' is an integer 1-2; and R is 2-pyrimidinyl, 2-pyridinyl, 2-pyrazinyl, halo-substituted 2-pyrazinyl, 5-tetrazolyl, phenyl or phenyl substituted by halo, lower alkyl or lower alkoxy; and the pharmacologically acceptable salts thereof, which exhibit anti-hypertensive activity.
Inventors
- 👤 Meier E. Freed
- 👤 Magid A. Abou-Gharbia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:43
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/12
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
54 words
A compound having the formula ##STR7## wherein X is a group selected from ##STR8## Y represents a single or double bond; R 1 is hydrogen or lower alkyl; n is an integer 2-4; n' is an integer 1-2; and R is [2-pyrimidinyl, 2-pyridinyl,] 2-pyrazinyl, halo-substituted 2-pyrazinyl or 5-tetrazolyl; and the pharmacologically acceptable salts thereof.
Claim 2
Dependent Claim
54 words
A compound having the formula ##STR7## wherein X is a group selected from ##STR8## Y represents a single or double bond; R 1 is hydrogen or lower alkyl; n is an integer 2-4; n' is an integer 1-2; and R is [2-pyrimidinyl, 2-pyridinyl,] 2-pyrazinyl, halo-substituted 2-pyrazinyl or 5-tetrazolyl; and the pharmacologically acceptable salts thereof.
Claim 3
Dependent Claim
10 words
A compound of claim 1, having the name hexahydro-2-[4-[4-[2-chloropyrazinyl]-1-piperazinyl]butyl]-4,7-epoxy-1H-isoindole-1,3 (2H)-dione.
Claim 4
Dependent Claim
9 words
A compound of claim 1, having the name hexahydro-2-[4-[4-(2-pyrazinyl)-1-piperazinyl]butyl]-4,7-epoxy-1H-isoindole-1,3(2H)-dione.
Claim 5
Dependent Claim
9 words
A compound of claim 1 having the name hexahydro-2-[4-[4-(5-tetrazoyl)-1-piperazinyl]butyl]-4,7-epoxy-1H-isoindole-1,3(2H)-dione.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-30 | 1989-07-01 | 1989-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-30 | 1993-07-01 | 1993-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-30 | 1997-07-01 | 1997-12-31 | $7700.00 | Window Closed / Lapsed |