US4355031A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2,3-Dihydro-3-[4-(substituted)-1-piperazinyl]-1H-isoindol-1-ones
Assignee: Wyeth LLC
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Filing: 1981-05-11
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Granted: 1982-10-19
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Expires: 2001-05-11
Abstract
Abstract Pyrazinoisoindolone derivatives of the formula ##STR1## wherein R 1 is lower alkyl, phenyl, diphenylmethyl, pyridinyl, pyrimidinyl, pyrazinyl or pyrazinyl substituted with a lower alkyl, lower alkoxy or halo; and R 2 is hydrogen, lower alkyl or di(lower)alkylamino(lower)alkyl are useful as antihypertensive agents.
Inventors
- 👤 Christopher A. Demerson
- 👤 Ivo L. Jirkovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:50
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/50
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
34 words
A compound of formula I ##STR4## wherein R 1 is lower alkyl, phenyl, diphenylmethyl, or pyridinyl; and R 2 is hydrogen, lower alkyl or di(lower)alkylamino(lower) alkyl; or a therapeutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
34 words
A compound of formula I ##STR4## wherein R 1 is lower alkyl, phenyl, diphenylmethyl, or pyridinyl; and R 2 is hydrogen, lower alkyl or di(lower)alkylamino(lower) alkyl; or a therapeutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
23 words
The compound of claim 1 wherein R 1 is lower alkyl, phenyl, diphenylmethyl, 2-pyridinyl, 4-pyridinyl; or a therapeutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
32 words
The compound of claim 1 wherein R 1 is methyl, phenyl, diphenylmethyl, 2-pyridinyl, 4-pyridinyl; and R 2 is methyl, ethyl, 1-methylethyl, (N,N-dimethylamino)ethyl or (N,N-dimethylamino)propyl; or a therapeutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
28 words
The compound of claim 1 wherein R 1 is 2-pyridinyl or 4-pyridinyl and R 2 is lower alkyl or di(lower)alkylamino(lower)alkyl, or a therapeutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
6 words
2,3-Dihydro-3-(4-methyl-1-piperazinyl)-1H-isoindol-1-one, as claimed in claim 1.
Claim 7
Dependent Claim
6 words
2,3-Dihydro-3-[4-(4-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 8
Dependent Claim
6 words
2,3-Dihydro-3-[4-(diphenylmethyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 9
Dependent Claim
6 words
2,3-Dihydro-3-[4-(2-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 10
Dependent Claim
6 words
2,3-Dihydro-3-(4-phenyl-1-piperazinyl)-1H-isoindol-1-one, as claimed in claim 1.
Claim 11
Dependent Claim
6 words
2,3-Dihydro-2-(1-methylethyl)-3-[4-(2-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 12
Dependent Claim
6 words
2,3-Dihydro-2-[(N,N-dimethylamino)propyl]-3-[4-(2-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 13
Dependent Claim
6 words
2,3-Dihydro-2-[(N,N-dimethylamino)ethyl]-3-[4-(2-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 14
Dependent Claim
6 words
2,3-Dihydro-2-ethyl-3-[4-(2-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 15
Dependent Claim
6 words
2,3-Dihydro-2-methyl-3-[4-(2-pyridinyl)-1-piperazinyl]-1H-isoindol-1-one, as claimed in claim 1.
Claim 16
Dependent Claim
25 words
An antihypertensive pharmaceutical composition which comprises a compound of claim 1, or a therapeutically acceptable acid addition salt thereof, and a pharmaceutically acceptable carrier therefor.
Claim 17
Dependent Claim
33 words
A method of treating hypertension in a hypertensive mammal which comprises administering to said mammal an effective antihypertensive amount of a compound of claim 1 or a therapeutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
CH374068A
Cited
US3579524A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-18 | 1986-04-19 | 1986-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-18 | 1990-04-19 | 1990-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-18 | 1994-04-19 | 1994-10-19 | $7700.00 | Window Closed / Lapsed |