Patent US4808404A successfully refreshed from Google Patents.
US4808404A
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US
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Live vaccine for coccidiosis utilizing coccidial sporozoites
Assignee: Zoetis Products LLC
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Filing: 1988-01-11
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Granted: 1989-02-28
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Expires: 2008-01-11
Abstract
Abstract Methods and compositions are disclosed for vaccinating warm-blooded animals against coccidiosis utilizing suspensions of excysted coccidial sporozoites in physiologically balanced medium containing water-soluble polymeric stabilizers selected from gels, gelatins, polysaccharide gums, cellulose or cellulose derivatives which extend viability or storage, additional extension of viability in storage being attained when the suspensions are finely divided and the polymeric stabilizers are hardened to form microcapsules.
Inventors
- 👤 Balbir S. Bhogal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:58
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/002; A61K39/012; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/947
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
59 words
A composition for vaccinating warm-blooded animals against coccidiosis disease comprised of a suspension of live excysted coccidial sporozoites in aqueous medium, physiologically balanced with respect to isotonicity and pH, containing at least one water-soluble viscosity enhancing polymeric substance selected from hydrosols, gels, gelatins, cellulose, cellulose derivatives and polysaccharide gums in amount sufficient to significantly prolong viability of said sporozoites.
Claim 2
Dependent Claim
59 words
A composition for vaccinating warm-blooded animals against coccidiosis disease comprised of a suspension of live excysted coccidial sporozoites in aqueous medium, physiologically balanced with respect to isotonicity and pH, containing at least one water-soluble viscosity enhancing polymeric substance selected from hydrosols, gels, gelatins, cellulose, cellulose derivatives and polysaccharide gums in amount sufficient to significantly prolong viability of said sporozoites.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein the water-soluble polysaccharide gum is sodium alginate.
Claim 4
Dependent Claim
14 words
The composition of claim 1 wherein the sporozoites are of the species Eimeria tenella.
Claim 5
Dependent Claim
72 words
A composition for vaccinating warm-blooded animals against coccidiosis disease comprised of microcapsules containing internally, inside the microcapsule wall, a suspension of live excysted coccidial sporozoites, physiologically balanced with respect to isotonicity and pH containing at least one water-soluble viscosity enhancing polymeric substance selected from hydrosols, gels, gelatins, cellulose, cellulose derivatives and polysaccharide gums in amount sufficient to significantly prolong viability of said sporozoites and said microcapsule wall comprised of hardened polymeric substance.
Claim 6
Dependent Claim
72 words
A composition for vaccinating warm-blooded animals against coccidiosis disease comprised of microcapsules containing internally, inside the microcapsule wall, a suspension of live excysted coccidial sporozoites, physiologically balanced with respect to isotonicity and pH containing at least one water-soluble viscosity enhancing polymeric substance selected from hydrosols, gels, gelatins, cellulose, cellulose derivatives and polysaccharide gums in amount sufficient to significantly prolong viability of said sporozoites and said microcapsule wall comprised of hardened polymeric substance.
Claim 7
Dependent Claim
20 words
The composition of claim 4 wherein the water-soluble polysaccharide gum is sodium alginate and the microcapsule wall is calcium alginate.
Claim 8
Dependent Claim
14 words
The composition of claim 4 wherein the sporozoites are of the species Eimeria tenella.
Claim 9
Dependent Claim
37 words
A composition comprised of a suspension of excysted coccidia sporozoites, physiologically balanced with rspect to isotonicity and pH, containing sodium alginate in solution, said composition having a viscosity in the range of 100-400 centipoises at 25° C.
Claim 10
Dependent Claim
37 words
A composition comprised of a suspension of excysted coccidia sporozoites, physiologically balanced with rspect to isotonicity and pH, containing sodium alginate in solution, said composition having a viscosity in the range of 100-400 centipoises at 25° C.
Claim 11
Dependent Claim
13 words
The composition of claim 7 wherein the species of sporozoites is Eimeria tenella.
Claim 12
Independent Claim
60 words
A method of vaccinating warm-blooded animals against coccidiosis disease by administering to said animal a composition comprised of a suspension of live excysted coccidial sporozoites, physiologically balanced with respect to isotonicity and pH containing at least one water-soluble viscosity enhancing polymeric substance selected from hydrosols, gels, gelatins and polysaccharide gums in amount sufficient to significantly prolong viability of said sporozoites.
Claim 13
Independent Claim
60 words
A method of vaccinating warm-blooded animals against coccidiosis disease by administering to said animal a composition comprised of a suspension of live excysted coccidial sporozoites, physiologically balanced with respect to isotonicity and pH containing at least one water-soluble viscosity enhancing polymeric substance selected from hydrosols, gels, gelatins and polysaccharide gums in amount sufficient to significantly prolong viability of said sporozoites.
Claim 14
Dependent Claim
13 words
The method of claim 9 wherein the water-soluble polysaccharide gum is sodium alginate.
Claim 15
Dependent Claim
11 words
The method of claim 9 wherein the animal is a chicken.
Claim 16
Dependent Claim
23 words
The method of claim 9 wherein the animal is a chicken and the composition is administered subcutaneously in the back of the neck.
Claim 17
Independent Claim
87 words
A method of vaccinating warm-blooded animals against coccidiosis disease by administering to said animal a composition comprised of microcapsules containing internally, inside the microcapsule wall, a suspension of live excysted coccidial sporozoites, physiologically balanced with respect to isotonicity and pH and containing said suspension containing at least one water-soluble viscosity enhancing polymeric substances selected from hydrosols, gels, gelatins, cellulose, cellulose derivatives and polysaccharide gums, said polymeric substance being in amount sufficient to significantly prolong viability of said sporozoites and said microcapsule wall comprised of hardened polymeric substance.
Claim 18
Independent Claim
87 words
A method of vaccinating warm-blooded animals against coccidiosis disease by administering to said animal a composition comprised of microcapsules containing internally, inside the microcapsule wall, a suspension of live excysted coccidial sporozoites, physiologically balanced with respect to isotonicity and pH and containing said suspension containing at least one water-soluble viscosity enhancing polymeric substances selected from hydrosols, gels, gelatins, cellulose, cellulose derivatives and polysaccharide gums, said polymeric substance being in amount sufficient to significantly prolong viability of said sporozoites and said microcapsule wall comprised of hardened polymeric substance.
Claim 19
Dependent Claim
21 words
The method of claim 13 wherein the water-soluble polysaccharide gum used is sodium alginate and the microcapsule wall is calcium alginate.
Claim 20
Dependent Claim
14 words
The method of claim 13 wherein the sporozoites are of the species Eimeria tenella.
References Cited (Backward Citations)
US4639372A
Cited
US4724145A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-28 | 1992-08-29 | 1993-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-28 | 1996-08-29 | 1997-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-28 | 2000-08-29 | 2001-02-28 | $7700.00 | Window Closed / Lapsed |