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US4802102A
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Baseline correction for chromatography
Assignee: Agilent Technologies Inc
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Filing: 1987-07-15
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Granted: 1989-01-31
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Expires: 2007-07-15
Abstract
Abstract Peak detection for a chromatogram is improved by removing systematic errors in the chromatogram using orthogonal subtraction. Orthogonal substraction involves subtracting from each spectrum in the chromatogram its expression in a spectral space representing the systematic errors. The data used in constructing the spectral space can be obtained in the form of spectra in the chromatogram occurring between component peaks. Principal component analysis can be applied to obtain a series of principal factors. A "hook method" can be applied to determine an optimum number of factors to use in constructing the spectral space, which is defined by the selected factors after normalization.
Inventors
- 👤 Richard F. Lacey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:22
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/86; G01N30/8624; G06; G06F; G06F2218/00; G06F2218/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
76 words
A system comprising: spectra means for generating a series of spectra, each spectrum in said series being constituted by plural data values taken at different wavelengths and a common respective time; orthonormal error space construction means for constructing an orthonormal spectral space from said series, said spectral space representing systematic errors in said series; and orthonormal subtraction means for subtracting from each spectrum in said series a projection of the same spectrum in said spectral space.
Claim 2
Independent Claim
76 words
A system comprising: spectra means for generating a series of spectra, each spectrum in said series being constituted by plural data values taken at different wavelengths and a common respective time; orthonormal error space construction means for constructing an orthonormal spectral space from said series, said spectral space representing systematic errors in said series; and orthonormal subtraction means for subtracting from each spectrum in said series a projection of the same spectrum in said spectral space.
Claim 3
Dependent Claim
13 words
The system of claim 1 wherein said series of spectra constitute a chromatogram.
Claim 4
Dependent Claim
70 words
The system of claim 2 further comprising identifier means for identifying systematic error spectra of said chromatogram representing systematic errors in said chromatogram, said identifier means being coupled to said spectra means for receiving a series of spectra therefrom, said identifier means being coupled to said constructions means so that said orthonormal spectral space can be constructed from a set of spectra representing systematic errors in said series of spectra.
Claim 5
Dependent Claim
23 words
The system of claim 3 wherein said construction means includes principal component means for performing principal component analysis on said systematic error spectra.
Claim 6
Dependent Claim
29 words
The system of claim 4 wherein said principal component means includes threshold means for determining a suitable number of principal components to be used in constructing said spectral space.
Claim 7
Independent Claim
58 words
A method comprising: generating a chromatogram having a series of spectra, each spectrum in said series being constituted by plural data values corresponding to different wavelengths and a common respective time; constructing a spectral space representing systematic errors in said chromatogram; and subtracting from each spectrum in said chromatogram a projection of that spectrum in said spectral space.
Claim 8
Independent Claim
58 words
A method comprising: generating a chromatogram having a series of spectra, each spectrum in said series being constituted by plural data values corresponding to different wavelengths and a common respective time; constructing a spectral space representing systematic errors in said chromatogram; and subtracting from each spectrum in said chromatogram a projection of that spectrum in said spectral space.
Claim 9
Dependent Claim
30 words
The method of claim 6 wherein said constructing step includes a substep of identifying systematic error spectra of said chromatogram, said systematic error spectra representing systematic errors in said chromatogram.
Claim 10
Dependent Claim
22 words
The method of claim 7 wherein said constructing step includes a subset of performing principal component analysis on said systematic error spectra.
Claim 11
Dependent Claim
28 words
The method of claim 8 wherein said constructing step includes a substep of determining a suitable number of principal components to be used in constructing said spectral space.
Claim 12
Independent Claim
130 words
A method of characterizing a composition represented in a time-evolving eluent, said method comprising the steps of: eluting said composition; spectrally analyzing said evolving eluent to obtain a chromatogram having a series of spectra, each spectrum in said series being constituted by plural data values taken at different wavelengths and a common respective time; selecting error spectra by selecting spectra of said series substantially devoid of contributions from said composition so that said error spectra represent systematic errors in said chromatogram; constructing a spectral space from said error spectra by determining orthogonal principle components of said error spectra; and subtracting from each spectrum of interest in said series a projection of that spectrum in said spectral space so as to obtain a corrected chromatogram substantially free of said systematic errors.
Claim 13
Independent Claim
130 words
A method of characterizing a composition represented in a time-evolving eluent, said method comprising the steps of: eluting said composition; spectrally analyzing said evolving eluent to obtain a chromatogram having a series of spectra, each spectrum in said series being constituted by plural data values taken at different wavelengths and a common respective time; selecting error spectra by selecting spectra of said series substantially devoid of contributions from said composition so that said error spectra represent systematic errors in said chromatogram; constructing a spectral space from said error spectra by determining orthogonal principle components of said error spectra; and subtracting from each spectrum of interest in said series a projection of that spectrum in said spectral space so as to obtain a corrected chromatogram substantially free of said systematic errors.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-31 | 1992-08-01 | 1993-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-31 | 1996-08-01 | 1997-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-31 | 2000-08-01 | 2001-01-31 | $7700.00 | Window Closed / Lapsed |