Patent US2760113A successfully refreshed from Google Patents.
US4786501A
Expired / Lapsed
US
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Cylindrical implants for the controlled release of growth hormones
Assignee: International Minerals and Chemical Corp
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Filing: 1985-07-15
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Granted: 1988-11-22
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Expires: 2005-07-15
Abstract
Abstract This invention relates to a method for purifying and concentrating biologically active growth hormone to produce growth hormone in a form suitable for incorporation into a controlled release device (or system). A buffered solution of purified recombinant growth hormone is dialyzed against a buffered solution until the salt level is reduced to less than 5% and then lyophilized.
Inventors
- 👤 Alvin M. Janski
- 👤 Ren-Der Yang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:08
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/0012; A61K9/0019; A61K9/0024; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61P; A61P43/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
91 words
A cylindrical implant for the controlled and continuous administration of growth hormone to a host comprising a compressed composition of an animal growth hormone produced by expression of a gene coding for the hormone in a transformant microorganism, said growth hormone being recovered from said microorganism and processed to produce a growth hormone containing less than 5% salt, and a biocompatible and growth hormone compatible polymer, said composition being surrounded along the length of the cylinder by a microporous polymer film and sealed at its ends by a non-porous polymer film.
Claim 2
Dependent Claim
91 words
A cylindrical implant for the controlled and continuous administration of growth hormone to a host comprising a compressed composition of an animal growth hormone produced by expression of a gene coding for the hormone in a transformant microorganism, said growth hormone being recovered from said microorganism and processed to produce a growth hormone containing less than 5% salt, and a biocompatible and growth hormone compatible polymer, said composition being surrounded along the length of the cylinder by a microporous polymer film and sealed at its ends by a non-porous polymer film.
Claim 3
Dependent Claim
19 words
The implant of claim 1 wherein the growth hormone is selected from bovine growth hormone and porcine growth hormone.
Claim 4
Dependent Claim
12 words
The implant of claim 2 wherein the compatible polymer is ethyl cellulose.
Claim 5
Dependent Claim
26 words
The implant of claim 2 wherein the compressed compostion contains about 30 weight percent growth hormone, 30 weight percent ethyl cellulose and 40 weight percent sucrose.
Claim 6
Dependent Claim
19 words
The implant of claim 2 wherein the microporous polymer is microporous polyethylene and the non-porous polymer is non-porous polyethylene.
Claim 7
Dependent Claim
29 words
The implant of claim 1 wherein the compressed composition contains from about 50-90 weight percent growth hormone and from about 10-50 weight percent biocompatible and growth hormone compatible polymer.
Claim 8
Dependent Claim
28 words
The implant of claim 6 wherein the biocompatible and growth hormone compatible polymer is ethylcellulose, the microporous polymer is microporous polyethylene and the non-porous polymer is non-porous polyethylene.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-22 | 1992-05-23 | 1992-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-22 | 1996-05-23 | 1996-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-22 | 2000-05-23 | 2000-11-22 | $7700.00 | Window Closed / Lapsed |