US4778786A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition for transdermal drug delivery
Assignee: FMG HOLDINGS Inc
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Filing: 1987-11-10
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Granted: 1988-10-18
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Expires: 2007-11-10
Abstract
Abstract As a composition for transdermal drug delivery, the gelation reaction product of a mixture of an organic polysaccharide gum, polyethylene glycol, and m-, p- or o-hydroxybenzoic acid in an amount effective in forming from such mixture a gel having adhesive properties for adhesion to skin and being sufficiently pliant to conform to the shape of body contours.
Inventors
- 👤 Richard Reever
- 👤 Larry Lundmark
- 👤 Timothy Kapsner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 21:05
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K9/70; A61K9/7007
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
27 words
As a composition for transdermal drug delivery, the gelation reaction product of a mixture comprising: an organic polysaccharide gum; polyethylene glycol; and m-, p- or o-hydroxybenzoic acid.
Claim 2
Dependent Claim
27 words
As a composition for transdermal drug delivery, the gelation reaction product of a mixture comprising: an organic polysaccharide gum; polyethylene glycol; and m-, p- or o-hydroxybenzoic acid.
Claim 3
Dependent Claim
15 words
The gelation reaction product of claim 1 wherein the organic polysaccharide gum is Sterculia gum.
Claim 4
Dependent Claim
32 words
The gelation reaction product of claim 1 wherein the m-, p- or o-hydroxybenzoic acid is o-hydroxybenzoic acid and such o-hydroxybenzoic acid is substantially solubilized in the reaction product for delivery to skin.
Claim 5
Dependent Claim
17 words
The gelation reaction product of claim 1 wherein the mixture further comprises a solubilized non-hydroxybenzoic acid drug.
Claim 6
Dependent Claim
14 words
The gelation reaction product of claim 4 wherein the solubilized non-hydroxybenzoic acid is hydroquinone.
Claim 7
Dependent Claim
50 words
The gelation reaction product of claim 1 wherein the amount of the m-, p- or o- hydroxybenzoic acid contained in the mixture is effective in forming from such a mixture a gel having structural integrity, being adhesive to skin and being pliant to conform to the shape of body contours.
Claim 8
Dependent Claim
48 words
The gelation reaction product of claim 6 wherein the organic polysaccharide gum is Sterculia gum and the m-, p- or o-hydroxybenzoic acid is o-hydroxybenzoic and the effective amount of the o-hydroxybenzoic acid is in the range of about 3 to 25 percent of the weight of the mixture.
Claim 9
Dependent Claim
29 words
The gelation reaction product of claim 7 wherein the amount of Sterculia gum is in the range of about 15 to 55 percent of the weight of the mixture.
Claim 10
Dependent Claim
14 words
The gelation reaction product of claim 1 wherein the mixture further comprises propylene glycol.
Claim 11
Dependent Claim
13 words
The gelation reaction product of claim 1 wherein the mixture further comprises glycerin.
Claim 12
Dependent Claim
44 words
The gelation reaction product of claim 1 wherein the polyethylene glycol is a polymer of ethylene oxide that conforms generally to the formula H(OCH 2 CH 2 ) n OH where n has some average value in the range of about 4 to 12.
Claim 13
Dependent Claim
21 words
The gelation reaction product of claim 11 wherein n has some average value in the range of about 4 to 6.
Claim 14
Dependent Claim
29 words
The gelation reaction product of claim 12 wherein the polyethylene glycol has the formula H(OCH 2 CH 2 ) 4 OH or H(OCH 2 CH 2 ) 6 OH.
Claim 15
Dependent Claim
14 words
The gelation reaction product of claim 1 wherein the mixture further comprises a perservative.
Claim 16
Dependent Claim
31 words
The gelation reaction product of claim 1 wherein the gelation reaction product is in the form of a mass less than 3 mm thick and less than 25 mm in diameter.
Claim 17
Dependent Claim
19 words
The gelation reaction product of claim 1 wherein the reaction product is a sheet less than 3 mm thick.
Claim 18
Dependent Claim
17 words
The gelation reaction product of claim 1 wherein the mixture further comprises a polymer of 2-acrylamido-2-methylpropanesulfonic acid.
Claim 19
Dependent Claim
27 words
The gelation reaction product of claim 17 wherein the molecular weight of the anionic portion of the polymer of 2-acrylamido-2-methylpropanesulfonic acid is from about 1,000,000 to 5,000,000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-18 | 1992-04-18 | 1992-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-18 | 1996-04-18 | 1996-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-18 | 2000-04-18 | 2000-10-18 | $7700.00 | Window Closed / Lapsed |