Patent US4772627A successfully refreshed from Google Patents.
US4772627A
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Ground mixture
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1987-01-15
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Granted: 1988-09-20
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Expires: 2007-01-15
Abstract
Abstract A ground mixture of a poorly soluble crystalline drug and an adsorbent is remarkably improved in the rates of dissolution and adsorption of the drug.
Inventors
- 👤 Masakazu Matsui
- 👤 Shigeharu Yokohama
- 👤 Toshio Kashihara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K9/00; A61K9/14; A61K9/141; A61K9/143
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
27 words
A ground mixture of an amorphous drug and an activated charcoal, wherein said mixture is prepared by grinding a poorly soluble crystalline drug and an activated charcoal.
Claim 2
Dependent Claim
27 words
A ground mixture of an amorphous drug and an activated charcoal, wherein said mixture is prepared by grinding a poorly soluble crystalline drug and an activated charcoal.
Claim 3
Dependent Claim
30 words
A ground mixture according to claim 1, wherein the activated charcoal has an adsorption ability of not less than 0.15 cm 3 /g as measured by the methanol adsorption method.
Claim 4
Dependent Claim
29 words
A ground mixture according to claim 1, wherein the activated charcoal has an adsorption ability of 0.15 to 1.50 cm 3 /g as measured by the methanol adsorption method.
Claim 5
Dependent Claim
21 words
A ground mixture according to claim 1, wherein the drug has a solubility in water of less than 1×10 -3 g/ml.
Claim 6
Dependent Claim
26 words
A ground mixture according to claim 1, wherein the ratio of the activated charcoal to the activated charcoal plus the drug is 20 to 60% (w/w).
Claim 7
Dependent Claim
26 words
A ground mixture according to claim 1, wherein the ratio of the activated charcoal to the activated charcoal plus the drug is 30 to 50% (w/w).
Claim 8
Independent Claim
25 words
A method for rendering a poorly soluble crystalline drug amorphous, which comprises grinding a mixture of said poorly soluble crystalline drug and an activated charcoal.
Claim 9
Independent Claim
25 words
A method for rendering a poorly soluble crystalline drug amorphous, which comprises grinding a mixture of said poorly soluble crystalline drug and an activated charcoal.
Claim 10
Dependent Claim
25 words
A method according to claim 7, wherein the ratio of the activated charcoal to the activated charcoal plus the drug is 30 to 50% (w/w).
Claim 11
Dependent Claim
16 words
A method according to claim 7, wherein an apparatus for the grinding is a vibrating mill.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |