Patent US4767753A successfully refreshed from Google Patents.
US4767753A
Expired / Lapsed
US
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Methods and compositions for preventing ulcers
Assignee: Procyte Corp
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Filing: 1987-05-11
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Granted: 1988-08-30
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Expires: 2007-05-11
Abstract
Abstract A variety of compositions suitable for use within methods for (a) reducing the formation of stomach ulcers in warm-blooded animals, (b) reducing the secretion of stomach acid in warm-blooded animals, and (c) increasing the secretion of ctyoprotective mucous in the stomach of warm-blooded animals are disclosed. The compositions include glycyl-L-histidyl-L-lysine, glycyl-L-histidyl-L-lysine: copper(II), and derivatives thereof.
Inventors
- 👤 Loren R. Pickart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:04
CPC Classifications
A; A61; A61K; A61K38/00; C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0827; A61K38/04; A61K38/06; A61P; A61P1/00; A61P1/04
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
26 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine.
Claim 2
Independent Claim
26 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine.
Claim 3
Independent Claim
27 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine: copper(II).
Claim 4
Independent Claim
27 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine: copper(II).
Claim 5
Independent Claim
84 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR2## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 6
Independent Claim
84 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR2## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 7
Independent Claim
92 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR3## wherein X is glycyl-L-alanyl, glycyl-L-seryl, or glycyl-L-valyl, and wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 8
Independent Claim
92 words
A method for reducing the secretion of stomach acid in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR3## wherein X is glycyl-L-alanyl, glycyl-L-seryl, or glycyl-L-valyl, and wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 9
Independent Claim
29 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine.
Claim 10
Independent Claim
29 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine.
Claim 11
Independent Claim
30 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine: copper(II).
Claim 12
Independent Claim
30 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine: copper(II).
Claim 13
Independent Claim
87 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR4## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 14
Independent Claim
87 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR4## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 15
Independent Claim
95 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR5## wherein X is glycyl-L-alanyl, glycyl-L-seryl, or glycyl-L-valyl, and wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 16
Independent Claim
95 words
A method for increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR5## wherein X is glycyl-L-alanyl, glycyl-L-seryl, or glycyl-L-valyl, and wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 17
Independent Claim
26 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine.
Claim 18
Independent Claim
26 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine.
Claim 19
Independent Claim
27 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine: copper(II).
Claim 20
Independent Claim
27 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a composition comprising glycyl-L-histidyl-L-lysine: copper(II).
Claim 21
Independent Claim
84 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR6## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 22
Independent Claim
84 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR6## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 23
Independent Claim
92 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR7## wherein X is glycyl-L-alanyl, glycyl-L-seryl, or glycyl-L-valyl, and wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
Claim 24
Independent Claim
92 words
A method for reducing the formation of stomach ulcers in warm-blooded animals, comprising: administering to the animal a therapeutically effective amount of a derivative of GHL-Cu having the general formula: ##STR7## wherein X is glycyl-L-alanyl, glycyl-L-seryl, or glycyl-L-valyl, and wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine.
References Cited (Backward Citations)
US4665054A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-30 | 1992-02-29 | 1992-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-30 | 1996-02-29 | 1996-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-30 | 2000-02-29 | 2000-08-30 | $7700.00 | Window Closed / Lapsed |