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US4760155A Expired / Lapsed US ⏱️ 0.0 years remaining

Platinum co-ordination compounds

Assignee: Johnson Matthey PLC
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Filing: 1986-06-11
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Granted: 1988-07-26
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Expires: 2006-06-11
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Abstract

Abstract Platinum co-ordination compounds comprising at least one amine ligand and a functional group remotely bonded to the amine ligand, which functional group may be linkable to a monoclonal antibody to provide a moiety which stabilizes the antibody against in vivo hydrolysis.

Inventors

  • 👤 James G. Heffernan
  • 👤 Paul C. Hydes
  • 👤 Donald H. Picker

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-28 10:53
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61P; A61P35/00

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 156 words
A co-ordination compound of platinum having the general formula ##STR16## in which the X groups are either the same or different and comprise monodentate ligands selected from the class consisting of halogen, pseudohalogen, sulphate, phosphate, nitrate, carboxylate and water, or together comprise a bidentate ligand selected from the class consisting of malonate, cycloalkanedicarboxylate and cycloalkenedicarboxylate ligands, R is selected from the class consisting of hydrogen, lower alkyl, aryl, aralkyl, alkenyl, cycloalkyl and cycloalkenyl, R' is selected from lower alkyl, aryl, alkaryl, aralkyl, alkenyl, cycloalkyl and cycloalkenyl residues, or R and R' together are selected from the class consisting of a methylene or polymethylene, cycloalkyl, cycloalkenyl or aryl residues, R" is hydrogen, methylene or polymethylene, and Y is a functionalising group selected from carboxylic acid and derivatives thereof, ethers, alcohol, thiol, amine, amide, sulphonamide, nitro and halo or forms an ether linkage with adjacent R' and R" groups when the R' and R" groups comprise methylene groups.
Claim 2
Dependent Claim 156 words
A co-ordination compound of platinum having the general formula ##STR16## in which the X groups are either the same or different and comprise monodentate ligands selected from the class consisting of halogen, pseudohalogen, sulphate, phosphate, nitrate, carboxylate and water, or together comprise a bidentate ligand selected from the class consisting of malonate, cycloalkanedicarboxylate and cycloalkenedicarboxylate ligands, R is selected from the class consisting of hydrogen, lower alkyl, aryl, aralkyl, alkenyl, cycloalkyl and cycloalkenyl, R' is selected from lower alkyl, aryl, alkaryl, aralkyl, alkenyl, cycloalkyl and cycloalkenyl residues, or R and R' together are selected from the class consisting of a methylene or polymethylene, cycloalkyl, cycloalkenyl or aryl residues, R" is hydrogen, methylene or polymethylene, and Y is a functionalising group selected from carboxylic acid and derivatives thereof, ethers, alcohol, thiol, amine, amide, sulphonamide, nitro and halo or forms an ether linkage with adjacent R' and R" groups when the R' and R" groups comprise methylene groups.
Claim 3
Dependent Claim 19 words
A compound according to claim 1 in which R' represents a polymethylene group which includes ether or ester groups.
Claim 4
Dependent Claim 17 words
A compound according to claim 1 modified by the addition of trans-bis hydroxy or -bis halo groups.
Claim 5
Dependent Claim 28 words
A pharmaceutical composition for the treatment of cancer comprising an effective amount of a compound according to claim 1 in association with a pharmaceutically-acceptable carrier, diluent or excipient.
Claim 6
Dependent Claim 10 words
A composition according to claim 4 in unit dosage form.

References Cited (Backward Citations)

US4372890A Cited
US4500465A Cited
EP0099133A2 Cited
US4560781A Cited
US4577038A Cited
US4607114A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1991-07-26 1992-01-25 1992-07-26 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1995-07-26 1996-01-25 1996-07-26 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1999-07-26 2000-01-25 2000-07-26 $7700.00 Window Closed / Lapsed

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