Novel platinum complexes

Abstract

Abstract This invention relates to a novel platinum-diamine complexes represented by the general formula: ##STR1## wherein R 1 and R 2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, ##STR2## or jointly represent a group represented by ##STR3## in which R 3 is a lower alkyl group or a group represented by --OM (wherein M is an atom which can become a monovalent cation); Y is --OH or a halogen atom; and n is 0 or 1, and n is 1 when R 1 and R 2 jointly represent an alkylene group having 5 carbon atoms and X is chlorine. The platinum-diamine complex of this invention has an excellent antitumor activity and a lower renal toxicity than cis-Platin now widely used as a carcinostatic as clinical medicine, and is expected as a carcinostatic lowered in toxicity.

Inventors

• 👤 Yuya Nakayama
• 👤 Kenji Iwata
• 👤 Katsutoshi Takahashi

Bibliographic Details