Patent US4758435A successfully refreshed from Google Patents.
US4758435A
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US
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Estradiol implant composition and method for preparation
Assignee: Wyeth Holdings LLC
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Filing: 1986-08-11
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Granted: 1988-07-19
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Expires: 2006-08-11
Abstract
Abstract The invention relates to biodegradable compositions which continuously release estradiol in a uniform manner over extended periods of time and do not exhibit initial release of undesirably high levels of active ingredient. The invention also relates to a method for preparation of the compositions, and a method for administering estradiol parenterally to feedlot animals in a continuous and uniform fashion over extended periods of time.
Inventors
- 👤 Mimi Y. C. Schaaf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K31/00; A61K31/56; A61K31/565; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
68 words
An improved biodegradable implant composition wherein the improvement comprises an implant containing on a weight basis 65% to 80% estradiol and 20% to 35% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 75/25 to 95/5 which has been washed with an alcohol, a ketone or an ether to provide a porous estradiol free coating having a pore size of less than twenty micrometers.
Claim 2
Dependent Claim
68 words
An improved biodegradable implant composition wherein the improvement comprises an implant containing on a weight basis 65% to 80% estradiol and 20% to 35% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 75/25 to 95/5 which has been washed with an alcohol, a ketone or an ether to provide a porous estradiol free coating having a pore size of less than twenty micrometers.
Claim 3
Dependent Claim
32 words
The composition according to claim 1 comprising 70% to 80% estradiol and 20% to 30% of a biodegradable poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 80/20 to 95/5.
Claim 4
Dependent Claim
23 words
The composition according to claim 2 comprising 70% to 75% estradiol and 25% to 30% poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio of 90/10.
Claim 5
Dependent Claim
28 words
An implant comprised of the composition according to claim 2 or 3 which is about 2.4 mm in diameter and from 4 mm to 6 mm in length.
Claim 6
Dependent Claim
18 words
The implant according to claim 4 which has been methanol washed to provide a porous estradiol free coating.
Claim 7
Dependent Claim
12 words
The implant according to claim 5 which is coated with oxytetracycline hydrochloride.
Claim 8
Independent Claim
93 words
A method for administering estradiol in a continuous and uniform manner for extended periods of time comprising, implanting a biodegradable composition about 2.4 mm in diameter and about 4 mm to about 6 mm in length comprising on a weight basis 65% to 80% estradiol and 20% to 35% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 75/25 to 95/5 which has been washed with an alcohol, a ketone or an ether to provide a porous estradiol free coating having a pore size of less than twenty micrometers.
Claim 9
Independent Claim
93 words
A method for administering estradiol in a continuous and uniform manner for extended periods of time comprising, implanting a biodegradable composition about 2.4 mm in diameter and about 4 mm to about 6 mm in length comprising on a weight basis 65% to 80% estradiol and 20% to 35% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 75/25 to 95/5 which has been washed with an alcohol, a ketone or an ether to provide a porous estradiol free coating having a pore size of less than twenty micrometers.
Claim 10
Dependent Claim
41 words
The method according to claim 7 wherein the composition comprises on a weight basis 70% to 80% estradiol and 20% to 30% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio of from 80/20 to 95/5; which is coated with oxytetracycline hydrochloride.
Claim 11
Dependent Claim
14 words
The method according to claim 8 in which the composition has been methanol washed.
Claim 12
Independent Claim
90 words
A method for the preparation of a biodegradable estradiol implant composition, with a porous coating, of about 2.4 mm in diameter and from about 4 mm to about 6 mm in length containing on a weight basis from 65% to 80% estradiol and 20% to 35% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 75/25 to 95/5 comprising washing the implant in an alcohol, a ketone or an ether to provide a porous estradiol free coating having a pore size of less than twenty micrometers.
Claim 13
Independent Claim
90 words
A method for the preparation of a biodegradable estradiol implant composition, with a porous coating, of about 2.4 mm in diameter and from about 4 mm to about 6 mm in length containing on a weight basis from 65% to 80% estradiol and 20% to 35% of a poly(lactide-co-glycolide) polymer having an 1-lactide/glycolide ratio in a range of from 75/25 to 95/5 comprising washing the implant in an alcohol, a ketone or an ether to provide a porous estradiol free coating having a pore size of less than twenty micrometers.
Claim 14
Dependent Claim
13 words
The method according to claim 10 wherein the implant is washed in methanol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-19 | 1992-01-18 | 1992-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-19 | 1996-01-18 | 1996-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-19 | 2000-01-18 | 2000-07-19 | $7700.00 | Window Closed / Lapsed |