US4191741A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Removable drug implant
Assignee: Eli Lilly and Co
•
Filing: 1978-09-22
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Granted: 1980-03-04
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Expires: 1998-09-22
Abstract
Abstract There is disclosed an implant which has an inert, biocompatible core with a coating comprising from about 5 to about 40% of estradiol in a biocompatible dimethylpolysiloxane rubber. When the implant is placed under the skin of a ruminant animal the estradiol is released at a substantially constant rate to produce a greater than normal weight gain in the animal. The implant remains intact and may be removed from the animal at the end of the desired period of drug administration.
Inventors
- 👤 James L. Hudson
- 👤 Jack F. Wagner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:05
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/20; A61K9/2072; A61K9/2086
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
80 words
A solid, cylindrical, subcutaneous implant for improving the rate of weight gain of ruminant animals which comprises (a) a biocompatible inert core having a diameter of from about 2 to about 10 mm. and (b) a biocompatible coating having a thickness of from about 0.2 to about 1 mm., the composition of said coating comprising from about 5 to about 40 percent by weight of estradiol and from about 95 to about 60 percent by weight of a dimethylpolysiloxane rubber.
Claim 2
Dependent Claim
80 words
A solid, cylindrical, subcutaneous implant for improving the rate of weight gain of ruminant animals which comprises (a) a biocompatible inert core having a diameter of from about 2 to about 10 mm. and (b) a biocompatible coating having a thickness of from about 0.2 to about 1 mm., the composition of said coating comprising from about 5 to about 40 percent by weight of estradiol and from about 95 to about 60 percent by weight of a dimethylpolysiloxane rubber.
Claim 3
Dependent Claim
14 words
An implant of claim 1 wherein the biocompatible inert core is a silicone rubber.
Claim 4
Dependent Claim
49 words
An implant of claim 1 wherein the diameter of the inert core is from about 3.5 to about 4.5 mm., the thickness of the coating is from about 0.25 to about 0.5 mm., and the concentration of estradiol in the coating is from about 15 to about 25 percent.
Claim 5
Dependent Claim
14 words
An implant of claim 3 wherein the biocompatible inert core is a silicone rubber.
Claim 6
Dependent Claim
17 words
An implant of claim 4 wherein the concentration of estradiol in the coating is about 20 percent.
Claim 7
Dependent Claim
25 words
A method for the administration of estradiol to a ruminant animal which comprises placing an implant of claim 1 under the skin of the animal.
Claim 8
Dependent Claim
25 words
A method for the administration of estradiol to a ruminant animal which comprises placing an implant of claim 5 under the skin of the animal.
References Cited (Backward Citations)
US3279996A
Cited
US3499445A
Cited
USRE28536E
Cited
US3545439A
Cited
US3920805A
Cited
US4012497A
Cited
US4012496A
Cited
US3946106A
Cited
US3992518A
Cited
US4053580A
Cited
US4096239A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-04 | 1983-09-03 | 1984-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-04 | 1987-09-03 | 1988-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-04 | 1991-09-03 | 1992-03-04 | $7700.00 | Window Closed / Lapsed |