US4755386A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Buccal formulation
Assignee: Key Pharmaceuticals Inc
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Filing: 1986-01-22
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Granted: 1988-07-05
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Expires: 2006-01-22
Abstract
Abstract A buccal formulation for administering a medicament includes about 1-20% by weight of a soluble, pharmaceutically acceptable adhesive, about 1-10% by weight of a pharmaceutically acceptable disintegrant and a soluble, directly compressible tablet excipient.
Inventors
- 👤 Chiin H. Hsiao
- 👤 Janice L. Cacace
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
55 words
A buccal composition for administration of an active ingredient comprising; (a) about 1 to about 20% by weight of a soluble, pharmaceutically acceptable polymeric adhesive; (b) about 1 to about 10% by weight of a pharmaceutically acceptable table disintegrant; (c) a soluble, directly compressible table excipient; and (d) a therapeutically useful amount of active ingredient.
Claim 2
Dependent Claim
55 words
A buccal composition for administration of an active ingredient comprising; (a) about 1 to about 20% by weight of a soluble, pharmaceutically acceptable polymeric adhesive; (b) about 1 to about 10% by weight of a pharmaceutically acceptable table disintegrant; (c) a soluble, directly compressible table excipient; and (d) a therapeutically useful amount of active ingredient.
Claim 3
Dependent Claim
29 words
The composition of claim 1, wherein said adhesive is selected from the group consisting of a carbomer, partially hydrolyzed polyvinyl alcohol, polyethylene oxide, polyacrylate, hydroxypropyl methylcellulose and hydroxypropyl cellulose.
Claim 4
Dependent Claim
11 words
The composition of claim 2, wherein the adhesive is a carbomer.
Claim 5
Dependent Claim
12 words
The composition of claim 3, wherein the adhesive is carbomer 934 P.
Claim 6
Dependent Claim
25 words
The composition of claim 1, wherein said disintegrant is selected from the group consisting of crospovidone, cross-linked carboxylic methylcellulose, alginic acid and sodium carboxymethyl starch.
Claim 7
Dependent Claim
11 words
The composition of claim 5, wherein said disintegrant is cross-linked polyvinylpyrrolidone.
Claim 8
Dependent Claim
18 words
The composition of claim 1, wherein the amount of adhesive is about 2 to about 10% by weight.
Claim 9
Dependent Claim
18 words
The composition of claim 1, wherein the amount of disintegrant is about 3 to about 6% by weight.
Claim 10
Dependent Claim
11 words
The composition of claim 1, wherein said excipient is a sugar.
Claim 11
Dependent Claim
33 words
The composition of claim 1, wherein said active ingredient is selected from the group consisting of an estrogen, a progestin, an androgen, an anabolic steroid, propranolol, insulin, ACTH, physostigmine, scopolamine, verapamil, and gallopamil.
Claim 12
Dependent Claim
17 words
The composition of claim 10, wherein the active ingredient is estradiol or a pharmaceutically acceptable derivative thereof.
Claim 13
Dependent Claim
17 words
The composition of claim 11, wherein the amount of estradiol is about 50 micrograms to 2 mg.
Claim 14
Dependent Claim
40 words
A buccal composition for administration of an estrogen, comprising: (a) about 2 to about 10% by weight of carbomer 934P; (b) about 3 to about 6% by weight crospovidone; (c) sugar; and (d) a therapeutically useful amount of an estrogen.
Claim 15
Dependent Claim
40 words
A buccal composition for administration of an estrogen, comprising: (a) about 2 to about 10% by weight of carbomer 934P; (b) about 3 to about 6% by weight crospovidone; (c) sugar; and (d) a therapeutically useful amount of an estrogen.
Claim 16
Dependent Claim
19 words
The composition of claim 13, wherein the estrogenis estradiol, in the amount of about 50 micrograms to 2 mg.
Claim 17
Dependent Claim
66 words
A buccal composition for transmucosal administration of an effective amount of an active ingredient comprising: (a) about 1 to about 20% by weight of a soluble, pharmaceutically acceptable polymeric adhesive; (b) about 1 to about 10% by weight of a pharmaceutically acceptable table disintegrant admixed with said polymeric adhesive; (c) a soluble, directly compressible table excipient, and (d) a therapeutically useful amount of an active ingredient.
Claim 18
Dependent Claim
66 words
A buccal composition for transmucosal administration of an effective amount of an active ingredient comprising: (a) about 1 to about 20% by weight of a soluble, pharmaceutically acceptable polymeric adhesive; (b) about 1 to about 10% by weight of a pharmaceutically acceptable table disintegrant admixed with said polymeric adhesive; (c) a soluble, directly compressible table excipient, and (d) a therapeutically useful amount of an active ingredient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-05 | 1992-01-04 | 1992-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-05 | 1996-01-04 | 1996-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-05 | 2000-01-04 | 2000-07-05 | $7700.00 | Window Closed / Lapsed |