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US4745179A
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59 Valine insulin-like growth factor I and process for production thereof
Assignee: Astellas Pharma Inc
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Filing: 1985-03-20
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Granted: 1988-05-17
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Expires: 2005-03-20
Abstract
Abstract The present invention relates to a 59Valine insulin-like growth factor I (59Val.IGF-I), to a 59Val-IGF-I fused to a protective peptide, to a gene coding for 59Val-IGF-I, to a gene coding for fused 59Val-IGF-I, to a plasmid containing the 59Val-IGF-I gene, to a host organism containing a plasmid containing the 59Val-IGF-I gene, to a host organism containing a plasmid containing the fused 59Val-IGF-I gene, and to processes for the production of these.
Inventors
- 👤 Ikuo Ueda
- 👤 Mineo Niwa
- 👤 Yoshimasa Saito
- 👤 Susumu Sato
- 👤 Hiroki Ono
- 👤 Tadashi Kitaguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:11
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/65; C07K14/59; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/70; C07K2319/00; C07K2319/01; C07K2319/036; C07K2319/70; C07K2319/74; C07K2319/75; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12; Y10S930/26
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
31 words
A 59 valine insulin-like growth factor I (hereinafter referred to as 59 Val-IGF-I) fused to a protein peptide LH, wherein said 59 Val-IGF-I has the following amino acid sequence: Gly-Pro-Glu-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Val-Tyr-Cys-Ala-Pro- eu-Lys-Pro-Ala-Lys-Ser-Ala.
Claim 2
Dependent Claim
31 words
A 59 valine insulin-like growth factor I (hereinafter referred to as 59 Val-IGF-I) fused to a protein peptide LH, wherein said 59 Val-IGF-I has the following amino acid sequence: Gly-Pro-Glu-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Val-Tyr-Cys-Ala-Pro- eu-Lys-Pro-Ala-Lys-Ser-Ala.
Claim 3
Dependent Claim
20 words
The 59 Val-IGF-I fused with protein peptide LH of claim 1, having the following amino acid sequence: Cys-Tyr-Cys-Gln-Asp-Pro-Tyr-Val-Lys-Glu-Ala-Glu-Asn-Leu-Lys-Lys-Tyr-Phe-Asn-Ala-Gly-His-Ser-Asp-Val-Ala-Asp-Asn-Gly-Thr-Leu-Phe-Leu-Gly-Ile-Leu-Lys-Asn-Trp-Lys-Glu-Glu-Ser-Asp-Arg-Lys-Ile-Met-Gln-Ser-Gln-Ile-Val-Ser-Phe-Tyr-Phe-Lys-Leu-Glu-Val-Lys-His Glu-Phe-Met-Gly-Pro-Glu-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Val-Ty -Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala.
Claim 4
Dependent Claim
23 words
The 59 Val-IGF-I fused protein peptide LH of claim 1, wherein said protein peptide LH has the following amino acid sequence: Cys-Tyr-Cys-Gln-Asp-Pro-Tyr-Val-Lys-Glu-Ala-Glu-Asn-Leu-Lys-Lys-Tyr-Phe-Asn-Ala-Gly-His-Ser-Asp-Val-Ala-Asp-Asn-Gly-Thr-Leu-Phe-Leu-Gly-Ile-Leu-Lys-Asn-Trp-Lys-Glu-Glu-Ser-Asp-Arg-Lys-Ile-Met-Gln-Ser-Gln-Ile-Val-Ser-Phe-Tyr-Phe-Lys-Leu-Glu-Val-Lys-His Glu-Phe-Met.
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