Patent US5017887A successfully refreshed from Google Patents.
Patent US4740502A successfully refreshed from Google Patents.
US4740502A
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Semisynthetic erythromycin antibiotics
Assignee: Abbott Laboratories
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Filing: 1986-06-20
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Granted: 1988-04-26
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Expires: 2006-06-20
Abstract
Abstract Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. Certain 4"-carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced gastrointestinal stimulation compared to the parent compounds.
Inventors
- 👤 Steven M. Hannick
- 👤 Larry L. Klein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:30
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
109 words
A compound of the formula ##STR3## wherein R 1 is selected from hydroxyl or acyl of 2 to 20 carbon atoms, R 2 is hydrogen or methyl, R 3 and R 4 are independently selected from hydrogen or alkyl of 1 to 12 carbon atoms, R 5 is hydrogen or halogen, X is O═ or R 6 N═ where R 6 is C 1 to C 8 alkyl, alkoxyalkyl, or aryl and Y--Y' is ##STR4## where R 7 is hydrogen or hydroxyl and Z is O═ or R 8 N═ where R 8 is hydrogen, hydroxy, alkyl, substituted alkyl, alkoxy, aryl, or substituted aryl, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
109 words
A compound of the formula ##STR3## wherein R 1 is selected from hydroxyl or acyl of 2 to 20 carbon atoms, R 2 is hydrogen or methyl, R 3 and R 4 are independently selected from hydrogen or alkyl of 1 to 12 carbon atoms, R 5 is hydrogen or halogen, X is O═ or R 6 N═ where R 6 is C 1 to C 8 alkyl, alkoxyalkyl, or aryl and Y--Y' is ##STR4## where R 7 is hydrogen or hydroxyl and Z is O═ or R 8 N═ where R 8 is hydrogen, hydroxy, alkyl, substituted alkyl, alkoxy, aryl, or substituted aryl, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 wherein R 1 is acetyl.
Claim 4
Dependent Claim
32 words
A compound according to claim 2 wherein R 2 , R 3 and R 4 are all hydrogen, X is O═, and Y--Y' has the formula ##STR5## wherein R 7 is hydroxyl.
Claim 5
Dependent Claim
32 words
A pharmaceutical composition in unit dosage form, comprising a compound according to claim 1 in an amount effective to treat an infection caused by susceptible microorganisms in combination with a pharmaceutical carrier.
Claim 6
Dependent Claim
38 words
A method of treating infections caused by susceptible microorganisms in humans and lower animals in need of such treatment, comprising administering to the human or lower animal a therapeutically effective amount of a composition according to claim 4.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-26 | 1991-10-26 | 1992-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-26 | 1995-10-26 | 1996-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-26 | 1999-10-26 | 2000-04-26 | $7700.00 | Window Closed / Lapsed |