Patent US4738844A successfully refreshed from Google Patents.
US4738844A
Expired / Lapsed
US
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Modified (1-28) beta interferons
Assignee: GD Searle LLC
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Filing: 1984-06-22
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Granted: 1988-04-19
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Expires: 2004-06-22
Abstract
Abstract Modified beta interferons containing amino acid substitutions in the beta interferon amino acids 1 to 28 are described. These modified beta interferons exhibit changes in the antiviral, cell growth regulatory or immunomodulatory activities when compared with unmodified beta interferon.
Inventors
- 👤 Leslie D. Bell
- 👤 John C. Smith
- 👤 Paul G. Boseley
- 👤 Michael Houghton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:33
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/107; C07K1/113; C07K1/1133; C07K14/00; C07K14/435; C07K14/52; C07K14/555; C07K14/565; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/142
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
30 words
A modified beta interferon comprising a beta interferon wherein amino acids 2 to 7 of said beta interferon are replaced by amino acids 1 to 5 of alpha 2 interferon.
Claim 2
Dependent Claim
30 words
A modified beta interferon comprising a beta interferon wherein amino acids 2 to 7 of said beta interferon are replaced by amino acids 1 to 5 of alpha 2 interferon.
Claim 3
Dependent Claim
46 words
A modified beta interferon comprising a beta interferon wherein amino acids 2 to 7 of said beta interferon are replaced by amino acids 1 to 5 of alpha H interferon polypeptide and the cysteine located at position 17 of natural beta interferon is replaced with serine.
Claim 4
Dependent Claim
46 words
A modified beta interferon comprising a beta interferon wherein amino acids 2 to 7 of said beta interferon are replaced by amino acids 1 to 5 of alpha H interferon polypeptide and the cysteine located at position 17 of natural beta interferon is replaced with serine.
Claim 5
Dependent Claim
45 words
A modified beta interferon comprising a beta interferon wherein amino acids 2 to 7 of said beta interferon are replaced by amino acids 1 to 5 of alpha 2 interferon and the cysteine located at position 17 of natural beta interferon is replaced with serine.
Claim 6
Dependent Claim
45 words
A modified beta interferon comprising a beta interferon wherein amino acids 2 to 7 of said beta interferon are replaced by amino acids 1 to 5 of alpha 2 interferon and the cysteine located at position 17 of natural beta interferon is replaced with serine.
Claim 7
Dependent Claim
31 words
A modified beta interferon comprising a beta interferon wherein amino acids 3 to 28 of said beta interferon are replaced by amino acids 2 to 26 of an alpha 1 interferon.
Claim 8
Dependent Claim
31 words
A modified beta interferon comprising a beta interferon wherein amino acids 3 to 28 of said beta interferon are replaced by amino acids 2 to 26 of an alpha 1 interferon.
Claim 9
Dependent Claim
46 words
A modified beta interferon comprising a beta interferon wherein amino acids 3 to 7 of said beta interferon are replaced by amino acids 2 to 5 of alpha 2 interferon and the cysteines located at position 17 of natural beta interferon polypeptide is replaced with serine.
Claim 10
Dependent Claim
46 words
A modified beta interferon comprising a beta interferon wherein amino acids 3 to 7 of said beta interferon are replaced by amino acids 2 to 5 of alpha 2 interferon and the cysteines located at position 17 of natural beta interferon polypeptide is replaced with serine.
Claim 11
Dependent Claim
42 words
A pharmaceutical composition for use in the treatment of viral infections or neoplastic disease or for stimulating the immune system in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 1 admixed with a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
28 words
A pharmaceutical composition for treating viral infections in an animal comprising an effective amount of the modified beta interferon of claim 2 admixed with a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
28 words
A pharmaceutical composition for treating viral infections in an animal comprising an effective amount of the modified beta interferon of claim 3 admixed with a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
28 words
A pharmaceutical composition for treating viral infections in an animal comprising an effective amount of the modified beta interferon of claim 4 admixed with a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
28 words
A pharmaceutical composition for treating viral infections in an animal comprising an effective amount of the modified beta interferon of claim 5 admixed with a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
29 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective amount of a modified beta interferon of claim 1.
Claim 17
Dependent Claim
29 words
A method of regulating cell growth in an animal in need of such treatment comprising the administration of an effective amount of a modified beta interferon of claim 1.
Claim 18
Dependent Claim
30 words
A method of regulating the immune system in an animal in need of such treatment comprising the administration of an effective amount of a modified beta interferon of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-19 | 1991-10-19 | 1992-04-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-19 | 1995-10-19 | 1996-04-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-19 | 1999-10-19 | 2000-04-19 | $7700.00 | Window Closed / Lapsed |