Patent US3834965A successfully refreshed from Google Patents.
Patent US4734505A successfully refreshed from Google Patents.
US4734505A
Expired / Lapsed
US
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1-(alkylated)-2-(acylated)diazolidinones
Assignee: Eli Lilly and Co
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Filing: 1986-05-14
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Granted: 1988-03-29
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Expires: 2006-05-14
Abstract
Abstract 1-(Alkylated)-2-(acylated)diazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds. The instant compounds have the formula ##STR1## wherein R 1 , R 2 , R 3 , and R 4 are as defined in the specification.
Inventors
- 👤 Richard E. Holmes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 19:14
CPC Classifications
C; C07; C07D; C07D409/00; C07D409/02; C07D409/06; A; A61; A61P; A61P31/00; A61P31/04; C07D231/00; C07D231/02; C07D231/06; C07D231/08; C07D487/00; C07D487/02; C07D487/04; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/645; C07F9/6503; C07F9/65031; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
154 words
A compound of the formula: ##STR9## wherein: R 1 is a carboxy-protecting group or a non-toxic, metabolically-labile, esterforming group; R 2 is C 1 to C 6 alkyl, C 1 to C 6 substituted alkyl, perfluoro C 2 to C 4 alkyl, C 7 to C 12 arylalkyl, C 7 to C 12 substituted arylalkyl, phenyl, substituted phenyl, or a heterocyclic ring; a group of the formula --CX.sub.3 wherein X is fluoro, chloro, bromo or iodo; or a group of the formula --S--R.sub.5 wherein R 5 is C 1 to C 6 alkyl, C 1 to C 6 substituted alkyl, phenyl, substituted phenyl, C 7 to C 12 arylalkyl, C 7 to C 12 substituted arylalkyl or a heterocyclic ring; and R 3 and R 4 are: (1) each hydrogen; (2) taken together and form a phthalimido group; or (3) different and are either hydrogen or an amino-protecting group; or a pharmaceutically-acceptable salt thereof.
Claim 2
Dependent Claim
154 words
A compound of the formula: ##STR9## wherein: R 1 is a carboxy-protecting group or a non-toxic, metabolically-labile, esterforming group; R 2 is C 1 to C 6 alkyl, C 1 to C 6 substituted alkyl, perfluoro C 2 to C 4 alkyl, C 7 to C 12 arylalkyl, C 7 to C 12 substituted arylalkyl, phenyl, substituted phenyl, or a heterocyclic ring; a group of the formula --CX.sub.3 wherein X is fluoro, chloro, bromo or iodo; or a group of the formula --S--R.sub.5 wherein R 5 is C 1 to C 6 alkyl, C 1 to C 6 substituted alkyl, phenyl, substituted phenyl, C 7 to C 12 arylalkyl, C 7 to C 12 substituted arylalkyl or a heterocyclic ring; and R 3 and R 4 are: (1) each hydrogen; (2) taken together and form a phthalimido group; or (3) different and are either hydrogen or an amino-protecting group; or a pharmaceutically-acceptable salt thereof.
Claim 3
Dependent Claim
29 words
A compound of claim 1, wherein R 1 is a carboxy protecting group, and either R 3 or R 4 is hydrogen and the other is an amino-protecting group.
Claim 4
Dependent Claim
12 words
A compound of claim 2, wherein R 2 is a heterocyclic ring.
Claim 5
Dependent Claim
12 words
A compound of claim 3, wherein R 2 is a 2-thienyl group.
Claim 6
Dependent Claim
26 words
A compound of claim 4, wherein R 1 is p-nitrobenzyl, and either R 3 or R 4 is hydrogen and the other is a t-butoxycarbonyl group.
Claim 7
Dependent Claim
9 words
A compound of claim 1 of the formula ##STR10##
Claim 8
Dependent Claim
28 words
A compound of claim 6, wherein R 1 is a carboxy-protecting group and either R 3 or R 4 is hydrogen and the other is an amino-protecting group.
References Cited (Backward Citations)
US4465679A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-29 | 1991-09-28 | 1992-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-29 | 1995-09-28 | 1996-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-29 | 1999-09-28 | 2000-03-29 | $7700.00 | Window Closed / Lapsed |