1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof

Claim 1

A compound of the formula and its pharmaceutically-acceptable acid addition salts, wherein X is a saturated chain of 1 to 5 carbon atoms; A and A' are independently hydroxy, alkoxy, phenoxy, or hydroxyamino; R 1 , R 2 , R 3 , R 4 , R 6 and R 7 are independently hydrogen, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, fused cycloalkyl-phenyl, fused phenyl-cycloalkyl, fused cycloalkylphenyl-alkyl, fused phenyl-cycloalkyl-alkyl, phenoxyalkyl, phenylalkyloxyalkyl, cycloalkyl, or cycloalkyl-alkyl, and R 4 can in addition be keto-oxygen or, when X contains at least 2 carbon atoms, R 4 can be a phenyl ring fused to 2 consecutive atoms of X or a cycloalkyl ring fused to X; and R 5 can be hydrogen, alkyl, alkenyl, alkynyl, alkanoyl, benzoyl, phenyl-alkanoyl, carbamoyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, phenyl, phenylalkyl, polyphenyl, fused cycloalkyl-phenyl, fused phenyl-cycloalkyl, fused phenyl-cyclo-alkyl-alkyl, or fused cycloalkyl-phenyl-alkyl; wherein the alkyl, alkoxy, alkenoxy, alkenyl, and alkynyl groups can carry one or more substituents selected from the group consisting of hydroxy, alkanoyloxy, benzoyloxy, phenylalkanoyl, carbamoyl, phenyl, alkoxy, phenoxy, amino, mono- or dialkylamino, alkanoylamino, benzoylamino, mercapto, mercaptoalkyl, and alkylthio; the cycloalkyl rings can carry one or more substituents selected from the group consisting of alkyl, hydroxy, alkylamino, and nitro; and the phenyl rings can carry one or more substituents selected from the group consisting of carboxylic acid, cyano, carboxy-lower alkoxy, alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, trifluoroalkyl, mercapto, alkylthio, mercaptoalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, and sulfamyl; wherein the alkyl groups and moieties contain 1 to 9 carbon atoms; the alkenyl and alkynyl groups and moieties contain 2 to 9 carbon atoms; the polycycloalkyl groups have up to 20 carbon atoms; and the cycloalkyl groups and the cycloalkyl portions of substituents containing cycloalkyl groups contain 3 to 9 carbon atoms.