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US4734222A Expired / Lapsed US ⏱️ 0.0 years remaining

Composition and method for cleaning soft and hard contact lenses

Assignee: Novartis Corp
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Filing: 1986-04-03
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Granted: 1988-03-29
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Expires: 2006-04-03
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Abstract

Abstract An opthalmic cleaning composition for cleaning a contact lens comprising an effective amount of a water soluble particulate compound for removing proteinaceous, lipid and other non-proteinaceous deposits on the contact lens, wherein the particulate compound is suspended in a predominately non-aqueous water-miscible organic liquid medium which is substantially a non-solvent for the particulate compound, and a method of cleaning a contact lens employing such composition.

Inventors

  • 👤 Lynn Winterton
  • 👤 Kai C. Su

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 09:05
CPC Classifications
C; C11; C11D; C11D17/00; C11D17/0008; C11D17/0013; C11D3/00; C11D3/0005; C11D3/0078; C11D7/00; C11D7/22; C11D7/26; C11D7/261; C11D7/263; C11D7/265; C11D7/268; C11D7/32; C11D7/3227; C11D7/50; C11D7/5004; C11D7/5022; C11D1/00; C11D1/38; C11D1/42; C11D1/44; C11D1/52; C11D1/526; C11D1/66; C11D1/72; C11D1/74

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 181 words
A heterogeneous composition for cleaning a contact lens comprising a contact lens cleaning effective amount of an ocularly acceptable, water-soluble, particulate organic compound selected from sodium p-aminosalicylate, amphetamine sulfate, arginine glutamate, bismuth sodium tartarte, calcium disodium edetate, calcium lactate, citric acid, disodium edetate, ephedrine hydrochloride, ephedrine bitartrate, a sugur, D-glucuronic acid, heparin sodium, mannitol, N-methylglucamine, sodium citrate, sodium succinate, tartaric acid, and trisodium ededate monohydrate, said particulate compound having a particle size between about 1 micron and below about 750 microns and substantially devoid of soft contact lens tearing irrregularities, which compound, in aqueous solution at a concentration between about 3 and 20% by weight, is isosmotic with isotonic sodium chloride; and a predominantly non-aqueous, water-miscible, substantially non-ionic, ocularly acceptable, organic liquid suspending medium which is substantially a non solvent for said particulate compound and is selected from polypropylene glycol, polyethylene glycol, polyethoxylated alkanols of 6-20 carbons, polysorbates, tyloxapol, polyethoxylated alkylphenols, polyethoxylated polypropylene glycols, polyethoxylated fatty acids, polyethoxylated fatty acid amides, polyethoxylated amines, ethoxylated monoglycerides of fatty acids, and higher alkyl amine oxides; said compound being dispersed in said suspending medium.
Claim 2
Dependent Claim 181 words
A heterogeneous composition for cleaning a contact lens comprising a contact lens cleaning effective amount of an ocularly acceptable, water-soluble, particulate organic compound selected from sodium p-aminosalicylate, amphetamine sulfate, arginine glutamate, bismuth sodium tartarte, calcium disodium edetate, calcium lactate, citric acid, disodium edetate, ephedrine hydrochloride, ephedrine bitartrate, a sugur, D-glucuronic acid, heparin sodium, mannitol, N-methylglucamine, sodium citrate, sodium succinate, tartaric acid, and trisodium ededate monohydrate, said particulate compound having a particle size between about 1 micron and below about 750 microns and substantially devoid of soft contact lens tearing irrregularities, which compound, in aqueous solution at a concentration between about 3 and 20% by weight, is isosmotic with isotonic sodium chloride; and a predominantly non-aqueous, water-miscible, substantially non-ionic, ocularly acceptable, organic liquid suspending medium which is substantially a non solvent for said particulate compound and is selected from polypropylene glycol, polyethylene glycol, polyethoxylated alkanols of 6-20 carbons, polysorbates, tyloxapol, polyethoxylated alkylphenols, polyethoxylated polypropylene glycols, polyethoxylated fatty acids, polyethoxylated fatty acid amides, polyethoxylated amines, ethoxylated monoglycerides of fatty acids, and higher alkyl amine oxides; said compound being dispersed in said suspending medium.
Claim 3
Dependent Claim 36 words
The composition of claim 1 wherein said particle size is between about 1 and 500 microns and said compound is present in said composition in an amount of from about 1 to about 60% by weight.
Claim 4
Dependent Claim 13 words
The composition of claim 1 wherein said compound is a water-soluble crystalline compound.
Claim 5
Dependent Claim 18 words
The composition of claim 1 wherein said compound, upon solution with water is substantially non-irritating to the eye.
Claim 6
Dependent Claim 25 words
The composition of claim 4 wherein said compound, in aqueous solution between about 8 and about 12% by weight, is isosotic with isotonic sodium chloride.
Claim 7
Dependent Claim 11 words
The composition of claim 1 wherein said compound is a sugar.
Claim 8
Dependent Claim 10 words
The composition of claim 6 wherein said sugar is sucrose.
Claim 9
Dependent Claim 70 words
A method of cleaning a contact lens contaminated with proteinaceous and non-proteinaceous deposits comprising (1) applying onto the surface of a contact lens to be cleaned, an effective cleaning amount of the composition of claim 1; (2) rubbing said composition onto said surface for a period sufficient to remove said proteinaceous and said non-proteinaceous deposits therefrom; and (3) then contacting sid lens with an aqueous solution to rinse said lens.
Claim 10
Independent Claim 266 words
A method of cleaning a contact lens contaminated with proteinaceous and non-proteinaceous deposits comprising (1) applying onto the surface of a contact lens to be cleaned, an effective cleaning amount of a heterogeneous composition suitable for cleaning said lens comprising a contact lens cleaning effective amount of an ocularly acceptable, water-soluble, particulate compound selected from sodium p-aminosalicylate, amphetamine sulfate, arginine glutamate, bismuth sodium tartrate, calcium disodium edetate, calcium lactate, citric acid, disodium edette, ephedrine hydrochloride, ephedrine bitartrate, a sugar, D-glucuronic acid, heparin sodium, mannitol, N-methyglucamine, sodium citrate, sodium sucinate, tartaric acid, trisodium ededate monohydrate, potassium alum, magnesium sulfate, dibasic sodium phosphate dodecahydrate, sodium sulfate, and zinc sulfate, said particulate compound having a particle size between fabout 1 micron and below about 750 microns and substantially devoid of soft contact lens tearing irregularities, which compound, in aqueous solution at a concentration between about 3 and 20% by weight, is isosmotic with isotonic sodium chloride; and a predominantly non-aqueous, water-miscible, substantially non-ionic, ocularly acceptable, organic liquid suspending medium which is substantially a non solvent for said particulate compound and is selected from polypropylene glycol, polyethylene glycol, polyethoxylated alkanols of 6-20 carbons, polysorbates, tyloxdapol, polyethoxyated alkylphenols, polyethoxylated polypropylene glycols, polyethoxylated fatty acids, polyethoxylated fatty acid amides, polyethoxylated amines, ethoxylated monoglycerides of fatty acids, higher alkyl amine oxides, glycerine, lower alkanols, lower alkyl ethers, and lower alkyl esters, said compound being dispersed in said suspending medium, (2) rubbing said composition onto said surface for a period sufficient to remove said proteiaceous and said non-proteinaceous deposits therefrom; and (3) then contacting said lens with an aqueous solution to rinse said lens.
Claim 11
Independent Claim 266 words
A method of cleaning a contact lens contaminated with proteinaceous and non-proteinaceous deposits comprising (1) applying onto the surface of a contact lens to be cleaned, an effective cleaning amount of a heterogeneous composition suitable for cleaning said lens comprising a contact lens cleaning effective amount of an ocularly acceptable, water-soluble, particulate compound selected from sodium p-aminosalicylate, amphetamine sulfate, arginine glutamate, bismuth sodium tartrate, calcium disodium edetate, calcium lactate, citric acid, disodium edette, ephedrine hydrochloride, ephedrine bitartrate, a sugar, D-glucuronic acid, heparin sodium, mannitol, N-methyglucamine, sodium citrate, sodium sucinate, tartaric acid, trisodium ededate monohydrate, potassium alum, magnesium sulfate, dibasic sodium phosphate dodecahydrate, sodium sulfate, and zinc sulfate, said particulate compound having a particle size between fabout 1 micron and below about 750 microns and substantially devoid of soft contact lens tearing irregularities, which compound, in aqueous solution at a concentration between about 3 and 20% by weight, is isosmotic with isotonic sodium chloride; and a predominantly non-aqueous, water-miscible, substantially non-ionic, ocularly acceptable, organic liquid suspending medium which is substantially a non solvent for said particulate compound and is selected from polypropylene glycol, polyethylene glycol, polyethoxylated alkanols of 6-20 carbons, polysorbates, tyloxdapol, polyethoxyated alkylphenols, polyethoxylated polypropylene glycols, polyethoxylated fatty acids, polyethoxylated fatty acid amides, polyethoxylated amines, ethoxylated monoglycerides of fatty acids, higher alkyl amine oxides, glycerine, lower alkanols, lower alkyl ethers, and lower alkyl esters, said compound being dispersed in said suspending medium, (2) rubbing said composition onto said surface for a period sufficient to remove said proteiaceous and said non-proteinaceous deposits therefrom; and (3) then contacting said lens with an aqueous solution to rinse said lens.

References Cited (Backward Citations)

US3630929A Cited
US3850831A Cited
US3981826A Cited
US3776851A Cited
US4065324A Cited
US4394179A Cited
US4326979A Cited
US4493783A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1991-03-29 1991-09-28 1992-03-29 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1995-03-29 1995-09-28 1996-03-29 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1999-03-29 1999-09-28 2000-03-29 $7700.00 Window Closed / Lapsed

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