US4726949A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Irradiation of blood products
Assignee: Baxter International Inc
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Filing: 1986-08-26
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Granted: 1988-02-23
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Expires: 2006-08-26
Abstract
Abstract A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.
Inventors
- 👤 Jeffrey E. Miripol
- 👤 Arnold Bilstad
- 👤 John Foley
- 👤 Dean Glash
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:49
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3681; A61M1/3616; A61M2205/00; A61M2205/05; A61M2205/051; A61M2205/053
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
83 words
The method of treating white blood cells comprising irradiating a thin film of a blood product containing white blood cells with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers at an intensity of 4 to 15 milliwatts per square cm., to provide a total energy exposure of 800 to 2800 millijoules per square cm. of ultraviolet radiation for a sufficient time, whereby said white blood cells substantially lose their capability to set off an immune reaction in an alloimmunized patient.
Claim 2
Independent Claim
83 words
The method of treating white blood cells comprising irradiating a thin film of a blood product containing white blood cells with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers at an intensity of 4 to 15 milliwatts per square cm., to provide a total energy exposure of 800 to 2800 millijoules per square cm. of ultraviolet radiation for a sufficient time, whereby said white blood cells substantially lose their capability to set off an immune reaction in an alloimmunized patient.
Claim 3
Dependent Claim
23 words
The method of claim 1 in which said blood product is irradiated while occupying a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic.
Claim 4
Dependent Claim
34 words
The method of claim 2 in which said plastic contains from 10 to 30 weight percent by weight of vinyl acetate units and said bag has a wall thickness of 0.005 to 0.025 inch.
Claim 5
Dependent Claim
20 words
The method of claim 1 in which said thin film of blood product is from 0.1 to 5 cm. thick.
Claim 6
Dependent Claim
16 words
The method of claim 1 in which said irradiation is from 0.25 to 15 minutes long.
Claim 7
Dependent Claim
35 words
The method of claim 1 in which said blood product is irradiated while occupying a flat, flexible bag which is stretched during said irradiation to define said thin film of blood product within said bag.
Claim 8
Dependent Claim
19 words
The method of claim 1 in which said total energy exposure is 1600 to 2500 millijoules per square cm.
Claim 9
Dependent Claim
17 words
The method of claim 1 in which said intensity is 7 to 11 milliwatts per square cm.
Claim 10
Dependent Claim
17 words
The method of claim 1 in which said irradiating takes place without agitation of the thin film.
Claim 11
Dependent Claim
20 words
The method of claim 1 in which said ultraviolet radiation is predominately of a wavelength of 300 to 320 nanometers.
Claim 12
Independent Claim
97 words
The method of treating white blood cells comprising irradiating a thin film of blood product containing white blood cells with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, which comprises: presenting said blood product to the radiation while said blood product occupies a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, said plastic containing from 10 to 30 percent of vinyl acetate units, and said bag having a wall thickness of 0.005 to 0.025 inch, whereby said white blood cells substantially lose their capability to set off an immune reaction in an aloimmunized patient.
Claim 13
Independent Claim
97 words
The method of treating white blood cells comprising irradiating a thin film of blood product containing white blood cells with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, which comprises: presenting said blood product to the radiation while said blood product occupies a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, said plastic containing from 10 to 30 percent of vinyl acetate units, and said bag having a wall thickness of 0.005 to 0.025 inch, whereby said white blood cells substantially lose their capability to set off an immune reaction in an aloimmunized patient.
Claim 14
Dependent Claim
26 words
The method of claim 11 in which said bag is axially stretched during said irradiation to define said think film of blood product within said bag.
Claim 15
Dependent Claim
21 words
The method of claim 12 in which said thin film of white blood cells is from 0.1 to 5 cm. thick.
Claim 16
Independent Claim
103 words
The method of treating white blood cells comprising irradiating a thin film of blood product containing white blood cells with ultraviolet radiation predominately of a wavelength between 280 to 320 nanometers at an intensity of 7 to 11 milliwatts per square cm., without agitation of the film, to provide a total energy exposure of 800 to 2800 millijoules per square cm. of ultraviolet radiation, in which said blood product is irradiated while occupying a flat, flexible bag which is stretched during said irradiation to define said thin film of white blood cells within said bag, said bag being made of poly(ethylene-vinyl acetate) plastic.
Claim 17
Independent Claim
103 words
The method of treating white blood cells comprising irradiating a thin film of blood product containing white blood cells with ultraviolet radiation predominately of a wavelength between 280 to 320 nanometers at an intensity of 7 to 11 milliwatts per square cm., without agitation of the film, to provide a total energy exposure of 800 to 2800 millijoules per square cm. of ultraviolet radiation, in which said blood product is irradiated while occupying a flat, flexible bag which is stretched during said irradiation to define said thin film of white blood cells within said bag, said bag being made of poly(ethylene-vinyl acetate) plastic.
Claim 18
Dependent Claim
31 words
The method of claim 14 which said plastic contains from 10 to 30 weight percent of vinyl acetate units, and said bag has a wall thickness of 0.005 to 0.025 inch.
Claim 19
Dependent Claim
16 words
The method of claim 14 in which said irradiation is from 0.25 to 15 minutes long.
Claim 20
Dependent Claim
21 words
The method of claim 14 in which said thin film of white blood cells is from 0.1 to 5 cm. thick.
Claim 21
Dependent Claim
25 words
The method of claim 15 in which the total energy exposure of ultraviolet radiation applied is 1600 to 2500 millijoules per square cm. 2 .
References Cited (Backward Citations)
US4612007A
Cited
US4608255A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-22 | 1991-08-24 | 1992-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-22 | 1995-08-24 | 1996-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-22 | 1999-08-24 | 2000-02-23 | $7700.00 | Window Closed / Lapsed |