US4612007A
Expired / Lapsed
US
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Method and system for externally treating the blood
Assignee: Edelson Trust
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Filing: 1982-12-08
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Granted: 1986-09-16
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Expires: 2002-12-08
Abstract
Abstract A method and system are disclosed for externally treating human blood, with the objective of reducing the functioning lymphocyte population in the blood system of a human subject. According to the method, blood is withdrawn from the subject and passed through an ultraviolet radiation field in the presence of from about 1 nanogram to 100 micrograms per ml of blood, of a dissolved photoactive agent capable of forming photo-adducts with lymphocytic-DNA, mobile hormonal receptors or antigen sites to thereby effect covalent bonding between the photoactive agent and the same, thereby inhibiting the metabolic processes of the lymphocytes or complexing them; and thereupon returning the irradiated blood to the subject. The withdrawn blood may be formed into an extracorporeal stream and flowed through a treatment station whereat the irradiation is effected, as for example by exposure to UV radiation; and such flow process may be conducted on a continuous basis. If desired, at least portions of the treated blood may then be separated, as for example, by a continuous centrifuge, before returning the remaining diverted blood to the subject.
Inventors
- 👤 Richard L. Edelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:24
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3681; A61K; A61K41/00; A61K41/10; A61M1/3616; A61M1/3683; A61M1/3686; A61M1/3621; A61M1/3623; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
115 words
A method for reducing the functioning population of a blood constituent in the blood supply of a human subject, comprising the steps of: withdrawing blood from said subject, and irradiating said withdrawn blood with UV radiation in the presence of an effective amount of a dissolved photoactive chemical agent specific for a receptor site in or on the blood constituent and capable when activated by said UV radiation of forming photo-adducts with blood constituent receptor sites, to thereby effect chemical bonding between said photoactivated chemical agent and said receptor sites, thereby initiating the destruction and/or removal of said blood constituent from the blood supply of the subject and returning the irradiated blood to said subject.
Claim 2
Independent Claim
115 words
A method for reducing the functioning population of a blood constituent in the blood supply of a human subject, comprising the steps of: withdrawing blood from said subject, and irradiating said withdrawn blood with UV radiation in the presence of an effective amount of a dissolved photoactive chemical agent specific for a receptor site in or on the blood constituent and capable when activated by said UV radiation of forming photo-adducts with blood constituent receptor sites, to thereby effect chemical bonding between said photoactivated chemical agent and said receptor sites, thereby initiating the destruction and/or removal of said blood constituent from the blood supply of the subject and returning the irradiated blood to said subject.
Claim 3
Dependent Claim
13 words
The method according to claim 1 wherein the blood constituent comprises activated T-lymphocytes.
Claim 4
Dependent Claim
39 words
The method according to claim 1 wherein the photoactivated chemical agent comprises a polypeptide selected from the group consisting of insulin, interleukin, thymopoietin and transferrin, and wherein said agent further comprises a photocytotoxic chemical agent covalently-linked to said polypeptide.
Claim 5
Dependent Claim
49 words
The method according to claim 1 wherein the photoactivated chemical agent comprises a liposome, said liposome having an antibody or a polypeptide capable of binding to said constituent receptor site covalently linked to its outer surface, and said liposome internally incorporating an effective amount of a photocytotoxic agent therein.
Claim 6
Dependent Claim
21 words
The method according to claim 4 wherein the polypeptide is selected from the group consisting of insulin, interleukin, thymopoietin and transferrin.
Claim 7
Dependent Claim
27 words
The method according to claim 4 wherein said antibody is a monoclonal antibody and said liposome is from about 500 angstroms to about 0.5 micrometers in diameter.
Claim 8
Independent Claim
44 words
The method according to claims 3 or 4 wherein the photocytotoxic chemical agent comprises a moiety selected from the group consisting of psoralen, pyrene cholesteryloleate, acridine, porphyrin, fluorescein, rhodamine, 16-diazocortisone, ethidium, transition metal complexes of bleomycin, transition metal complexes of deglycobleomycin and organoplatinum complexes.
Claim 9
Independent Claim
16 words
The method according to claims 3 or 4 wherein the covalent linkage comprises a disulfide moiety.
Claim 10
Dependent Claim
31 words
The method according to claim 4 further comprising the step of separating at least portions of said photoactivated chemical agent-blood constituent complex by dialysis, before returning said blood to said subject.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-15 | 1990-03-17 | 1990-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-15 | 1994-03-17 | 1994-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-15 | 1998-03-17 | 1998-09-16 | $7700.00 | Window Closed / Lapsed |