Patent US4725586A successfully refreshed from Google Patents.
US4725586A
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Surgical solution
Assignee: Individual
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Filing: 1986-03-04
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Granted: 1988-02-16
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Expires: 2006-03-04
Abstract
Abstract A surgical or irrigation solution which provides the anterior and posterior chamber of the eye with protection during surgical procedures that require irrigation. This irrigation solution is composed of a HEPES buffered Eagle's Minimum Essential Media (MEM) with Earle's Salts, without phenol red, supplemented with mixed isomers of 99% pure, chondroitin sulfate, MEM non-essential amino acids, 2-mercaptoethanol, and sodium pyruvate. Other solutions include a balanced salt solution, chondroitin sulfate, buffers and 2-mercaptoethanol. The solution can also be used in other surgical or medical applications.
Inventors
- 👤 Richard L. Lindstrom
- 👤 Debra Skelnik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 09:20
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
75 words
A composition for irrigating of flushing body tissue during surgical procedures, which composition comprises effective amounts of: a. balanced salt solution comprising sodium chloride, potassium chloride, a sodium phosphate buffer system, calcium chloride, and magnesium chloride, the solution having a pH of about 7.4; b. chondroitin sulfate; c. a buffer system based on N'-2-2hydroxyethylpiperazine-N'-ethane sulfonic acid; d. 2-mercaptoethanol; e. sodium bicarbonate or dextrose; f. a pyruvate; g. a sodium phosphate buffer system; and, h. cystine.
Claim 2
Dependent Claim
75 words
A composition for irrigating of flushing body tissue during surgical procedures, which composition comprises effective amounts of: a. balanced salt solution comprising sodium chloride, potassium chloride, a sodium phosphate buffer system, calcium chloride, and magnesium chloride, the solution having a pH of about 7.4; b. chondroitin sulfate; c. a buffer system based on N'-2-2hydroxyethylpiperazine-N'-ethane sulfonic acid; d. 2-mercaptoethanol; e. sodium bicarbonate or dextrose; f. a pyruvate; g. a sodium phosphate buffer system; and, h. cystine.
Claim 3
Dependent Claim
12 words
The composition of claim 1 lacking components (e), (f), (g) and (h).
Claim 4
Dependent Claim
10 words
The composition of claim 1 lacking components (g) and (h).
Claim 5
Dependent Claim
8 words
The composition of claim 1 lacking component (h).
Claim 6
Dependent Claim
36 words
The composition of claim 2 in which component (b) is present at a concentration of 0.1-5% by weight, and components (c) and (d) are present at concentrations of about 1 mM-30 mM and 0.001-1 mM, respectively.
Claim 7
Dependent Claim
22 words
The composition of claim 2 additionally containing at least one of: a. ascorbic acid; b. glutathione; c. DL-L-tocopherol; or, d. sialic acid.
Claim 8
Dependent Claim
45 words
The composition of claim 6 in which component (a) is present at a concentration of about 0.01-0.2 mM; component (b) is present at about 0.1 ug/ml-5 mg/ml; component (c) is present at about 0.001 ug/ml-0.1 ug/ml; and component (d) is present at about 0.001-1 mM.
Claim 9
Dependent Claim
24 words
A method of irrigating or flushing body tissue during surgical procedures which comprises bringing the composition of claim 1 into contact with said tissue.
Claim 10
Dependent Claim
24 words
A method of irrigating or flushing body tissue during surgical procedures which comprises bringing the composition of claim 2 into contact with said tissue.
Claim 11
Dependent Claim
24 words
A method of irrigating or flushing body tissue during surgical procedures which comprises bringing the composition of claim 3 into contact with said tissue.
Claim 12
Dependent Claim
24 words
A method of irrigating or flushing body tissue during surgical procedures which comprises bringing the composition of claim 5 into contact with said tissue.
Claim 13
Dependent Claim
24 words
A method of irrigation or flushing body tissue during surgical procedures which comprises bringing the composition of claim 4 into contact with said tissue.
Claim 14
Dependent Claim
24 words
A method of irrigating or flushing body tissue during surgical procedures which comprises bringing the composition of claim 6 into contact with said tissue.
References Cited (Backward Citations)
US4486416A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-15 | 1991-08-17 | 1992-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-15 | 1995-08-17 | 1996-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-15 | 1999-08-17 | 2000-02-16 | $7700.00 | Window Closed / Lapsed |