US4725428A
Expired / Lapsed
US
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Dental caries-preventive composition containing antibody
Assignee: Lion Corp
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Filing: 1985-11-06
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Granted: 1988-02-16
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Expires: 2005-11-06
Abstract
Abstract There is provided a dental caries-preventive composition containing an antibody and a nonionic surface active agent, said antibody being obtained from an animal immunized with cells or cell components of Streptococcus mutans. The dental caries-preventive composition inhibits the formation of dental plaque and prevents dental caries. It keeps the antibody stable for a long period of time and hence permits the antibody to exhibit its effect with certainty over a long period of time.
Inventors
- 👤 Tsuneo Miyahara
- 👤 Yoshihiro Harada
- 👤 Katsuyuki Futakami
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:06
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K39/00; A61K39/395; A61K39/39591; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/96; A61K8/99; C; C07; C07K; C07K16/00; C07K16/12; C07K16/1267; C07K16/1275; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
164 words
A dental composition, comprising: an effective amount to inhibit the colonization of Streptococcus mutans in the mouth of an antibody against a strain or mutant of human Streptococcus mutans serotype c, d, e, f or g; and an effective amount to stabilize said antibody of a nonionic surface active agent selected from the group consisting of alkanolamide fatty acid esters having 9 to 18 carbon atoms in the fatty acid group and 2 to 3 carbon atoms in the alkanol group, sucrose fatty acid esters having 8 to 18 carbon atoms in the fatty acid group and a degree of esterification of 0.8 to 3, polyoxyethylene sorbitan fatty acid esters having 8 to 20 carbon atoms in the fatty acid group, 6 to 60 mol of ethylene oxide added and a degree of esterification of 1 to 3, polyoxyethylene fatty acid esters having 8 to 20 carbon atoms in the fatty acid group 1 to 60 mol of ethylene oxide added and mixtures thereof.
Claim 2
Dependent Claim
164 words
A dental composition, comprising: an effective amount to inhibit the colonization of Streptococcus mutans in the mouth of an antibody against a strain or mutant of human Streptococcus mutans serotype c, d, e, f or g; and an effective amount to stabilize said antibody of a nonionic surface active agent selected from the group consisting of alkanolamide fatty acid esters having 9 to 18 carbon atoms in the fatty acid group and 2 to 3 carbon atoms in the alkanol group, sucrose fatty acid esters having 8 to 18 carbon atoms in the fatty acid group and a degree of esterification of 0.8 to 3, polyoxyethylene sorbitan fatty acid esters having 8 to 20 carbon atoms in the fatty acid group, 6 to 60 mol of ethylene oxide added and a degree of esterification of 1 to 3, polyoxyethylene fatty acid esters having 8 to 20 carbon atoms in the fatty acid group 1 to 60 mol of ethylene oxide added and mixtures thereof.
Claim 3
Dependent Claim
19 words
The composition of claim 1, wherein said antibody is against a strain or mutan of human Streptococcus mutans serotype-c.
Claim 4
Dependent Claim
13 words
The composition of claim 1, which is in the form of a toothpaste.
Claim 5
Dependent Claim
13 words
The composition of claim 3, which includes aluminum hydroxide as a main abrasive.
Claim 6
Dependent Claim
11 words
The composition of claim 1, which includes carrageenan as a binder.
Claim 7
Dependent Claim
13 words
The composition of claim 1, which includes gelatin, peptone, casein, collagen or albumin.
Claim 8
Dependent Claim
202 words
A dental composition, comprising: 0.0002 to 10% by weight, based on the weight of the composition, or an antibody obtained by immunizing an antibody producing mammal with cells or a mutant of human Streptococcus mutans serotype c, d, e, f or g or antigenic cell components thereof selected from the group consisting of cell wall fraction, fibrous structure fraction, pilus component fraction, glucosyltransferase fraction and protein antigen fraction; and 0.1 to 3% by weight, based on the weight of the composition, of a nonionic surface active agent selected from the group consisting of alkanolamide fatty acid esters having 9 to 18 carbon atoms in the fatty acid group and 2 to 3 carbon atoms in the alkanol group, sucrose fatty acid esters having 8 to 18 carbon atoms in the fatty acid group and a degree of esterification of 0.8 to 3, polyoxyethylene sorbitan fatty acid esters having 8 to 20 carbon atoms in the fatty acid group, 6 to 60 mol of ethylene oxide added and a degree of esterification of 1 to 3, polyoxyethylene fatty acid esters having 8 to 20 carbon atoms in the fatty acid group and 1 to 60 mol of ethylene oxide added and mixtures thereof.
Claim 9
Dependent Claim
202 words
A dental composition, comprising: 0.0002 to 10% by weight, based on the weight of the composition, or an antibody obtained by immunizing an antibody producing mammal with cells or a mutant of human Streptococcus mutans serotype c, d, e, f or g or antigenic cell components thereof selected from the group consisting of cell wall fraction, fibrous structure fraction, pilus component fraction, glucosyltransferase fraction and protein antigen fraction; and 0.1 to 3% by weight, based on the weight of the composition, of a nonionic surface active agent selected from the group consisting of alkanolamide fatty acid esters having 9 to 18 carbon atoms in the fatty acid group and 2 to 3 carbon atoms in the alkanol group, sucrose fatty acid esters having 8 to 18 carbon atoms in the fatty acid group and a degree of esterification of 0.8 to 3, polyoxyethylene sorbitan fatty acid esters having 8 to 20 carbon atoms in the fatty acid group, 6 to 60 mol of ethylene oxide added and a degree of esterification of 1 to 3, polyoxyethylene fatty acid esters having 8 to 20 carbon atoms in the fatty acid group and 1 to 60 mol of ethylene oxide added and mixtures thereof.
Claim 10
Dependent Claim
18 words
The composition of claim 7, wherein said antibody producing mammal is a goat, sheep, horse, cow or rabbit.
Claim 11
Dependent Claim
17 words
The composition of claim 7, wherein the mutant is variant K-Dp, KH2, or K-III of Streptococcus mutans.
Claim 12
Dependent Claim
13 words
The composition of claim 17, which further comprises an anionic surface active agent.
Claim 13
Dependent Claim
24 words
The composition of claim 10, wherein the ratio of nonionic surface active agent to anionic surface active agent is 0.4:1 to 3:1 by weight.
Claim 14
Dependent Claim
18 words
The composition of claim 10, wherein the anionic surface active agent is a water-soluble salt of alkyl sulfate.
Claim 15
Dependent Claim
15 words
The composition of claim 7, which is in the form of a toothpaste or mouthwash.
Claim 16
Dependent Claim
13 words
The composition of claim 7, which includes aluminum hydroxide as a main abrasive.
Claim 17
Dependent Claim
11 words
The composition of claim 7, which includes carrageenan as a binder.
Claim 18
Dependent Claim
13 words
The composition of claim 7, which includes gelatin, peptone, casein, collagen or albumin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-15 | 1991-08-17 | 1992-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-15 | 1995-08-17 | 1996-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-15 | 1999-08-17 | 2000-02-16 | $7700.00 | Window Closed / Lapsed |