US3931398A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for local immunization against dental caries
Assignee: Colgate Palmolive Co
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Filing: 1973-06-20
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Granted: 1976-01-06
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Expires: 1993-06-20
Abstract
Abstract Immunization against dental caries by local administration, in the vicinity of the oral mucosa of an animal susceptible to dental caries, of a vaccine containing a polyfructan or polyglucan polysaccharide, or a levansucrase or dextransucrase enzyme. The polysaccharides may be administered in purified form, or may be in the form of dead cells of the streptococci by which they are elaborated. Polyglucan polysaccharides so useful are produced by elaboration of strains of the species S.mutans and S.sanguis, while the polyfructan which may be incorporated in the vaccine may be an elaboration product of Streptomyces Strain SS2.
Inventors
- 👤 Abdul Gaffar
- 👤 Hans Wilhelm Marcussen, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:03
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/09; A61K39/092; A61K31/00; A61K31/70; A61K31/715; A61K38/00; A61K38/16; A61K38/43; A61K38/45; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/66; A61K8/72; A61K8/73; A61Q; A61Q11/00; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/885
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
96 words
In a method for immunization against dental caries, which comprises administering subcutaneously by injection a vaccine, the improvement which comprises locally administering into or near the oral cavity a vaccine constituting an aqueous saline dispersion of an active ingredient selected from the group consisting of (1) a polyglucan polysaccharide elaboration product of a strain of microorganism of the species S.mutans or S.sanguis, and (2) a polyfructan polysaccharide elaboration product of a strain of microorganism within the genus streptococcus, to an animal susceptible to dental caries, said active ingredient being administered in an amount effective for immunization.
Claim 2
Dependent Claim
96 words
In a method for immunization against dental caries, which comprises administering subcutaneously by injection a vaccine, the improvement which comprises locally administering into or near the oral cavity a vaccine constituting an aqueous saline dispersion of an active ingredient selected from the group consisting of (1) a polyglucan polysaccharide elaboration product of a strain of microorganism of the species S.mutans or S.sanguis, and (2) a polyfructan polysaccharide elaboration product of a strain of microorganism within the genus streptococcus, to an animal susceptible to dental caries, said active ingredient being administered in an amount effective for immunization.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein said vaccine is administered into or near the major or minor salivary glands.
Claim 4
Dependent Claim
29 words
The method of claim 1, wherein the polyglucan or polyfructan is incorporated in the vaccine in the form of dead cells of the microorganism from which it is elaborated.
Claim 5
Dependent Claim
61 words
The method of claim 1, wherein the polyfructan is the active ingredient of said vaccine, the polyfructan incorporating a molecular weight fraction having characteristic infrared absorption peaks at 920 cm. - 1 , 875 cm. - 1 and 805 cm. - 1 , an intrinsic viscosity at 25° C of from 0.15-0.16, and [α] D 20 rotation of 43° to 54°.
Claim 6
Dependent Claim
25 words
The method of claim 1, wherein the polyfructan is the active ingredient of said vaccine, said polyfructan being an elaboration product of Streptococcus Strain SS2.
Claim 7
Dependent Claim
25 words
The method of claim 1, wherein the polyglucan is the active ingredient of said vaccine, said polyglucan being an elaboration product of S.mutans Strain 6715.
Claim 8
Dependent Claim
21 words
The method of claim 1, wherein the vaccine is administered by injection into the chin of the animal to be immunized.
Claim 9
Dependent Claim
13 words
The method of claim 1 wherein said vaccine is administered by direct injection.
Claim 10
Dependent Claim
12 words
The method of claim 1, wherein the vaccine additionally contains Freund's adjuvant.
Claim 11
Dependent Claim
36 words
The method of claim 1, wherein the polysaccharide is administered in the vaccine in an amount equivalent to from 1 to 20 micrograms thereof per kilogram of the body weight of the animal to be immunized.
References Cited (Backward Citations)
DE2212739A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-05 | 1979-07-07 | 1980-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-05 | 1983-07-07 | 1984-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-05 | 1987-07-07 | 1988-01-06 | $7700.00 | Window Closed / Lapsed |