US3879545A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vaccines for the prevention of dental caries
Assignee: Individual
•
Filing: 1973-05-16
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Granted: 1975-04-22
•
Expires: 1993-05-16
Abstract
Abstract Vaccines are prepared from a levan-producing strain of Streptococcus, especially Streptococcus Strain SS2, in the prevention, via immunization, of dental caries. The levan may be used in pure form or may be used in the form of the crude extracellular polysaccaride thereof to produce the vaccine material. Killed Streptococcus SS2 cells containing the extracellular polysaccharide may also be used in lieu of either the pure levan or the polysaccaride material.
Inventors
- 👤 Abdul Gaffar
- 👤 Richard Charles Kestenbaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:02
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/73; A61K39/00; A61K39/02; A61K39/09; A61K39/092; A61K8/96; A61K8/99; A61Q; A61Q11/00; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/885
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
69 words
A VACCINE FOR IMMUNIZATION AGAINST DENTAL CARIES, WHICH COMPRISES AN AQUEOUS, SALINE DISPERSION OF FROM 0.1 TO 1 GRAM PER LITER OF A LEVAN-POLYSACCHARIDE ELABORATION PRODUCT OF A LEVAN-PRODUCING STRAIN OF THE GENUS STREPTOCOCCUS, SAID LEVANPOLYSACCHARIDE HAVING A MOLECULAR WEIGHT FRACTION HAVING CHARACTERISTIC INFRA-RED ABSORPTION PEAKS AT 920 CM.-1, 875 CM.-1 AND 805 CM.-1 AN INTRINSIC VISCOSITY AT 25*C OF FROM 0.15:0.16, AND (A)20 ROTATION OF 43* TO 54*.
Claim 2
Dependent Claim
69 words
A VACCINE FOR IMMUNIZATION AGAINST DENTAL CARIES, WHICH COMPRISES AN AQUEOUS, SALINE DISPERSION OF FROM 0.1 TO 1 GRAM PER LITER OF A LEVAN-POLYSACCHARIDE ELABORATION PRODUCT OF A LEVAN-PRODUCING STRAIN OF THE GENUS STREPTOCOCCUS, SAID LEVANPOLYSACCHARIDE HAVING A MOLECULAR WEIGHT FRACTION HAVING CHARACTERISTIC INFRA-RED ABSORPTION PEAKS AT 920 CM.-1, 875 CM.-1 AND 805 CM.-1 AN INTRINSIC VISCOSITY AT 25*C OF FROM 0.15:0.16, AND (A)20 ROTATION OF 43* TO 54*.
Claim 3
Dependent Claim
75 words
A vaccine for immunization against dental caries, which comprises an aqueous, saline dispersion of from 0.1 to 1 gram per liter of a levan-polysaccharide elaboration product of a levan-producing strain of the genus Streptococcus, said levan-polysaccharide having a molecular weight fraction having characteristic infra-red absorption peaks at 920 cm. 1, 875 cm. 1 and 805 cm. 1, an intrinsic viscosity at 25* C of from 0.15-0.16, and ( Alpha )D20 rotation of 43* to 54*.
Claim 4
Dependent Claim
75 words
A vaccine for immunization against dental caries, which comprises an aqueous, saline dispersion of from 0.1 to 1 gram per liter of a levan-polysaccharide elaboration product of a levan-producing strain of the genus Streptococcus, said levan-polysaccharide having a molecular weight fraction having characteristic infra-red absorption peaks at 920 cm. 1, 875 cm. 1 and 805 cm. 1, an intrinsic viscosity at 25* C of from 0.15-0.16, and ( Alpha )D20 rotation of 43* to 54*.
Claim 5
Dependent Claim
23 words
The vaccine of claim 1, wherein the levan-polysaccharide is dissolved therein in an amount of from 0.4 to 0.6 grams per liter thereof.
Claim 6
Dependent Claim
14 words
The vaccine of claim 1, wherein the strain of Streptococcus is Streptococcus Strain SS2.
Claim 7
Dependent Claim
19 words
The vaccine of claim 3, wherein the levan-polysaccharide is supplied in the form of dead Streptococcus Strain SS2 cells.
Claim 8
Dependent Claim
18 words
The vaccine of claim 3, wherein the levan-polysaccharide has a molecular weight range of 16 to 23 million.
Claim 9
Dependent Claim
31 words
A method for immunizing a host against the formation of dental caries, which comprises administering an effective amount of the vaccine of claim 1 to a host susceptible to dental caries.
Claim 10
Dependent Claim
28 words
The method of claim 6, wherein the amount of the levan-polysaccharide administered corresponds to between 1 and 20 micrograms of said polysaccharide per kilogram of host body weight.
Claim 11
Dependent Claim
28 words
The method of claim 6, wherein the amount of the levan-polysaccharide administered corresponds to between 5 and 10 micrograms of said polysaccharide per kilogram of host body weight.
References Cited (Backward Citations)
US2944941A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-21 | 1978-10-21 | 1979-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-21 | 1982-10-21 | 1983-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-21 | 1986-10-21 | 1987-04-22 | $7700.00 | Window Closed / Lapsed |