Patent US4724233A successfully refreshed from Google Patents.
US4724233A
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Therapeutical application of phosphonylmethoxyalkyl adenines
Assignee: Stichting Rega VZW
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Filing: 1986-04-21
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Granted: 1988-02-09
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Expires: 2006-04-21
Abstract
Abstract The (S) and (RS) forms of certain phosphonylmethoxyalkyl adenines and their salts have an antiviral effect against several DNA viruses and can be used for the treatment of virus diseases in human and veterinary medicine.
Inventors
- 👤 Erik De Clercq
- 👤 Antonin Holy
- 👤 Ivan Rosenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/675; A61P; A61P31/00; A61P31/12; A61P31/20; A61P31/22; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
118 words
A method for treating virus diseases, which comprises administering to a patient in need of said treatment an effective antiviral amount of a phosphonylmethoxyalkyladenine of the formula (I) ##STR3## wherein R 1 is methylene, --CH(OH)--CH 2 -- or ##STR4## and R 2 is a hydroxyl group, and, wherein, when R 1 is different from methylene, R 1 and R 2 may be linked with each other to form a cyclic ester group, said adenine derivative being in (RS) or (S) form when R 1 is different from methylene and further being in the form of a free acid or a salt thereof wherein the salts are selected from the group consisting of alkali metal, ammonia, and amine salts.
Claim 2
Independent Claim
118 words
A method for treating virus diseases, which comprises administering to a patient in need of said treatment an effective antiviral amount of a phosphonylmethoxyalkyladenine of the formula (I) ##STR3## wherein R 1 is methylene, --CH(OH)--CH 2 -- or ##STR4## and R 2 is a hydroxyl group, and, wherein, when R 1 is different from methylene, R 1 and R 2 may be linked with each other to form a cyclic ester group, said adenine derivative being in (RS) or (S) form when R 1 is different from methylene and further being in the form of a free acid or a salt thereof wherein the salts are selected from the group consisting of alkali metal, ammonia, and amine salts.
Claim 3
Dependent Claim
10 words
The method of claim 1, wherein said compound is (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.
Claim 4
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by a herpes virus.
Claim 5
Dependent Claim
14 words
A method of claim 1, wherein said virus disease is caused by pox virus.
Claim 6
Dependent Claim
14 words
The method of claim 1, wherein said virus disease is caused by a retrovirus.
Claim 7
Dependent Claim
13 words
The method of claim 1, wherein said virus disease is caused by reovirus.
Claim 8
Dependent Claim
14 words
The method of claim 1, wherein said virus disease is caused by parainfluenza virus.
Claim 9
Dependent Claim
14 words
The method of claim 1, wherein said virus disease is caused by sindbis virus.
Claim 10
Dependent Claim
14 words
The method of claim 1, wherein said virus disease is caused by polio virus.
Claim 11
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by vesicular stomatitis virus.
Claim 12
Dependent Claim
13 words
The method of claim 1, wherein said virus disease is caused by vaccinia.
Claim 13
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by moloney sarcoma virus.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-08 | 1991-08-10 | 1992-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-08 | 1995-08-10 | 1996-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-08 | 1999-08-10 | 2000-02-09 | $7700.00 | Window Closed / Lapsed |