US4605658A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antivirally active adenine derivatives
Assignee: Stichting Rega VZW
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Filing: 1984-10-05
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Granted: 1986-08-12
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Expires: 2004-10-05
Abstract
Abstract Certain esters of 3-(adenin-9-yl)-2-hydroxypropanoic acid are disclosed which exhibit an improved broad spectrum antiviral activity while having a low toxicity for living cells. They can be used for treatment of virus diseases in human and veterinary practice.
Inventors
- 👤 Antonin Holy
- 👤 Erik De Clercq
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 22:17
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/26; C07D473/32; C07D473/34
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
55 words
A method for treating virus diseases which comprises administering to a patient in need of said treatment an effective antiviral amount of a 3-(adenin-9-yl)-2-hydroxypropanoic acid ester of the formula (I): ##STR3## wherein R is linear or branched alkyl with the exception of tert-butyl and n-pentyl, n-octyl, methoxyethyl, or cyclohexyl, in (R), (S), or (RS) form.
Claim 2
Independent Claim
55 words
A method for treating virus diseases which comprises administering to a patient in need of said treatment an effective antiviral amount of a 3-(adenin-9-yl)-2-hydroxypropanoic acid ester of the formula (I): ##STR3## wherein R is linear or branched alkyl with the exception of tert-butyl and n-pentyl, n-octyl, methoxyethyl, or cyclohexyl, in (R), (S), or (RS) form.
Claim 3
Dependent Claim
9 words
The method of claim 1, wherein R is methyl.
Claim 4
Dependent Claim
9 words
The method of claim 1, wherein R is ethyl.
Claim 5
Dependent Claim
9 words
The method of claim 1, wherein R is 1-propyl.
Claim 6
Dependent Claim
9 words
The method of claim 1, wherein R is 2-propyl.
Claim 7
Dependent Claim
9 words
The method of claim 1, wherein R is 1-butyl.
Claim 8
Dependent Claim
9 words
The method of claim 1, wherein R is 2-butyl.
Claim 9
Dependent Claim
9 words
The method of claim 1, wherein R is 2-methylpropyl.
Claim 10
Dependent Claim
9 words
The method of claim 1, wherein R is 3-methylbutyl.
Claim 11
Dependent Claim
9 words
The method of claim 1, wherein R is 1-octyl.
Claim 12
Dependent Claim
9 words
The method of claim 1, wherein R is 2-methoxyethyl.
Claim 13
Dependent Claim
9 words
The method of claim 1 wherein R is cyclohexyl.
Claim 14
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by an RNA virus.
Claim 15
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by a DNA virus.
Claim 16
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by vesicular stomatitis virus.
Claim 17
Dependent Claim
14 words
The method of claim 1, wherein said virus disease is caued by vaccinia virus.
Claim 18
Dependent Claim
14 words
The method of claim 1, wherein said virus disease is caused by measles virus.
Claim 19
Dependent Claim
15 words
The method of claim 1, wherein said virus disease is caused by reovirus type 1.
Claim 20
Dependent Claim
38 words
The method of claim 1, wherein the ester of the formula (I) is administered in the form of a therapeutic composition comprising an effective antiviral amount of the ester of the formula (I) and a pharmaceutically acceptable excipient.
Claim 21
Dependent Claim
32 words
The method of claim 1, wherein the ester of the formula (I) is administered in a dose in an amount of between 0.1 mg and 1000 mg per kg of body weight.
References Cited (Backward Citations)
US4230708A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-11 | 1990-02-10 | 1990-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-11 | 1994-02-10 | 1994-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-11 | 1998-02-10 | 1998-08-12 | $7700.00 | Window Closed / Lapsed |