US4722865A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Poly(meth)acrylic network coated biologically or chemically active substrate and method of making same
Assignee: NEDERLANDSE CENTRALE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJKONDERZOEK A CORP OF NETHERLANDS
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Filing: 1985-04-24
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Granted: 1988-02-02
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Expires: 2005-04-24
Abstract
Abstract A solid substrate, which contains or consists of a biologically or chemically active substance, is coated with coating material containing at least one polymerizable crosslinkable polyfunctional acrylic or methacrylic compound whereafter the coating material is subjected to polymerization substantially in the absence of non-polymerizable components to form a network coating of polymer on the surface of the solid substrate. This coating permits either the controlled release of active substance from the coated substrate or the controlled access of material reacting with said active substance into the coated substrate and the controlled release of the resulting reaction products from the coated substrate.
Inventors
- 👤 Leendert Huizer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:54
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/284; A61K9/2846; C; C05; C05G; C05G5/00; C05G5/30; C05G5/37; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
97 words
A coated material comprising a solid substrate comprising a biologically or chemically active substance, and a permeable network coating comprising a water insoluble acrylate or methacrylate polymer formed by polymerization of a coating material comprising at least one crosslinkable polyfunctional acrylate or methacrylate compound and consisting essentially of components that are polymerized to form the network coating, said network coating being formed on at least a part of the surface of the solid substrate in a manner which substantially avoids agglomeration of the solid substrate wherein release of the active substance through the network coating is controlled.
Claim 2
Dependent Claim
97 words
A coated material comprising a solid substrate comprising a biologically or chemically active substance, and a permeable network coating comprising a water insoluble acrylate or methacrylate polymer formed by polymerization of a coating material comprising at least one crosslinkable polyfunctional acrylate or methacrylate compound and consisting essentially of components that are polymerized to form the network coating, said network coating being formed on at least a part of the surface of the solid substrate in a manner which substantially avoids agglomeration of the solid substrate wherein release of the active substance through the network coating is controlled.
Claim 3
Dependent Claim
39 words
A coated material according to claim 1, wherein the polyfunctional compound has the general formula ##STR1## wherein R 1 is H or CH 3 , n is 2, 3, or 4, and R is a polyalcohol or a polyamine.
Claim 4
Dependent Claim
31 words
A coated material according to claim 1, wherein the coating material is a liquid mixture comprising one or more high viscosity polymerizable compounds and one or more low viscosity polymerizable compounds.
Claim 5
Dependent Claim
26 words
A coated material according to claim 3, wherein the high viscosity polymerizable compounds are selected from the group consisting of urethane-(meth)acrylates, epoxy-(meth)acrylates, polyester-(meth)acrylates, polyether-(meth)acrylates and amine-(meth)acrylates.
Claim 6
Dependent Claim
24 words
A coated material according to claim 3, wherein the low viscosity polymerizable compounds are selected from the group consisting of triisopropyleneglycoldiacrylate, 1,6-n-hexanedioldiacrylate and trismethylolpropanetriacrylate.
Claim 7
Dependent Claim
17 words
A coated material according to claim 1 having an induction period of from 1 to 9 hours.
Claim 8
Dependent Claim
21 words
A coated material according to claim 1, wherein the coating material further comprises one or more monofunctional polymerizable monomers as modifiers.
Claim 9
Dependent Claim
15 words
A coated material according to claim 7, wherein the monofunctional polymerizable monomer is N-vinyl pyrollidone.
Claim 10
Independent Claim
87 words
A method for preparing coated materials having controlled release properties comprising (a) applying a coating material comprising at least one polymerizable, crosslinkable, polyfunctional acrylate or methacrylate compound to at least a part of the surface of a solid substrate in a manner which substantially avoids agglomeration of the solid substrate, said substrate comprising a biologically or chemically active substance; and (b) polymerizing the coating material to form a permeable network coating, wherein the coating material consists essentially of components that are polymerized to form the network coating.
Claim 11
Independent Claim
87 words
A method for preparing coated materials having controlled release properties comprising (a) applying a coating material comprising at least one polymerizable, crosslinkable, polyfunctional acrylate or methacrylate compound to at least a part of the surface of a solid substrate in a manner which substantially avoids agglomeration of the solid substrate, said substrate comprising a biologically or chemically active substance; and (b) polymerizing the coating material to form a permeable network coating, wherein the coating material consists essentially of components that are polymerized to form the network coating.
Claim 12
Dependent Claim
38 words
A method according to claim 9, wherein the polyfunctional compound has the general formula ##STR2## wherein R 1 is H or CH 3 , n is 2, 3, or 4, and R is a polyalcohol or a polyamine.
Claim 13
Dependent Claim
27 words
A method according to claim 9, wherein the coating material comprises one or more compounds selected from the group consisting of urethane-(meth)acrylates, epoxy-(meth)acrylates, polyester-(meth)acrylates, polyether-(meth)acrylates, and amine-(meth)acrylates.
Claim 14
Dependent Claim
20 words
A method according to claim 11, wherein the coating material further comprises one or more monofunctional polymerizable monomers as modifiers.
Claim 15
Dependent Claim
13 words
A method according to claim 12, wherein the monofunctional polymerizable monomer is N-vinylpyrrollidone.
Claim 16
Dependent Claim
29 words
A method according to claim 9, wherein the coating material is formed by mixing one or more high viscosity polymerizable compounds with one or more low viscosity polymerizable compounds.
Claim 17
Dependent Claim
15 words
A method according to claim 9, wherein radiation is used to polymerize the coating material.
Claim 18
Dependent Claim
18 words
A method according to claim 15, wherein the radiation is an electron beam, gamma radiation, or ultraviolet light.
Claim 19
Dependent Claim
13 words
A method according to claim 9, wherein the substrate is a particulate solid.
Claim 20
Dependent Claim
24 words
A method according to claim 17, wherein the coating material is applied to the particulate substrate while said substrate is in a fluidized state.
Claim 21
Dependent Claim
26 words
A method according to claim 9, wherein the active substance is selected from the group consisting of drugs, flavorants, fragrances, agrochemicals, fertilizers, catalysts, enzymes and microorganisms.
Claim 22
Dependent Claim
14 words
A coated material according to claim 1, wherein the substrate is a particulate solid.
Claim 23
Dependent Claim
25 words
A coated material according to claim 20, wherein the coating material is applied to the particulate substrate while said substrate is in a fluidized state.
Claim 24
Dependent Claim
27 words
A coated material according to claim 1, wherein the active substance is selected from the group consisting of drugs, flavorants, fragrances, agrochemicals, fertilizers, catalysts, enzymes and microorganisms.
References Cited (Backward Citations)
DE1248687B
Cited
DE1250456B
Cited
GB750809A
Cited
DE1254162B
Cited
DE1257801B
Cited
DE1270579B
Cited
DE1242573B
Cited
US3386851A
Cited
DE1592655B1
Cited
GB1269018A
Cited
US3661620A
Cited
US3857932A
Cited
US3694253A
Cited
US3967006A
Cited
US3904745A
Cited
US4007258A
Cited
US4178361A
Cited
FR2253553A1
Cited
SU543250A1
Cited
US4411754A
Cited
GB2017113A
Cited
US4321117A
Cited
US4180598A
Cited
US4209371A
Cited
US4379038A
Cited
US4359483A
Cited
US4490436A
Cited
US4572833A
Cited
US4574080A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-01 | 1991-08-03 | 1992-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-01 | 1995-08-03 | 1996-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-01 | 1999-08-03 | 2000-02-02 | $7700.00 | Window Closed / Lapsed |